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Htr3a Gene Detail
Summary
  • Symbol
    Htr3a
  • Name
    5-hydroxytryptamine (serotonin) receptor 3A
  • Synonyms
    5-HT3 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:96282
    NCBI Gene: 15561
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:48810513-48822399 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 26.53 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    467 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96282
 protein coding gene Chr9:48810513-48822451 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034765
 protein coding gene Chr9:47691581-47703447 (-)
A/J MGP_AJ_G0034746
 protein coding gene Chr9:46282188-46294297 (-)
AKR/J MGP_AKRJ_G0034674
 protein coding gene Chr9:47242579-47254467 (-)
BALB/cJ MGP_BALBcJ_G0034738
 protein coding gene Chr9:46003479-46015598 (-)
C3H/HeJ MGP_C3HHeJ_G0034448
 protein coding gene Chr9:47700667-47713742 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035258
 protein coding gene Chr9:49051874-49064733 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032171
 protein coding gene Chr9:45775734-45788117 (-)
CAST/EiJ MGP_CASTEiJ_G0033770
 protein coding gene Chr9:47646707-47658591 (-)
CBA/J MGP_CBAJ_G0034420
 protein coding gene Chr9:50795193-50807075 (-)
DBA/2J MGP_DBA2J_G0034579
 protein coding gene Chr9:46132135-46145115 (-)
FVB/NJ MGP_FVBNJ_G0034520
 protein coding gene Chr9:45386242-45398108 (-)
LP/J MGP_LPJ_G0034660
 protein coding gene Chr9:48064190-48076072 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034564
 protein coding gene Chr9:52486988-52499867 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035279
 protein coding gene Chr9:47185492-47197375 (-)
PWK/PhJ MGP_PWKPhJ_G0033475
 protein coding gene Chr9:46101809-46113907 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033310
 protein coding gene Chr9:47499983-47511905 (-)
WSB/EiJ MGP_WSBEiJ_G0033883
 protein coding gene Chr9:47218227-47230403 (-)



Homology
more
  • Human Ortholog
    HTR3A, 5-hydroxytryptamine receptor 3A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HTR3A, 5-hydroxytryptamine receptor 3A
  • Synonyms
    5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3
  • Links
    NCBI Gene ID: 3359
    neXtProt AC: NX_P46098
    UniProt: P46098

  • Chr Location
    11q23.2; chr11:113975075-113990313 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human HTR3A associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    25 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice display a decreased lifespan, cachexia, increased blood urea nitrogen, proteinuria, kidney inflammation, and a hyperdistended and neurogenic urinary bladder. Mice homozygous for a second null mutation display reduced chemical pain persistence responses but are otherwise healthy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    855
  • Tissues
    86
  • cDNA Data
    14
  • Literature Summary
    20
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032269 Ensembl Gene Model | MGI Sequence Detail 11887 C57BL/6J ±  kb
transcript ENSMUST00000003826 Ensembl | MGI Sequence Detail 2082 Not Applicable  
polypeptide ENSMUSP00000003826 Ensembl | MGI Sequence Detail 489 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    Genomic 6
    cDNA 14
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11009
References
more
  • Summaries
    All 115
    Developmental Gene Expression 20
    Gene Ontology 15
    Phenotypes 40
  • Earliest
    J:17543 Maricq AV, et al., Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Science. 1991 Oct 18;254(5030):432-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory