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H2-Q7 Gene Detail
Summary
  • Symbol
    H2-Q7
  • Name
    histocompatibility 2, Q region locus 7
  • Synonyms
    H-2Q7, Ped, Qa-7, Qa7
  • Feature Type
    protein coding gene
  • IDs
    MGI:95936
    NCBI Gene: 15018
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr17:35658131-35662749 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.67 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • Strain Annotations
    9
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95936
 protein coding gene Chr17:35658131-35662749 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0023512
 protein coding gene Chr17:32758712-32762443 (-)
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0021435
 protein coding gene Chr17:30332109-30336155 (-)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0023381
 protein coding gene Chr17:32135238-32144431 (-)
FVB/NJ MGP_FVBNJ_G0023470
 protein coding gene Chr17:34273612-34275320 (-)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0023491
 protein coding gene Chr17:38133456-38137319 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031263
 protein coding gene Chr6:56211362-56216265 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0022425
 protein coding gene Chr17:33000838-33004872 (+)
WSB/EiJ MGP_WSBEiJ_G0022922
 protein coding gene Chr17:35183627-35184634 (+)



Homology
more
  • Human Ortholog
    HLA-A, major histocompatibility complex, class I, A
  • Vertebrate Orthologs
    18
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLA-A, major histocompatibility complex, class I, A
  • Synonyms
    HLAA
  • Links
    NCBI Gene ID: 3105
    neXtProt AC: NX_P04439
    UniProt: P04439

  • Chr Location
    6p22.1; chr6:29941260-29949572 (+)  GRCh38
  • Human Ortholog
    HLA-B, major histocompatibility complex, class I, B
  • Synonyms
    AS, B-4901, HLAB
  • Links
    NCBI Gene ID: 3106
    neXtProt AC: NX_P01889
    UniProt: P01889

  • Chr Location
    6p21.33; chr6:31353872-31367067 (-)  GRCh38
  • Human Ortholog
    HLA-C, major histocompatibility complex, class I, C
  • Synonyms
    D6S204, HLAC, HLA-JY3, HLC-C, MHC, PSORS1
  • Links
    NCBI Gene ID: 3107
    neXtProt AC: NX_P10321
    UniProt: P10321

  • Chr Location
    6p21.33; chr6:31268749-31272130 (-)  GRCh38
  • Human Ortholog
    HLA-E, major histocompatibility complex, class I, E
  • Synonyms
    HLA-6.2, QA1
  • Links
    NCBI Gene ID: 3133
    neXtProt AC: NX_P13747
    UniProt: P13747

  • Chr Location
    6p22.1; chr6:30489509-30494194 (+)  GRCh38
  • Human Ortholog
    HLA-F, major histocompatibility complex, class I, F
  • Synonyms
    CDA12, HLA-5.4, HLA-CDA12, HLAF
  • Links
    NCBI Gene ID: 3134
    neXtProt AC: NX_P30511
    UniProt: P30511

  • Chr Location
    6p22.1; chr6:29722775-29738532 (+)  GRCh38
  • Human Ortholog
    HLA-G, major histocompatibility complex, class I, G
  • Synonyms
    MHC-G
  • Links
    NCBI Gene ID: 3135
    neXtProt AC: NX_P17693
    UniProt: P17693

  • Chr Location
    6p22.1; chr6:29826474-29831125 (+)  GRCh38
Human Diseases
more
  • Diseases
    45 with human HLA-A,HLA-B,HLA-C,HLA-E,HLA-G associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype reference
This locus controls a widely distributed lymphocyte antigen recognized by monoclonal antibody, serology or CTL assay. Using all assays, antigen is present (allele a) in C57BL/6, DBA/1, DBA/2 and SWR and absent (allele b) in AKR, C3H and BALB/c. Other strain allele typings were assay-dependent.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    71
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    758
  • Tissues
    27
  • cDNA Data
    3
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15018 NCBI Gene Model | MGI Sequence Detail 4619 C57BL/6J ±  kb
transcript NM_010394 RefSeq | MGI Sequence Detail 1536 ZRU/MplStud  
polypeptide P14429 UniProt | EBI | MGI Sequence Detail 334 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000008410 H-2 class I histocompatibility antigen, Q7 alpha chain
    (term hierarchy)
  • PDB
    1K8D
  • InterPro Domains
    IPR050208 Antigen-presenting and immune regulatory MHC class I-related
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
    IPR011161 MHC class I-like antigen recognition-like
    IPR037055 MHC class I-like antigen recognition-like superfamily
  • GlyGen
    P14429 2 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
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  • All nucleic 30
    Genomic 19
    cDNA 3
    Primer pair 2
    Other 6

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-10419, MGD-MRK-10532, MGD-MRK-13227, MGD-MRK-13710, MGD-MRK-13715, MGD-MRK-13726
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 1
  • Earliest
    J:11962 Steinmetz M, et al., A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains. Cell. 1981 Sep;25(3):683-92
  • Latest
    J:190754 Ermakova O, et al., Construction and phenotypic analysis of mice carrying a duplication of the major histocompatibility class I (MHC-I) locus. Mamm Genome. 2012 Aug;23(7-8):443-53
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory