About   Help   FAQ
Ids Gene Detail
Summary
  • Symbol
    Ids
  • Name
    iduronate 2-sulfatase
  • Feature Type
    protein coding gene
  • IDs
    MGI:96417
    NCBI Gene: 15931
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:69386675-69408690 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 36.01 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    531 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96417
 protein coding gene ChrX:69386675-69429437 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035776
 protein coding gene ChrX:65951921-65975849 (-)
A/J MGP_AJ_G0035759
 protein coding gene ChrX:66105247-66130044 (-)
AKR/J MGP_AKRJ_G0035680
 protein coding gene ChrX:67877924-67900249 (-)
BALB/cJ MGP_BALBcJ_G0035746
 protein coding gene ChrX:65288866-65311640 (-)
C3H/HeJ MGP_C3HHeJ_G0035449
 protein coding gene ChrX:66399783-66425845 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036276
 protein coding gene ChrX:67960062-67981480 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033125
 protein coding gene ChrX:65004646-65025988 (-)
CAST/EiJ MGP_CASTEiJ_G0034741
 protein coding gene ChrX:51867723-51892146 (-)
CBA/J MGP_CBAJ_G0035424
 protein coding gene ChrX:69824622-69849878 (-)
DBA/2J MGP_DBA2J_G0035577
 protein coding gene ChrX:65660980-65687929 (-)
FVB/NJ MGP_FVBNJ_G0035528
 protein coding gene ChrX:65105876-65127609 (-)
LP/J MGP_LPJ_G0035665
 protein coding gene ChrX:66726964-66749519 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035563
 protein coding gene ChrX:72366731-72395059 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036297
 protein coding gene ChrX:65791407-65814226 (-)
PWK/PhJ MGP_PWKPhJ_G0034441
 protein coding gene ChrX:49933844-49955519 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034279
 protein coding gene ChrX:52868609-52891159 (-)
WSB/EiJ MGP_WSBEiJ_G0034883
 protein coding gene ChrX:65114264-65139502 (-)



Homology
more
  • Human Ortholog
    IDS, iduronate 2-sulfatase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IDS, iduronate 2-sulfatase
  • Synonyms
    ID2S, MPS2, SIDS
  • Links
    NCBI Gene ID: 3423
    neXtProt AC: NX_P22304
    UniProt: P22304

  • Chr Location
    Xq28; chrX:149476988-149521096 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ids mouse models; 1 with human IDS associations

Human Disease Mouse Models
      
IDs
 View 5 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    74 phenotypes from 3 alleles in 3 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with homozygous disruption of this gene display lysosomal accumulation of glycosaminoglycans in multiple tissues, premature death, impaired locomotor activity, joint swelling, and skeletal defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    15
  • cDNA Data
    66
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035847 Ensembl Gene Model | MGI Sequence Detail 22016 C57BL/6J ±  kb
    transcript ENSMUST00000101509 Ensembl | MGI Sequence Detail 4972 Not Applicable  
    polypeptide ENSMUSP00000099046 Ensembl | MGI Sequence Detail 552 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      Genomic 2
      cDNA 68

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGD-MRK-11187, MGI:2148005
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 1
      Diseases 6
      Gene Ontology 10
      Phenotypes 25
    • Earliest
      J:11526 Habara-Ohkubo A, et al., Cloning and expression of a cDNA encoding mouse indoleamine 2,3-dioxygenase. Gene. 1991 Sep 15;105(2):221-7
    • Latest
      J:343337 Mashima R, et al., A novel mucopolysaccharidosis type II mouse model with an iduronate-2-sulfatase-P88L mutation. Sci Rep. 2023 May 15;13(1):7865
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory