H2-T23 MGI Mouse Gene Detail - MGI:95957 - histocompatibility 2, T region locus 23

Symbol

H2-T23
Name

histocompatibility 2, T region locus 23
Synonyms

37b, 37c, H-2T23, Qa-1, Qa1, Qed-1, T18c, T18c(37), T23b, T23d

Feature Type

protein coding gene
IDs

MGI:95957
NCBI Gene: 15040
Alliance

gene page
Transcription Start Sites

5 TSS
Candidate for QTL

1 QTL

Sequence Map

Chr17:36340869-36343593 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.86 cM
Mapping Data

3 experiments

SNPs within 2kb

6 from dbSNP Build 142
Strain Annotations

17
RFLP

5

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95957	protein coding gene	Chr17:36340665-36343747 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023667	protein coding gene	Chr17:36253846-36258100 (-)
A/J	MGP_AJ_G0023622	protein coding gene	Chr17:35159062-35161738 (-)
AKR/J	MGP_AKRJ_G0023592	protein coding gene	Chr17:35556928-35563213 (-)
BALB/cJ	MGP_BALBcJ_G0023627	protein coding gene	Chr17:35273521-35378865 (-)
C3H/HeJ	MGP_C3HHeJ_G0023393	protein coding gene	Chr17:36013867-36021814 (-)
C57BL/6NJ	no annotation
CAROLI/EiJ	MGP_CAROLIEiJ_G0021429	protein coding gene	Chr17:30244884-30247704 (-)
CAST/EiJ	MGP_CASTEiJ_G0022884	protein coding gene	Chr17:36132162-36134723 (-)
CBA/J	MGP_CBAJ_G0023371	protein coding gene	Chr17:39310825-39323975 (-)
DBA/2J	MGP_DBA2J_G0023495	protein coding gene	Chr17:34480104-34510253 (-)
FVB/NJ	MGP_FVBNJ_G0023466	protein coding gene	Chr17:34230731-34231702 (-)
LP/J	MGP_LPJ_G0023575	protein coding gene	Chr17:36620526-36623717 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023487	protein coding gene	Chr17:38083352-38088894 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024116	protein coding gene	Chr17:35946641-35949484 (-)
PWK/PhJ	MGP_PWKPhJ_G0022635	protein coding gene	Chr17:33276576-33277696 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022454	protein coding gene	Chr17:33909422-33926524 (-)
WSB/EiJ	MGP_WSBEiJ_G0022950	protein coding gene	Chr17:36012551-36017087 (-)

Human Ortholog

HLA-E, major histocompatibility complex, class I, E

Vertebrate Orthologs

9

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HLA-E, major histocompatibility complex, class I, E
Synonyms

HLA-6.2, QA1
Links

HGNC:4962

NCBI Gene ID: 3133

neXtProt AC: NX_P13747

UniProt: P13747
Chr Location

6p22.1; chr6:30489509-30494194 (+) GRCh38

MGI Vertebrate Homology

H2-T23 stringent orthology
1 human;1 mouse;1 rat;7 zebrafish
HCOP

vertebrate homology predictions: HLA-E
Gene Tree

H2-T23

Diseases

45 with human HLA-A,HLA-B,HLA-C,HLA-E,HLA-G associations

				Human Disease	Mouse Models
				acquired immunodeficiency syndrome IDs acquired immunodeficiency syndrome DOID:635 EFO:0000765 ICD10CM:B20 MESH:D000163 NCI:C2851 UMLS_CUI:C0001175
				acute retinal necrosis syndrome IDs acute retinal necrosis syndrome DOID:3611 MESH:D015882 UMLS_CUI:C0035319
				allergic asthma IDs allergic asthma DOID:9415 DOID:9416 DOID:9417 ICD10CM:J45 ICD9CM:493.0 UMLS_CUI:C0155877
				alopecia IDs alopecia DOID:987 ICD10CM:L65.9 ICD9CM:704.0 ICD9CM:704.00 MESH:D000505 NCI:C50575 OMIM:PS203655 UMLS_CUI:C0002170
				ankylosing spondylitis IDs ankylosing spondylitis DOID:7147 EFO:0003898 ICD10CM:M45 ICD9CM:720.0 MESH:D013167 NCI:C84564 OMIM:PS106300 ORDO:825 UMLS_CUI:C0038013
				anterior uveitis IDs anterior uveitis DOID:1407 MESH:D014606 NCI:C35109 UMLS_CUI:C0042165
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				Behcet's disease IDs Behcet's disease DOID:13241 EFO:0003780 ICD10CM:M35.2 ICD9CM:136.1 ICD9CM_2006:136.1 MESH:D001528 NCI:C34416 OMIM:109650 UMLS_CUI:C0004943
				birdshot chorioretinopathy IDs birdshot chorioretinopathy DOID:0111079 MESH:D000080365 OMIM:605808 ORDO:179 UMLS_CUI:C1853959
				central nervous system vasculitis IDs central nervous system vasculitis DOID:525 MESH:D020293 NCI:C84622 UMLS_CUI:C0751878
				cerebral infarction IDs cerebral infarction DOID:3526 ICD10CM:I63 MESH:D002544 NCI:C50486 OMIM:601367 UMLS_CUI:C0007785
				cervical cancer IDs cervical cancer DOID:4362 DOID:4361 ICD10CM:C53 ICD9CM:180 ICD9CM:180.9 MESH:D002583 NCI:C2940 NCI:C9311 OMIM:603956 UMLS_CUI:C0007847 UMLS_CUI:C0007873
				colitis IDs colitis DOID:0060180 EFO:0003872 ICD10CM:K52.9 MESH:D003092 NCI:C26723 UMLS_CUI:C0009319
				COVID-19 IDs COVID-19 DOID:0080600 ICD10CM:U07.1 MESH:D000086382 NCI:C171133 UMLS_CUI:C5203670
				Cytomegalovirus retinitis IDs Cytomegalovirus retinitis DOID:0080160 MESH:D017726
				dermatitis IDs dermatitis DOID:2723 DOID:8614 DOID:8917 ICD10CM:L30.9 MESH:D003872 NCI:C2983 UMLS_CUI:C0011603
				diabetic retinopathy IDs diabetic retinopathy DOID:8947 ICD9CM:362.0 MESH:D003930 NCI:C34538 UMLS_CUI:C0011884
				erythema nodosum IDs erythema nodosum DOID:0080750 MESH:D004893
				Graves' disease IDs Graves' disease DOID:12361 EFO:0004237 ICD10CM:E05.0 MESH:D006111 NCI:C3071 OMIM:275000 UMLS_CUI:C0018213
				hepatitis C IDs hepatitis C DOID:1883 DOID:12430 DOID:12432 DOID:2049 EFO:0003047 ICD10CM:B19.20 ICD9CM:070.7 MESH:D006526 NCI:C3098 UMLS_CUI:C0019196
				human immunodeficiency virus infectious disease IDs human immunodeficiency virus infectious disease DOID:526 ICD10CM:B20 ICD9CM:042 ICD9CM:042-042.99 MESH:D015658 NCI:C3108 UMLS_CUI:C0019693
				Meniere's disease IDs Meniere's disease DOID:9849 ICD10CM:H81.0 ICD9CM:386.0 ICD9CM:386.00 MESH:D008575 NCI:C185243 OMIM:156000 UMLS_CUI:C0025281
				mitral valve prolapse IDs mitral valve prolapse DOID:988 MESH:D008945 NCI:C50655 OMIM:157700 OMIM:607829 OMIM:610840 UMLS_CUI:C0026267
				Moyamoya disease IDs Moyamoya disease DOID:13099 ICD10CM:I67.5 ICD9CM:437.5 MESH:D009072 NCI:C84895 OMIM:252350 OMIM:300845 OMIM:607151 OMIM:608796 OMIM:614042 OMIM:615750 ORDO:2573 ORDO:280679 ORDO:401945 UMLS_CUI:C0026654
				occupational asthma IDs occupational asthma DOID:0080820
				otosclerosis IDs otosclerosis DOID:12185 EFO:0004213 ICD10CM:H80.80 ICD9CM:387.8 OMIM:PS166800 ORDO:2794 UMLS_CUI:C0029696
				pre-eclampsia IDs pre-eclampsia DOID:10591 DOID:12684 ICD10CM:O14 MESH:D011225 NCI:C85021 OMIM:189800 OMIM:609402 OMIM:609403 OMIM:609404 OMIM:614592 ORDO:275555 UMLS_CUI:C0032914
				psoriasis 1 IDs psoriasis 1 DOID:0111286 OMIM:177900
				reactive arthritis IDs reactive arthritis DOID:6196 DOID:10148 DOID:11891 DOID:13318 DOID:13519 DOID:13782 DOID:13783 DOID:13784 DOID:13785 DOID:6194 DOID:9760 ICD10CM:M02.10 ICD10CM:M02.3 ICD9CM:099.3 ICD9CM:711.3 ICD9CM:711.30 MESH:D016918 NCI:C34975 UMLS_CUI:C0035012 UMLS_CUI:C0152085
				retinal vasculitis IDs retinal vasculitis DOID:11563 ICD10CM:H35.06 ICD9CM:362.18 MESH:D031300 UMLS_CUI:C0152026
				retinopathy of prematurity IDs retinopathy of prematurity DOID:13025 ICD10CM:H35.1 ICD9CM_2006:362.21 ICD9CM:362.20 ICD9CM:362.21 MESH:D012178 NCI:C34982 UMLS_CUI:C0035344
				sarcoidosis IDs sarcoidosis DOID:11335 ICD10CM:D86 ICD9CM:135 MESH:D012507 NCI:C34995 ORDO:797 UMLS_CUI:C0036202
				scleroderma IDs scleroderma DOID:419 MESH:D012594 NCI:C26746 UMLS_CUI:C0011644
				sensorineural hearing loss IDs sensorineural hearing loss DOID:10003 DOID:11053 DOID:12112 DOID:12114 ICD10CM:H90.5 ICD9CM_2006:389.11 ICD9CM_2006:389.14 ICD9CM:389.1 ICD9CM:389.10 ICD9CM:389.14 MESH:D006319 NCI:C26739 UMLS_CUI:C0018784
				severe acute respiratory syndrome IDs severe acute respiratory syndrome DOID:2945 ICD10CM:J12.81 ICD9CM:079.82 MESH:D045169 NCI:C85064 UMLS_CUI:C1175175
				spondyloarthropathy IDs spondyloarthropathy DOID:1123 MESH:D025242 UMLS_CUI:C0949691
				Stevens-Johnson syndrome IDs Stevens-Johnson syndrome DOID:0050426 EFO:0004276 ICD10CM:L51.1 ICD9CM:695.13 ICD9CM:695.15 MESH:D013262 NCI:C79484 UMLS_CUI:C0038325
				synovitis IDs synovitis DOID:2703 MESH:D013585 NCI:C50766 UMLS_CUI:C0039103
				Takayasu's arteritis IDs Takayasu's arteritis DOID:2508 DOID:13377 ICD10CM:M31.4 ICD9CM:446.7 MESH:D001015 MESH:D013625 NCI:C34391 NCI:C35062 OMIM:207600 UMLS_CUI:C0003490 UMLS_CUI:C0039263
				thromboangiitis obliterans IDs thromboangiitis obliterans DOID:12918 ICD10CM:I73.1 ICD9CM:443.1 MESH:D013919 NCI:C35070 OMIM:211480 UMLS_CUI:C0040021
				thrombophlebitis IDs thrombophlebitis DOID:3875 DOID:1146 ICD10CM:I80.0 ICD9CM_2006:451.0 ICD9CM:451.0 MESH:D013924 NCI:C3410 UMLS_CUI:C0040046 UMLS_CUI:C0265057
				trachoma IDs trachoma DOID:11265 DOID:13013 DOID:13264 ICD10CM:A71 ICD10CM:A71.0 ICD10CM:A71.1 ICD9CM:076 ICD9CM:076.0 ICD9CM:076.1 ICD9CM:076.9 MESH:D014141 UMLS_CUI:C0040592 UMLS_CUI:C0153107 UMLS_CUI:C0153108
				tuberculosis IDs tuberculosis DOID:399 DOID:10096 DOID:12688 DOID:12691 DOID:415 DOID:9901 DOID:9902 MESH:D014375 UMLS_CUI:C0041295
				uveitis IDs uveitis DOID:13141 ICD10CM:H20.9 MESH:D014605 NCI:C26909 UMLS_CUI:C0042164
				vulva cancer IDs vulva cancer DOID:1245 DOID:1282 ICD10CM:C51 ICD9CM:184.4 MESH:D014846 NCI:C3443 NCI:C7502 UMLS_CUI:C0042995 UMLS_CUI:C0375071

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

3
Targeted

6
Genomic Mutations

2 involving H2-T23
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available

CD4⁺ T cells from mice with a homozygous null mutation have enhanced responses after infection or immunization, are resistant to suppressor activity mediated by a subset of CD8⁺ T cells, but are more susceptible to NK cell lysis.

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All GO Annotations

50
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

731
Tissues

21
cDNA Data

10
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

58
RefSeq

2
UniProt

14
CCDS

CCDS28715.1

Ensembl

ENSMUSG00000067212 (Evidence)
NCBI Gene

15040

			Length	Strain/Species	Flank
genomic	15040	NCBI Gene Model \| MGI Sequence Detail	2725	C57BL/6J	± kb
transcript	NM_010398	RefSeq \| MGI Sequence Detail	1317	ZRU/MplStud
polypeptide	P06339	UniProt \| EBI \| MGI Sequence Detail	357	Not Applicable

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UniProt

14 Sequences
Protein Ontology

PR:000008412 H-2 class I histocompatibility antigen, D-37 alpha chain

(term hierarchy)
PDB

3VJ6, 5VCL, 8UMO
InterPro Domains

IPR050208 Antigen-presenting and immune regulatory MHC class I-related

IPR003597 Immunoglobulin C1-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003006 Immunoglobulin/major histocompatibility complex, conserved site

IPR011162 MHC classes I/II-like antigen recognition protein

IPR001039 MHC class I alpha chain, alpha1 alpha2 domains

IPR011161 MHC class I-like antigen recognition-like

IPR037055 MHC class I-like antigen recognition-like superfamily
GlyGen

P06339 2 sites, 1 N-linked glycan (1 site)

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All nucleic 16

Genomic 3

cDNA 12

Primer pair 1

Microarray probesets 4

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MGD-MRK-10439, MGD-MRK-10553

Summaries

All 93

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 37
Earliest

J:12076 Stanton TH, et al., A new serologically defined locus, Qa-1, in the Tla-region of the mouse. Immunogenetics. 1976;3:525-531
Latest

J:346013 Kim HJ, et al., A narrow T cell receptor repertoire instructs thymic differentiation of MHC class Ib-restricted CD8+ regulatory T cells. J Clin Invest. 2024 Jan 2;134(1)

TSS for H2-T23:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr147949	Chr17:36343574-36343634 (-)	-11 bp
Tssr5112	Chr17:36343560-36343571 (-)	27 bp
Tssr147948	Chr17:36343455-36343467 (-)	132 bp
Tssr147947	Chr17:36343408-36343454 (-)	162 bp
Tssr147946	Chr17:36341512-36341545 (-)	2,064 bp

H2-T23 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Cia1	Chr17, syntenic		J:81372	Microarray gene expression analysis was used to identify candidate genes for QTLs associated with collagen-induced arthritis. RNA from inflamed paws of collagen-treated mice were used in the microarray analysis and compared to RNA from normal paws. 223 genes showed a four-fold or greater expression difference between inflamed and normal paws. Nine of these genes are located near previously identified arthritis severity/susceptibility QTLs and may be considered for candidates. For Cia1 on mouse Chromosome 17 (18.6 cM near the H2 locus) differential expression was observed for H2-Eb1 (18.66 cM) and H2-T23 (19.73 cM). For Cia2 and Cia4 on mouse Chromosome 2 (both are located at 34 cM) differential expression was observed for Fap (36 cM) and Gcg (36 cM). For Cia3 (48.7 cM) and Cia6 (30 cM) on mouse Chromosome 6 differential expression was observed for Raf1 (52.5 cM) and Slc6a6 (38.2 cM), respectively. For Cia5 (40 cM) on mouse Chromosome 4 differential expression was observed for Ctsk (47.9 cM) and Cd53(50.5 cM). For Cia8 (40.4 cM) on mouse Chromosome 10 differential expression was observed for Bsg (42.4 cM).

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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