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Mst1 Gene Detail
Summary
  • Symbol
    Mst1
  • Name
    macrophage stimulating 1 (hepatocyte growth factor-like)
  • Synonyms
    D3F15S2h, D9H3F15S2, DNF15S2h, Hgfl
  • Feature Type
    protein coding gene
  • IDs
    MGI:96080
    NCBI Gene: 15235
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107957635-107962202 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.07 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    135 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96080
 protein coding gene Chr9:107957607-107962226 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035285
 protein coding gene Chr9:110009501-110014068 (+)
A/J MGP_AJ_G0035264
 protein coding gene Chr9:105985918-105990485 (+)
AKR/J MGP_AKRJ_G0035196
 protein coding gene Chr9:108630739-108635307 (+)
BALB/cJ MGP_BALBcJ_G0035258
 protein coding gene Chr9:105682694-105687261 (+)
C3H/HeJ MGP_C3HHeJ_G0034968
 protein coding gene Chr9:109029205-109033772 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035778
 protein coding gene Chr9:112989426-112993993 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032676
 protein coding gene Chr9:103420595-103425206 (+)
CAST/EiJ MGP_CASTEiJ_G0034279
 protein coding gene Chr9:108985970-108990537 (+)
CBA/J MGP_CBAJ_G0034936
 protein coding gene Chr9:116979285-116983852 (+)
DBA/2J MGP_DBA2J_G0035097
 protein coding gene Chr9:105441260-105445909 (+)
FVB/NJ MGP_FVBNJ_G0035045
 protein coding gene Chr9:104210427-104214994 (+)
LP/J MGP_LPJ_G0035173
 protein coding gene Chr9:110197945-110202512 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035084
 protein coding gene Chr9:118574389-118578956 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035799
 protein coding gene Chr9:108913127-108917695 (+)
PWK/PhJ MGP_PWKPhJ_G0033986
 protein coding gene Chr9:105762685-105767300 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033821
 protein coding gene Chr9:108969467-108974043 (+)
WSB/EiJ MGP_WSBEiJ_G0034400
 protein coding gene Chr9:108788965-108793532 (+)



Homology
more
  • Human Ortholog
    MST1, macrophage stimulating 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MST1, macrophage stimulating 1
  • Synonyms
    D3F15S2, DNF15S2, HGFL, MSP, NF15S2
  • Links
    NCBI Gene ID: 4485
    neXtProt AC: NX_P26927
    UniProt: P26927

  • Chr Location
    3p21.31; chr3:49683947-49689501 (-)  GRCh38
  • Human Ortholog
    MST1L, macrophage stimulating 1 like (pseudogene)
  • Synonyms
    BRF-1, D1F15S1A, MSPL-7, MSPL7, MST1P, MST1P7, MST1P9, MSTP7, MSTP9
  • Links
    NCBI Gene ID: 11223
    neXtProt AC: NX_Q2TV78
    UniProt: Q2TV78

  • Chr Location
    1p36.13; chr1:16757120-16764480 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lipid-filled cytoplasmic vacuoles in hepatocytes throughout the liver lobules.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    789
  • Tissues
    35
  • cDNA Data
    21
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032591 Ensembl Gene Model | MGI Sequence Detail 4568 C57BL/6J ±  kb
    transcript ENSMUST00000035211 Ensembl | MGI Sequence Detail 2262 Not Applicable  
    polypeptide ENSMUSP00000035211 Ensembl | MGI Sequence Detail 716 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 3
      cDNA 21

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10705, MGD-MRK-6224, MGD-MRK-8535, MGD-MRK-8876
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:11449 Degen SJ, et al., Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development. Biochemistry. 1991 Oct 8;30(40):9781-91
    • Latest
      J:358815 Guo ZF, et al., Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice. JCI Insight. 2024 Sep 10;9(17)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory