Hck MGI Mouse Gene Detail - MGI:96052 - hemopoietic cell kinase

Symbol

Hck
Name

hemopoietic cell kinase
Synonyms

Bmk, Hck-1

Feature Type

protein coding gene
IDs

MGI:96052
NCBI Gene: 15162
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr2:152950388-152993361 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 75.41 cM
Mapping Data

15 experiments

SNPs within 2kb

1285 from dbSNP Build 142
Strain Annotations

18
RFLP

6

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96052	protein coding gene	Chr2:152950388-152993361 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026687	protein coding gene	Chr2:157715277-157763858 (+)
A/J	MGP_AJ_G0026653	protein coding gene	Chr2:151410238-151453165 (+)
AKR/J	MGP_AKRJ_G0026623	protein coding gene	Chr2:155834527-155878091 (+)
BALB/cJ	MGP_BALBcJ_G0026662	protein coding gene	Chr2:151720249-151763362 (+)
C3H/HeJ	MGP_C3HHeJ_G0026405	protein coding gene	Chr2:156204483-156248853 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027111	protein coding gene	Chr2:162286174-162334961 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024482	protein coding gene	Chr2:144993794-145036415 (+)
CAST/EiJ	MGP_CASTEiJ_G0025866	protein coding gene	Chr2:156460828-156504648 (+)
CBA/J	MGP_CBAJ_G0026383	protein coding gene	Chr2:168258845-168317506 (+)
DBA/2J	MGP_DBA2J_G0026519	protein coding gene	Chr2:150619684-150662800 (+)
FVB/NJ	MGP_FVBNJ_G0026485	protein coding gene	Chr2:149081121-149124596 (+)
LP/J	MGP_LPJ_G0026623	protein coding gene	Chr2:157863008-157907836 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026506	protein coding gene	Chr2:172317445-172362646 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027167	protein coding gene	Chr2:155727264-155776248 (+)
PWK/PhJ	MGP_PWKPhJ_G0025600	protein coding gene	Chr2:150150485-150194685 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025403	protein coding gene	Chr2:154566027-154610477 (+)
WSB/EiJ	MGP_WSBEiJ_G0025936	protein coding gene	Chr2:156631985-156674994 (+)

Human Ortholog

HCK, HCK proto-oncogene, Src family tyrosine kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HCK, HCK proto-oncogene, Src family tyrosine kinase
Synonyms

AIPCV, JTK9, p59Hck, p61Hck
Links

HGNC:4840

NCBI Gene ID: 3055

neXtProt AC: NX_P08631

UniProt: P08631
Chr Location

20q11.21; chr20:32052197-32101856 (+) GRCh38

MGI Vertebrate Homology

Hck stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HCK
Gene Tree

Hck

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Phenotype Summary

23 phenotypes from 2 alleles in 3 genetic backgrounds
24 phenotypes from multigenic genotypes
69 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (ENU)

1
Endonuclease-mediated

5
Gene trapped

6
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Macrophages from mice homozygous for a targeted null mutation exhibit impaired phagocytosis.

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All GO Annotations

51
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

805
Tissues

38
cDNA Data

30
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hck

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All Sequences

46
RefSeq

4
UniProt

2
CCDS

CCDS38284.1, CCDS50756.1

Ensembl

ENSMUSG00000003283 (Evidence)
NCBI Gene

15162

			Length	Strain/Species	Flank
genomic	15162	NCBI Gene Model \| MGI Sequence Detail	42974	C57BL/6J	± kb
transcript	NM_010407	RefSeq \| MGI Sequence Detail	2107	ZRU/MplStud
polypeptide	P08103	UniProt \| EBI \| MGI Sequence Detail	524	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008473 tyrosine-protein kinase HCK

(term hierarchy)
EC

2.7.10.2
InterPro Domains

IPR050198 Non-receptor tyrosine kinases involved in cell signaling

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR035851 Tyrosine-protein kinase HCK, SH2 domain

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All nucleic 37

Genomic 2

cDNA 32

Primer pair 3

Microarray probesets 3

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MGD-MRK-10666, MGD-MRK-10667, MGD-MRK-1590, MGI:2139076

Summaries

All 135

Developmental Gene Expression 9

Gene Ontology 8

Phenotypes 69
Earliest

J:8946 Holtzman DA, et al., Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells. Proc Natl Acad Sci U S A. 1987 Dec;84(23):8325-9
Latest

J:338320 Chen M, et al., HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy. Nat Commun. 2023 Jul 18;14(1):4297

TSS for Hck:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20863	Chr2:152949576-152949593 (+)	-803 bp
Tssr20864	Chr2:152949622-152949629 (+)	-762 bp
Tssr20865	Chr2:152950394-152950404 (+)	11 bp
Tssr20866	Chr2:152950409-152950462 (+)	48 bp
Tssr20867	Chr2:152956396-152956426 (+)	6,023 bp
Tssr20868	Chr2:152959528-152959550 (+)	9,151 bp
Tssr20869	Chr2:152962283-152962318 (+)	11,913 bp
Tssr20870	Chr2:152967423-152967455 (+)	17,051 bp
Tssr20871	Chr2:152978485-152978488 (+)	28,099 bp
Tssr20872	Chr2:152989403-152989412 (+)	39,020 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24