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Hoxb4 Gene Detail
Summary
  • Symbol
    Hoxb4
  • Name
    homeobox B4
  • Synonyms
    Hox-2.6
  • Feature Type
    protein coding gene
  • IDs
    MGI:96185
    NCBI Gene: 15412
  • Member of
    Hoxb cluster
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
  • Regulated by
    Rr6, Rr5, Rr577 ... (4 regulatory regions)
Location &
Maps
more
  • Sequence Map
    Chr11:96209093-96212464 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 59.83 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    71 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96185
 protein coding gene Chr11:96209093-96212464 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019006
 protein coding gene Chr11:98631428-98634798 (+)
A/J MGP_AJ_G0018974
 protein coding gene Chr11:94602853-94606195 (+)
AKR/J MGP_AKRJ_G0018944
 protein coding gene Chr11:97529020-97532359 (+)
BALB/cJ MGP_BALBcJ_G0018947
 protein coding gene Chr11:95102551-95105921 (+)
C3H/HeJ MGP_C3HHeJ_G0018761
 protein coding gene Chr11:97660260-97663647 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019399
 protein coding gene Chr11:101712530-101715775 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017029
 protein coding gene Chr11:92089440-92092789 (+)
CAST/EiJ MGP_CASTEiJ_G0018314
 protein coding gene Chr11:98483906-98489079 (+)
CBA/J MGP_CBAJ_G0018732
 protein coding gene Chr11:105874324-105877654 (+)
DBA/2J MGP_DBA2J_G0018840
 protein coding gene Chr11:94170292-94173660 (+)
FVB/NJ MGP_FVBNJ_G0018829
 protein coding gene Chr11:93649032-93652368 (+)
LP/J MGP_LPJ_G0018910
 protein coding gene Chr11:99167468-99170835 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018856
 protein coding gene Chr11:105869807-105873174 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019439
 protein coding gene Chr11:97836484-97839846 (+)
PWK/PhJ MGP_PWKPhJ_G0018086
 protein coding gene Chr11:95121708-95125303 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017875
 protein coding gene Chr11:97563014-97567198 (+)
WSB/EiJ MGP_WSBEiJ_G0018364
 protein coding gene Chr11:97722765-97728097 (+)



Homology
more
  • Human Ortholog
    HOXB4, homeobox B4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOXB4, homeobox B4
  • Synonyms
    HOX2, HOX-2.6, HOX2F
  • Links
    NCBI Gene ID: 3214
    neXtProt AC: NX_P17483
    UniProt: P17483

  • Chr Location
    17q21.32; chr17:48575507-48578350 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 8 alleles in 6 genetic backgrounds
    10 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene causes cervical vertebral transformation and may lead to pre- or neonatal lethality, sternal defects, impaired ventral body wall formation, diaphragm hernias and heart anomalies. Homozygotes for a null allele show a proliferation defect in hematopoietic stem cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1225
  • Tissues
    303
  • cDNA Data
    25
  • Literature Summary
    105
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15412 NCBI Gene Model | MGI Sequence Detail 3372 C57BL/6J ±  kb
    transcript NM_010459 RefSeq | MGI Sequence Detail 2566 ZRU/MplStud  
    polypeptide P10284 UniProt | EBI | MGI Sequence Detail 250 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 78
      Genomic 20
      cDNA 34
      Primer pair 8
      Other 16

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10834, MGD-MRK-10886
    References
    more
    • Summaries
      All 184
      Developmental Gene Expression 105
      Gene Ontology 16
      Phenotypes 24
    • Earliest
      J:8920 Lonai P, et al., New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis. DNA. 1987 Oct;6(5):409-18
    • Latest
      J:360527 Frenette B, et al., Loss of Hoxa5 function affects Hox gene expression in different biological contexts. Sci Rep. 2024 Dec 28;14(1):30903
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory