If2 Gene Detail

Summary

• Symbol
  If2
• Name
  MTV-induced circulating interferon
• Synonyms
  If-2

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:96421
  NCBI Gene: 107627
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome Unknown

Mutations,
Alleles, and
Phenotypes

This locus affects quantitative response to mouse mammary tumor virus. C57BL/6 responds producing a high level of interferon; BALB/c produces a low level. Heterozygotes have low levels. Interferon level is but one factor contributing to differences in resistance to MMTV in these strains.

Sequences &
Gene Models

• NCBI Gene
  107627

Other
Accession IDs

MGD-MRK-11191, MGD-MRK-11196

References

• Summaries
  All 4
• Earliest
  J:5457 Maeyer E de, et al., A locus affecting circulating interferon levels induced by mouse mammary tumour virus. J Gen Virol. 1974 May;23(2):209-11
• Latest
  J:6183 Slate DL, et al., Genetics of the interferon system. Pharmacol Ther. 1979;4(1):221-30