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Hoxa3 Gene Detail
Summary
  • Symbol
    Hoxa3
  • Name
    homeobox A3
  • Synonyms
    Hox-1.5, Mo-10
  • Feature Type
    protein coding gene
  • IDs
    MGI:96175
    NCBI Gene: 15400
  • Member of
    Hoxa cluster
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:52146042-52190316 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 25.40 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    618 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96175
 protein coding gene Chr6:52146039-52190316 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030741
 protein coding gene Chr6:51404462-51454496 (-)
A/J MGP_AJ_G0030711
 protein coding gene Chr6:49004592-49049182 (-)
AKR/J MGP_AKRJ_G0030637
 protein coding gene Chr6:50710034-50755614 (-)
BALB/cJ MGP_BALBcJ_G0030722
 protein coding gene Chr6:49363938-49409856 (-)
C3H/HeJ MGP_C3HHeJ_G0030436
 protein coding gene Chr6:50718786-50764655 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031177
 protein coding gene Chr6:52542036-52590780 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028384
 protein coding gene Chr6:46652673-46697007 (-)
CAST/EiJ MGP_CASTEiJ_G0029838
 protein coding gene Chr6:50530846-50579613 (-)
CBA/J MGP_CBAJ_G0030409
 protein coding gene Chr6:54740197-54788779 (-)
DBA/2J MGP_DBA2J_G0030559
 protein coding gene Chr6:48927551-48971615 (-)
FVB/NJ MGP_FVBNJ_G0030511
 protein coding gene Chr6:48537607-48582083 (-)
LP/J MGP_LPJ_G0030644
 protein coding gene Chr6:51389237-51433221 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030545
 protein coding gene Chr6:57373822-57419602 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031207
 protein coding gene Chr6:50635627-50684282 (-)
PWK/PhJ MGP_PWKPhJ_G0029551
 protein coding gene Chr6:48549536-48595457 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029386
 protein coding gene Chr6:49972445-50019709 (-)
WSB/EiJ MGP_WSBEiJ_G0029915
 protein coding gene Chr6:50651817-50700450 (-)



Homology
more
  • Human Ortholog
    HOXA3, homeobox A3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOXA3, homeobox A3
  • Synonyms
    HOX1, HOX1E
  • Links
    NCBI Gene ID: 3200
    neXtProt AC: NX_O43365
    UniProt: O43365

  • Chr Location
    7p15.2; chr7:27106184-27152583 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hoxa3 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    55 phenotypes from 7 alleles in 7 genetic backgrounds
    50 phenotypes from multigenic genotypes
    1 images
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations are athymic, aparathyroid, and exhibit reduced thyroid and submaxillary glands, defects of the IXth nerve, and frequently, heart and artery abnormalities. Mutants die neonatally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1220
  • Tissues
    265
  • cDNA Data
    18
  • Literature Summary
    99
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079560 Ensembl Gene Model | MGI Sequence Detail 44275 C57BL/6J ±  kb
    transcript ENSMUST00000114434 Ensembl | MGI Sequence Detail 2591 Not Applicable  
    polypeptide ENSMUSP00000110077 Ensembl | MGI Sequence Detail 443 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 17
      cDNA 20
      Primer pair 9
      Other 12

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-10821, MGD-MRK-10876
    References
    more
    • Summaries
      All 190
      Developmental Gene Expression 99
      Diseases 1
      Gene Ontology 17
      Phenotypes 53
    • Earliest
      J:7605 McGinnis W, et al., Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila. Cell. 1984 Oct;38(3):675-80
    • Latest
      J:344102 Racedo SE, et al., Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals. Dev Biol. 2024 Feb;506:72-84
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory