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Hpd Gene Detail
Summary
  • Symbol
    Hpd
  • Name
    4-hydroxyphenylpyruvic acid dioxygenase
  • Synonyms
    Flp, Hppd, Laf
  • Feature Type
    protein coding gene
  • IDs
    MGI:96213
    NCBI Gene: 15445
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:123309870-123320786 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 62.82 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    361 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96213
 protein coding gene Chr5:123309870-123320790 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030067
 protein coding gene Chr5:126860775-126871691 (-)
A/J MGP_AJ_G0030032
 protein coding gene Chr5:121605310-121616224 (-)
AKR/J MGP_AKRJ_G0029968
 protein coding gene Chr5:125522680-125533619 (-)
BALB/cJ MGP_BALBcJ_G0030043
 protein coding gene Chr5:122939807-122950699 (-)
C3H/HeJ MGP_C3HHeJ_G0029760
 protein coding gene Chr5:126147582-126160498 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030496
 protein coding gene Chr5:131753110-131763989 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027722
 protein coding gene Chr5:116187979-116199166 (-)
CAST/EiJ MGP_CASTEiJ_G0029169
 protein coding gene Chr5:125253816-125264797 (-)
CBA/J MGP_CBAJ_G0029730
 protein coding gene Chr5:136924506-136939134 (-)
DBA/2J MGP_DBA2J_G0029880
 protein coding gene Chr5:121651539-121662829 (-)
FVB/NJ MGP_FVBNJ_G0029836
 protein coding gene Chr5:120653474-120664851 (-)
LP/J MGP_LPJ_G0029969
 protein coding gene Chr5:127395678-127406584 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029867
 protein coding gene Chr5:140599448-140611204 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030537
 protein coding gene Chr5:125126200-125137119 (-)
PWK/PhJ MGP_PWKPhJ_G0028883
 protein coding gene Chr5:120440080-120451717 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028720
 protein coding gene Chr5:122813271-122827163 (-)
WSB/EiJ MGP_WSBEiJ_G0029244
 protein coding gene Chr5:125788833-125800576 (-)



Homology
more
  • Human Ortholog
    HPD, 4-hydroxyphenylpyruvate dioxygenase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HPD, 4-hydroxyphenylpyruvate dioxygenase
  • Synonyms
    4-HPPD, 4HPPD, GLOD3, HPPD, HPPDASE, PPD
  • Links
    NCBI Gene ID: 3242
    neXtProt AC: NX_P32754
    UniProt: P32754

  • Chr Location
    12q24.31; chr12:121839527-121888611 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hpd mouse models; 2 with human HPD associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
CBA, C3H, DBA/2, SM and AKR have the F.1 form of this soluble liver antigen; A/J, A2G, BALB/c and C57BL/10 the F.2 form. F.2 antigen induces precipitating antibodies in F.1 but not F.2 strains and vice versa. F antigen immune response requires H2 Kk or Ak alleles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    826
  • Tissues
    96
  • cDNA Data
    193
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15445 NCBI Gene Model | MGI Sequence Detail 10917 C57BL/6J ±  kb
    transcript NM_008277 RefSeq | MGI Sequence Detail 1400 ZRU/MplStud  
    polypeptide P49429 UniProt | EBI | MGI Sequence Detail 393 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008730 4-hydroxyphenylpyruvate dioxygenase
      (term hierarchy)
    • EC
      1.13.11.24, 1.13.11.27
    • InterPro Domains
      IPR005956 4-hydroxyphenylpyruvate dioxygenase
      IPR041735 4-hydroxyphenylpyruvate dioxygenase, C-terminal
      IPR041736 4-hydroxyphenylpyruvate dioxygenase, N-terminal
      IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
      IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain
      IPR037523 Vicinal oxygen chelate (VOC) domain
    • GlyGen
      P49429 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 196
      Genomic 1
      cDNA 193
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10914, MGD-MRK-10921, MGD-MRK-11728, MGD-MRK-9821, MGD-MRK-9831, MGI:95551
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 9
      Phenotypes 19
    • Earliest
      J:5062 Fravi G, et al., Induction by allogeneic extracts of liver-specific precipitating autoantibodies in the mouse. Nature. 1968 Apr 13;218(137):141-3
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory