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Icam1 Gene Detail
Summary
  • Symbol
    Icam1
  • Name
    intercellular adhesion molecule 1
  • Synonyms
    CD54, Icam-1, Ly-47, MALA-2, MGC:6195
  • Feature Type
    protein coding gene
  • IDs
    MGI:96392
    NCBI Gene: 15894
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:20927281-20940113 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.69 cM
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • SNPs within 2kb
    362 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96392
 protein coding gene Chr9:20927236-20940113 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034435
 protein coding gene Chr9:18192793-18209953 (+)
A/J MGP_AJ_G0034413
 protein coding gene Chr9:17892533-17907825 (+)
AKR/J MGP_AKRJ_G0034340
 protein coding gene Chr9:18215241-18229631 (+)
BALB/cJ MGP_BALBcJ_G0034404
 protein coding gene Chr9:17788102-17802021 (+)
C3H/HeJ MGP_C3HHeJ_G0034116
 protein coding gene Chr9:18526860-18540629 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034925
 protein coding gene Chr9:18924310-18938289 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031855
 protein coding gene Chr9:17020609-17032809 (+)
CAST/EiJ MGP_CASTEiJ_G0033439
 protein coding gene Chr9:18353575-18367741 (+)
CBA/J MGP_CBAJ_G0034089
 protein coding gene Chr9:19636406-19649074 (+)
DBA/2J MGP_DBA2J_G0034248
 protein coding gene Chr9:17876485-17889618 (+)
FVB/NJ MGP_FVBNJ_G0034191
 protein coding gene Chr9:17385507-17398253 (+)
LP/J MGP_LPJ_G0034333
 protein coding gene Chr9:18369563-18383544 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034234
 protein coding gene Chr9:21255451-21271231 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034945
 protein coding gene Chr9:18166636-18179400 (+)
PWK/PhJ MGP_PWKPhJ_G0033145
 protein coding gene Chr9:17845693-17859093 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032979
 protein coding gene Chr9:18216393-18229164 (+)
WSB/EiJ MGP_WSBEiJ_G0033554
 protein coding gene Chr9:17904013-17916819 (+)



Homology
more
  • Human Ortholog
    ICAM1, intercellular adhesion molecule 1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ICAM1, intercellular adhesion molecule 1
  • Synonyms
    BB2, CD54, P3.58
  • Links
    NCBI Gene ID: 3383
    neXtProt AC: NX_P05362
    UniProt: P05362

  • Chr Location
    19p13.2; chr19:10271093-10286615 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Icam1 mouse models; 16 with human ICAM1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
 View 1 "NOT" model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 4 alleles in 10 genetic backgrounds
    31 phenotypes from multigenic genotypes
    242 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired inflammatory and immune responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    788
  • Tissues
    37
  • cDNA Data
    41
  • Literature Summary
    47
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037405 Ensembl Gene Model | MGI Sequence Detail 12833 C57BL/6J ±  kb
    transcript ENSMUST00000086399 Ensembl | MGI Sequence Detail 2535 Not Applicable  
    polypeptide ENSMUSP00000083587 Ensembl | MGI Sequence Detail 537 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      13 Sequences
    • Protein Ontology
      PR:000001467 intercellular adhesion molecule 1
      (term hierarchy)
    • InterPro Domains
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003599 Immunoglobulin subtype
      IPR003988 Intercellular adhesion molecule
      IPR048679 Intercellular adhesion molecule 1/3/5, D2 domain
      IPR013768 Intercellular adhesion molecule, N-terminal
      IPR047012 Intercellular adhesion molecule/vascular cell adhesion molecule
      IPR003987 Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
    • GlyGen
      P13597 10 sites, 6 N-linked glycans (6 sites)
    Molecular
    Reagents
    less
    • All nucleic 52
      Genomic 5
      cDNA 42
      Primer pair 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11146, MGD-MRK-11148, MGD-MRK-11989
    References
    more
    • Summaries
      All 474
      Developmental Gene Expression 47
      Diseases 2
      Gene Ontology 19
      Phenotypes 242
    • Earliest
      J:9934 Ballantyne CM, et al., Nucleotide sequence of the cDNA for murine intercellular adhesion molecule-1 (ICAM-1). Nucleic Acids Res. 1989 Jul 25;17(14):5853
    • Latest
      J:353591 Lyons-Cohen MR, et al., Site-specific regulation of Th2 differentiation within lymph node microenvironments. J Exp Med. 2024 Apr 1;221(4)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory