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Htr1a Gene Detail
Summary
  • Symbol
    Htr1a
  • Name
    5-hydroxytryptamine (serotonin) receptor 1A
  • Synonyms
    5-HT1A receptor, Gpcr18
  • Feature Type
    protein coding gene
  • IDs
    MGI:96273
    NCBI Gene: 15550
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:105580147-105584630 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 56.92 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    212 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96273
 protein coding gene Chr13:105580040-105584630 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020915
 protein coding gene Chr13:107595533-107599973 (+)
A/J MGP_AJ_G0020866
 protein coding gene Chr13:103399286-103403726 (+)
AKR/J MGP_AKRJ_G0020841
 protein coding gene Chr13:106537542-106541982 (+)
BALB/cJ MGP_BALBcJ_G0020866
 protein coding gene Chr13:104121074-104125515 (+)
C3H/HeJ MGP_C3HHeJ_G0020655
 protein coding gene Chr13:106298859-106303299 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021300
 protein coding gene Chr13:110827600-110832040 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018870
 protein coding gene Chr13:98973713-98978155 (+)
CAST/EiJ MGP_CASTEiJ_G0020174
 protein coding gene Chr13:105833480-105837554 (+)
CBA/J MGP_CBAJ_G0020617
 protein coding gene Chr13:115141484-115145924 (+)
DBA/2J MGP_DBA2J_G0020741
 protein coding gene Chr13:103161244-103165685 (+)
FVB/NJ MGP_FVBNJ_G0020723
 protein coding gene Chr13:101850394-101854835 (+)
LP/J MGP_LPJ_G0020815
 protein coding gene Chr13:107631094-107635534 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020751
 protein coding gene Chr13:115408457-115412897 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021339
 protein coding gene Chr13:106033510-106037975 (+)
PWK/PhJ MGP_PWKPhJ_G0019927
 protein coding gene Chr13:101897264-101901310 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019749
 protein coding gene Chr13:102257315-102309904 (+)
WSB/EiJ MGP_WSBEiJ_G0020232
 protein coding gene Chr13:106502742-106507183 (+)



Homology
more
  • Human Ortholog
    HTR1A, 5-hydroxytryptamine receptor 1A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HTR1A, 5-hydroxytryptamine receptor 1A
  • Synonyms
    5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD
  • Links
    NCBI Gene ID: 3350
    neXtProt AC: NX_P08908
    UniProt: P08908

  • Chr Location
    5q12.3; chr5:63957874-63962507 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Htr1a mouse models; 6 with human HTR1A associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 5 alleles in 7 genetic backgrounds
    6 phenotypes from multigenic genotypes
    95 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations show a common phenotype, including augmented anxious-like behavior in the elevated plus-maze, open-field, and novel object tests, reduced immobility in the forced-swim or tail-suspension test, and changes in density of 5-HTT binding in several brain regions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    976
  • Tissues
    153
  • cDNA Data
    14
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021721 Ensembl Gene Model | MGI Sequence Detail 4484 C57BL/6J ±  kb
    transcript ENSMUST00000022235 Ensembl | MGI Sequence Detail 4484 Not Applicable  
    polypeptide ENSMUSP00000022235 Ensembl | MGI Sequence Detail 421 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 2
      cDNA 17
      Primer pair 4
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10999, MGD-MRK-16345, MGI:99565
    References
    more
    • Summaries
      All 199
      Developmental Gene Expression 14
      Diseases 2
      Gene Ontology 11
      Phenotypes 95
    • Earliest
      J:10019 Sundaresan S, et al., Genes for HMG-CoA reductase and serotonin 1a receptor are on mouse chromosome 13. Somat Cell Mol Genet. 1989 Sep;15(5):465-9
    • Latest
      J:355189 Saraf TS, et al., Altered brain serotonin 5-HT(1A) receptor expression and function in juvenile Fmr1 knockout mice. Neuropharmacology. 2024 Mar 1;245:109774
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory