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Hmgb2 Gene Detail
Summary
  • Symbol
    Hmgb2
  • Name
    high mobility group box 2
  • Synonyms
    Hmg2, HMG-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96157
    NCBI Gene: 97165
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:57964941-57969033 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 29.90 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    174 from dbSNP Build 142
  • Strain Annotations
    15
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96157
protein coding gene Chr8:57964877-57969033 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033624
protein coding gene Chr8:57245538-57251447 (+)
A/J MGP_AJ_G0033606
protein coding gene Chr8:54828291-54832903 (+)
AKR/J MGP_AKRJ_G0033531
protein coding gene Chr8:56455680-56461258 (+)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0033312
protein coding gene Chr8:57111604-57117921 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034119
protein coding gene Chr8:59448728-59464460 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031067
protein coding gene Chr8:50379877-50384064 (+)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0033444
protein coding gene Chr8:54636676-54640433 (+)
FVB/NJ MGP_FVBNJ_G0033385
protein coding gene Chr8:53992963-53998679 (+)
LP/J MGP_LPJ_G0033532
protein coding gene Chr8:57254119-57257069 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033429
protein coding gene Chr8:63176688-63185217 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034137
protein coding gene Chr8:56694274-56699093 (+)
PWK/PhJ MGP_PWKPhJ_G0032346
protein coding gene Chr8:53948981-53953162 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032182
protein coding gene Chr8:55570127-55574819 (+)
WSB/EiJ MGP_WSBEiJ_G0032754
protein coding gene Chr8:56941412-56947079 (+)



Homology
more
  • Human Ortholog
    HMGB2, high mobility group box 2
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMGB2, high mobility group box 2
  • Synonyms
    HMG2
  • Links
    NCBI Gene ID: 3148
    neXtProt AC: NX_P26583
    UniProt: P26583

  • Chr Location
    4q34.1; chr4:173331376-173334432 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for disruptions in this gene display reduced fertility. Female fertility is normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054717 Ensembl Gene Model | MGI Sequence Detail 4093 C57BL/6J ±  kb
    transcript ENSMUST00000067925 Ensembl | MGI Sequence Detail 2628 Not Applicable  
    polypeptide ENSMUSP00000065940 Ensembl | MGI Sequence Detail 210 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000008631 high mobility group protein B2
    • InterPro Domains
      IPR009071 High mobility group box domain
      IPR036910 High mobility group box domain superfamily
      IPR050342 High Mobility Group Box (HMGB)
      IPR017967 HMG box A DNA-binding domain, conserved site
    • GlyGen
      P30681 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 27
      Primer pair 3
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-10793, MGI:2140686
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 24
      Gene Ontology 17
      Phenotypes 18
    • Earliest
      J:2642 Stolzenburg F, et al., Nucleotide sequence of a mouse cDNA encoding the non-histone chromosomal high mobility group protein-2 (HMG-2) [published erratum appears in Nucleic Acids Res 1992 Oct 11;20(19):5262]. Nucleic Acids Res. 1992 Sep 25;20(18):4927
    • Latest
      J:345311 Ferguson CA, et al., Identification and characterization of Hand2 upstream genomic enhancers active in developing stomach and limbs. Dev Dyn. 2024 Feb;253(2):215-232

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    12/10/2024
    MGI 6.24
    The Jackson Laboratory