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Hmga1 Gene Detail
Summary
  • Symbol
    Hmga1
  • Name
    high mobility group AT-hook 1
  • Synonyms
    Hmga1a, Hmga1b, Hmgi, Hmgiy, HMG-I(Y), HMGI(Y), HMGY
  • Feature Type
    protein coding gene
  • IDs
    MGI:96160
    NCBI Gene: 15361
  • Alliance
    gene page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:27775471-27782648 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 14.50 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    85 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96160
 protein coding gene Chr17:27774798-27782649 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023421
 protein coding gene Chr17:26869006-26874844 (+)
A/J MGP_AJ_G0023378
 protein coding gene Chr17:26015036-26025545 (+)
AKR/J MGP_AKRJ_G0023344
 protein coding gene Chr17:26180266-26186226 (+)
BALB/cJ MGP_BALBcJ_G0023383
 protein coding gene Chr17:26293562-26300641 (+)
C3H/HeJ MGP_C3HHeJ_G0023144
 protein coding gene Chr17:26550888-26559234 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023826
 protein coding gene Chr17:27981168-27992931 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021300
 protein coding gene Chr17:23403013-23410089 (+)
CAST/EiJ MGP_CASTEiJ_G0022645
 protein coding gene Chr17:26499533-26508176 (+)
CBA/J MGP_CBAJ_G0023118
 protein coding gene Chr17:28943256-28953791 (+)
DBA/2J MGP_DBA2J_G0023250
 protein coding gene Chr17:25580314-25588137 (+)
FVB/NJ MGP_FVBNJ_G0023219
 protein coding gene Chr17:25361789-25371376 (+)
LP/J MGP_LPJ_G0023327
 protein coding gene Chr17:27127835-27138350 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023237
 protein coding gene Chr17:28437784-28446861 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023867
 protein coding gene Chr17:26582147-26592266 (+)
PWK/PhJ MGP_PWKPhJ_G0022395
 protein coding gene Chr17:24363518-24370814 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022213
 protein coding gene Chr17:24584980-24593367 (+)
WSB/EiJ MGP_WSBEiJ_G0022708
 protein coding gene Chr17:26572458-26579655 (+)



Homology
more
  • Human Ortholog
    HMGA1, high mobility group AT-hook 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMGA1, high mobility group AT-hook 1
  • Synonyms
    HMGA1A, HMGIY, HMG-R
  • Links
    NCBI Gene ID: 3159
    neXtProt AC: NX_P17096
    UniProt: P17096

  • Chr Location
    6p21.31; chr6:34236873-34246231 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with Hmga1 mouse models; 1 with human HMGA1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 5 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Although haploinsufficiency at this locus is not compatible with germline transmission of one allele at this locus, mice homozygous for two other disruptions are fertile. Abnormalities are seen in glucose metabolism and in the cardiovascular system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    92
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1425
  • Tissues
    265
  • cDNA Data
    22
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046711 Ensembl Gene Model | MGI Sequence Detail 7178 C57BL/6J ±  kb
    transcript ENSMUST00000231866 Ensembl | MGI Sequence Detail 584 Not Applicable  
    polypeptide ENSMUSP00000155966 Ensembl | MGI Sequence Detail 118 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 25
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10796, MGI:2144347
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 27
      Diseases 3
      Gene Ontology 19
      Phenotypes 40
    • Earliest
      J:9471 Johnson KR, et al., Complete murine cDNA sequence, genomic structure, and tissue expression of the high mobility group protein HMG-I(Y). J Biol Chem. 1988 Dec 5;263(34):18338-42
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory