Ranbp1 MGI Mouse Gene Detail - MGI:96269

Symbol

Ranbp1
Name

RAN binding protein 1
Synonyms

Htf9a

Feature Type

protein coding gene
IDs

MGI:96269
NCBI Gene: 19385
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr16:18057843-18066558 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 11.30 cM
Mapping Data

6 experiments

Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96269	protein coding gene	Chr16:18057648-18066596 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022605	protein coding gene	Chr16:15447047-15455910 (-)
A/J	MGP_AJ_G0022566	protein coding gene	Chr16:14683631-14692494 (-)
AKR/J	MGP_AKRJ_G0022543	protein coding gene	Chr16:15260075-15270583 (-)
BALB/cJ	MGP_BALBcJ_G0022571	protein coding gene	Chr16:14832992-14841903 (-)
C3H/HeJ	MGP_C3HHeJ_G0022338	protein coding gene	Chr16:15425324-15434187 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023020	protein coding gene	Chr16:15715617-15726099 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020540	protein coding gene	Chr16:14734397-14743493 (-)
CAST/EiJ	MGP_CASTEiJ_G0021865	protein coding gene	Chr16:15312503-15322803 (-)
CBA/J	MGP_CBAJ_G0022307	protein coding gene	Chr16:16403151-16412060 (-)
DBA/2J	MGP_DBA2J_G0022439	protein coding gene	Chr16:14595032-14603934 (-)
FVB/NJ	MGP_FVBNJ_G0022414	protein coding gene	Chr16:14652213-14661212 (-)
LP/J	MGP_LPJ_G0022506	protein coding gene	Chr16:15230911-15239774 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022436	protein coding gene	Chr16:16054750-16063610 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023031	protein coding gene	Chr16:15198747-15207654 (-)
PWK/PhJ	MGP_PWKPhJ_G0021607	protein coding gene	Chr16:14865459-14874497 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021435	protein coding gene	Chr16:15165971-15176390 (-)
WSB/EiJ	MGP_WSBEiJ_G0021911	protein coding gene	Chr16:15181942-15190857 (-)

Human Ortholog

RANBP1, RAN binding protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RANBP1, RAN binding protein 1
Synonyms

HTF9A
Links

HGNC:9847

NCBI Gene ID: 5902

neXtProt AC: NX_P43487

UniProt: P43487
Chr Location

22q11.21; chr22:20115938-20127355 (+) GRCh38

MGI Vertebrate Homology

Ranbp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RANBP1
Gene Tree

Ranbp1

less

References

6 with disease annotations

less

Phenotype Summary

39 phenotypes from 3 alleles in 3 genetic backgrounds
141 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

44
Endonuclease-mediated

6
Gene trapped

24
Targeted

14
Genomic Mutations

12 involving Ranbp1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

69 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit postnatal growth retardation, decreased body weight, impaired spermatogenesis, and male infertility.

less

All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

815
Tissues

55
cDNA Data

69
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ranbp1

ZFIN ranbp1

less

All Sequences

46
RefSeq

2
UniProt

3
CCDS

CCDS37280.1

Ensembl

ENSMUSG00000005732 (Evidence)
NCBI Gene

19385

			Length	Strain/Species	Flank
genomic	19385	NCBI Gene Model \| MGI Sequence Detail	8716	C57BL/6J	± kb
transcript	NM_011239	RefSeq \| MGI Sequence Detail	852	ZRU/MplStud
polypeptide	P34022	UniProt \| EBI \| MGI Sequence Detail	203	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000013709 Ran-specific GTPase-activating protein

(term hierarchy)
InterPro Domains

IPR011993 PH-like domain superfamily

IPR000156 Ran binding domain

IPR045255 Ran binding protein RanBP1-like

IPR045256 Ran-specific GTPase-activating protein 1, Ran-binding domain
GlyGen

P34022 1 site, 1 O-linked glycan (1 site)

less

All nucleic 87

Genomic 14

cDNA 71

Primer pair 2

Microarray probesets 3

less

MGD-MRK-10994

Summaries

All 185

Developmental Gene Expression 12

Diseases 6

Gene Ontology 7

Phenotypes 141
Earliest

J:17925 Bird A, et al., A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA. Cell. 1985 Jan;40(1):91-9
Latest

J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599

TSS for Ranbp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr140238	Chr16:18067095-18067117 (-)	-548 bp
Tssr140237	Chr16:18066591-18066608 (-)	-42 bp
Tssr140236	Chr16:18066561-18066573 (-)	-9 bp
Tssr140235	Chr16:18066475-18066556 (-)	42 bp
Tssr140234	Chr16:18065268-18065283 (-)	1,282 bp
Tssr140233	Chr16:18065230-18065251 (-)	1,317 bp
Tssr140232	Chr16:18063089-18063102 (-)	3,462 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24