Hmgn1 MGI Mouse Gene Detail - MGI:96120 - high mobility group nucleosomal binding domain 1

Symbol

Hmgn1
Name

high mobility group nucleosomal binding domain 1
Synonyms

Hmg14, HMG-14

Feature Type

protein coding gene
IDs

MGI:96120
NCBI Gene: 15312
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr16:95922788-95928925 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 56.83 cM
Mapping Data

8 experiments

SNPs within 2kb

47 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96120	protein coding gene	Chr16:95921818-95928929 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023080	protein coding gene	Chr16:97479718-97486868 (-)
A/J	MGP_AJ_G0023048	protein coding gene	Chr16:92858175-92865624 (-)
AKR/J	MGP_AKRJ_G0023018	protein coding gene	Chr16:95727371-95735313 (-)
BALB/cJ	MGP_BALBcJ_G0023050	protein coding gene	Chr16:93415831-93422324 (-)
C3H/HeJ	MGP_C3HHeJ_G0022811	protein coding gene	Chr16:96251349-96257366 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023497	protein coding gene	Chr16:100567456-100577962 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020999	protein coding gene	Chr16:90716785-90720530 (-)
CAST/EiJ	MGP_CASTEiJ_G0022330	protein coding gene	Chr16:97041386-97046762 (-)
CBA/J	MGP_CBAJ_G0022780	protein coding gene	Chr16:104908269-104916757 (-)
DBA/2J	MGP_DBA2J_G0022914	protein coding gene	Chr16:92742456-92749817 (-)
FVB/NJ	MGP_FVBNJ_G0022888	protein coding gene	Chr16:91920569-91926839 (-)
LP/J	MGP_LPJ_G0022984	protein coding gene	Chr16:97114104-97122623 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022909	protein coding gene	Chr16:109140329-109146817 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023515	protein coding gene	Chr16:96258041-96265325 (-)
PWK/PhJ	MGP_PWKPhJ_G0022075	protein coding gene	Chr16:93042753-93049968 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021905	protein coding gene	Chr16:95798451-95808298 (-)
WSB/EiJ	MGP_WSBEiJ_G0022381	protein coding gene	Chr16:96524857-96531386 (-)

Human Ortholog

HMGN1, high mobility group nucleosome binding domain 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HMGN1, high mobility group nucleosome binding domain 1
Synonyms

HMG14
Links

HGNC:4984

NCBI Gene ID: 3150

neXtProt AC: NX_P05114

UniProt: P05114
Chr Location

21q22.2; chr21:39342315-39349647 (-) GRCh38

MGI Vertebrate Homology

Hmgn1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HMGN1
Gene Tree

Hmgn1

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References

6 with disease annotations

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Phenotype Summary

22 phenotypes from 2 alleles in 3 genetic backgrounds
116 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

37
Endonuclease-mediated

4
Gene trapped

23
Spontaneous

1
Targeted

8
Genomic Mutations

7 involving Hmgn1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele display partial embryonic lethality, increased cellular sensitivity to ultraviolet- and gamma-irradiation, increased tumor incidence and metastatic potential, increased incidence of ionizing radiation-induced tumors, and abnormal cell cycle checkpoint function.

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All GO Annotations

22
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1113
Tissues

278
cDNA Data

14
Literature Summary

17

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hmgn1

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All Sequences

42
RefSeq

2
UniProt

3
CCDS

CCDS28353.1

Ensembl

ENSMUSG00000040681 (Evidence)
NCBI Gene

15312

			Length	Strain/Species	Flank
genomic	15312	NCBI Gene Model \| MGI Sequence Detail	6138	C57BL/6J	± kb
transcript	NM_008251	RefSeq \| MGI Sequence Detail	1200	Not Specified
polypeptide	P18608	UniProt \| EBI \| MGI Sequence Detail	96	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008639 non-histone chromosomal protein HMG-14

(term hierarchy)
InterPro Domains

IPR000079 High mobility group protein HMGN

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All nucleic 24

Genomic 3

cDNA 15

Primer pair 4

Other 2

Microarray probesets 6

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MGD-MRK-10756

Summaries

All 166

Developmental Gene Expression 17

Diseases 6

Gene Ontology 10

Phenotypes 116
Earliest

J:10494 Pash J, et al., Chromosomal protein HMG-14 gene maps to the Down syndrome region of human chromosome 21 and is overexpressed in mouse trisomy 16. Proc Natl Acad Sci U S A. 1990 May;87(10):3836-40
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hmgn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr142288	Chr16:95929216-95929231 (-)	-299 bp
Tssr142287	Chr16:95928889-95928936 (-)	12 bp
Tssr142286	Chr16:95928664-95928696 (-)	245 bp
Tssr142285	Chr16:95926158-95926167 (-)	2,762 bp
Tssr142284	Chr16:95926142-95926145 (-)	2,781 bp
Tssr142283	Chr16:95926116-95926125 (-)	2,804 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24