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Hoxa13 Gene Detail
Summary
  • Symbol
    Hoxa13
  • Name
    homeobox A13
  • Synonyms
    Hox-1.10
  • Feature Type
    protein coding gene
  • IDs
    MGI:96173
    NCBI Gene: 15398
  • Member of
    Hoxa cluster
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:52235833-52237865 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 25.41 cM
  • Mapping Data
    18 experiments
Strain
Comparison
more
  • SNPs within 2kb
    72 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96173
 protein coding gene Chr6:52234674-52237865 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030750
 protein coding gene Chr6:51501261-51506054 (-)
A/J MGP_AJ_G0030719
 protein coding gene Chr6:49093534-49096722 (-)
AKR/J MGP_AKRJ_G0030646
 protein coding gene Chr6:50799837-50803023 (-)
BALB/cJ MGP_BALBcJ_G0030731
 protein coding gene Chr6:49454865-49459099 (-)
C3H/HeJ MGP_C3HHeJ_G0030444
 protein coding gene Chr6:50811288-50814440 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031186
 protein coding gene Chr6:52638157-52641221 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028392
 protein coding gene Chr6:46741071-46744270 (-)
CAST/EiJ MGP_CASTEiJ_G0029847
 protein coding gene Chr6:50624713-50628429 (-)
CBA/J MGP_CBAJ_G0030418
 protein coding gene Chr6:54846560-54853019 (-)
DBA/2J MGP_DBA2J_G0030568
 protein coding gene Chr6:49016342-49019448 (-)
FVB/NJ MGP_FVBNJ_G0030520
 protein coding gene Chr6:48627399-48630506 (-)
LP/J MGP_LPJ_G0030653
 protein coding gene Chr6:51478482-51482256 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030554
 protein coding gene Chr6:57464971-57469892 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031216
 protein coding gene Chr6:50728873-50739880 (-)
PWK/PhJ MGP_PWKPhJ_G0029560
 protein coding gene Chr6:48640901-48644161 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029394
 protein coding gene Chr6:50065634-50070091 (-)
WSB/EiJ MGP_WSBEiJ_G0029924
 protein coding gene Chr6:50745617-50750344 (-)



Homology
more
  • Human Ortholog
    HOXA13, homeobox A13
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOXA13, homeobox A13
  • Synonyms
    HOX1, HOX1J
  • Links
    NCBI Gene ID: 3209
    neXtProt AC: NX_P31271
    UniProt: P31271

  • Chr Location
    7p15.2; chr7:27193503-27200091 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hoxa13 mouse models; 2 with human HOXA13 associations

Human Disease Mouse Models
      
IDs
 View 5 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    66 phenotypes from 6 alleles in 7 genetic backgrounds
    29 phenotypes from multigenic genotypes
    1 images
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit agenesis of both the urinary bladder and the caudal portion of the Mullerian ducts, premature stenosis of the umbilical arteries, loss of the most anterior digit of all feet, and death around mid-gestation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1294
  • Tissues
    287
  • cDNA Data
    9
  • Literature Summary
    117
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      33
    • RefSeq
      2
    • UniProt
      5
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15398 NCBI Gene Model | MGI Sequence Detail 2033 C57BL/6J ±  kb
    transcript NM_008264 RefSeq | MGI Sequence Detail 1318 Not Specified  
    polypeptide Q62424 UniProt | EBI | MGI Sequence Detail 386 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      Genomic 10
      cDNA 9
      Primer pair 12
      Other 22

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10679, MGD-MRK-10816, MGD-MRK-10874, MGI:96061
    References
    more
    • Summaries
      All 187
      Developmental Gene Expression 117
      Diseases 5
      Gene Ontology 16
      Phenotypes 54
    • Earliest
      J:5211 Hummel KP, Hypodactyly, a semidominant lethal mutation in mice. J Hered. 1970 Sep-Oct;61(5):219-20
    • Latest
      J:334522 Fuiten AM, et al., Digits in a dish: An in vitro system to assess the molecular genetics of hand/foot development at single-cell resolution. Front Cell Dev Biol. 2023;11:1135025
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory