Ifi203 MGI Mouse Gene Detail - MGI:96428 - interferon activated gene 203

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Ifi203 Gene Detail

Symbol

Ifi203
Name

interferon activated gene 203

Feature Type

protein coding gene
IDs

MGI:96428
NCBI Gene: 15950
Alliance

gene page
Transcription Start Sites

10 TSS
Candidate for QTL

4 QTL

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Sequence Map

Chr1:173747973-173770238 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 80.76 cM
Mapping Data

14 experiments

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SNPs within 2kb

99 from dbSNP Build 142
Strain Annotations

12
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_96428	protein coding gene	Chr1:173747966-173770432 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016816	protein coding gene	Chr1:179851944-179858080 (-)
A/J	MGP_AJ_G0016792	protein coding gene	Chr1:172455142-172653559 (-)
AKR/J	no annotation
BALB/cJ	MGP_BALBcJ_G0016754	protein coding gene	Chr1:173158368-173180798 (-)
C3H/HeJ	MGP_C3HHeJ_G0016576	protein coding gene	Chr1:178261882-178312288 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017215	protein coding gene	Chr1:185766457-186008411 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014924	protein coding gene	Chr1:164166749-164172649 (-)
CAST/EiJ	MGP_CASTEiJ_G0016159	protein coding gene	Chr1:177724504-177731544 (-)
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	MGP_FVBNJ_G0016653	protein coding gene	Chr1:169685606-169706071 (-)
LP/J	MGP_LPJ_G0016731	protein coding gene	Chr1:180813820-181035305 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016683	protein coding gene	Chr1:199700440-199708543 (-)
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0016221	protein coding gene	Chr1:177627681-177635414 (-)

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Human Ortholog

IFI16, interferon gamma inducible protein 16

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IFI16, interferon gamma inducible protein 16
Synonyms

IFNGIP1, PYHIN2
Links

HGNC:5395

NCBI Gene ID: 3428

neXtProt AC: NX_Q16666

UniProt: Q16666
Chr Location

1q23.1; chr1:158999968-159055155 (+) GRCh38

MGI Vertebrate Homology

Ifi203 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: IFI16
Gene Tree

Ifi203

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Phenotype Summary

6 phenotype references

All Mutations and Alleles

4
Chemically induced (other)

2
Endonuclease-mediated

1
Targeted

1
Genomic Mutations

3 involving Ifi203
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

45 strains or lines available

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All GO Annotations

34
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

17

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

73
RefSeq

22
UniProt

4
CCDS

CCDS35793.1, CCDS48453.1, CCDS78754.1

Ensembl

ENSMUSG00000039997 (Evidence)
NCBI Gene

15950

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000039997	Ensembl Gene Model \| MGI Sequence Detail	22266	C57BL/6J	± kb
	transcript	ENSMUST00000129829	Ensembl \| MGI Sequence Detail	3054	Not Applicable
	polypeptide	ENSMUSP00000122424	Ensembl \| MGI Sequence Detail	871	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009173 interferon-activable protein 203

(term hierarchy)
InterPro Domains

IPR004020 DAPIN domain

IPR011029 Death-like domain superfamily

IPR040205 HIN-200 family

IPR004021 HIN-200/IF120x

IPR012340 Nucleic acid-binding, OB-fold

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All nucleic 24

Genomic 6

cDNA 18

Microarray probesets 5

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MGD-MRK-11221

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Summaries

All 38

Gene Ontology 5

Phenotypes 6
Earliest

J:9335 Engel DA, et al., Interferons as gene activators: close linkage of two interferon-activatable murine genes. Virology. 1988 Sep;166(1):24-9
Latest

J:329937 Maltbaek JH, et al., ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP. Immunity. 2022 Oct 11;55(10):1799-1812.e4

TSS for Ifi203:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15350	Chr1:173770011-173770038 (-)	213 bp
Tssr15349	Chr1:173768195-173768204 (-)	2,038 bp
Tssr15348	Chr1:173765410-173765418 (-)	4,824 bp
Tssr15347	Chr1:173761024-173761034 (-)	9,209 bp
Tssr15346	Chr1:173756627-173756645 (-)	13,602 bp
Tssr15345	Chr1:173751408-173751411 (-)	18,828 bp
Tssr15344	Chr1:173750652-173750664 (-)	19,580 bp
Tssr15343	Chr1:173749604-173749630 (-)	20,621 bp
Tssr15342	Chr1:173749213-173749237 (-)	21,013 bp
Tssr15341	Chr1:173748814-173748864 (-)	21,399 bp

Ifi203 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Lmr20	Chr1, syntenic	Chr1:175468817-175468938	J:152405	Potential candidated genes mapping near Lmr20, Lmr20a, Lmr20b and Lmr20c which mapped to D1Mit403 at 100.0 cM of CcS11/Dem in this study are: Fcer1a, Fc receptor, IgE, high affinity I, alpha polypeptide at 94.2 cM; Fcer1g, Fc receptor, IgE, high affinity I, gamma polypeptide at 93.3 cM; Fcgr2b, Fc receptor, IgG, low affinity IIb at 92.3 cM; Cluster of IFN activated genes: Ifi201,Ifi202a; Ifi203, and Ifi204 between 95.2-95.3 cM; and Tgfb2, transforming growth factor, beta 2 at 101.5 cM. [Table 9.] Possibly related QTL controlling other infections and co-localizing with the Lmr20 QTL are: Tir3c, trypanosome infection response 3c at 93.0 cM; Ssta2, susceptibility to Salmonella typhimurium antigens 2 at 95.8 cM; Bbaa12, B.burgdorferi-associated arthritis 12 at 96.0 cM; and, Berr1, berghei resistance locus 1 at 102.0 cM; [Table 10].
Lmr20a	Chr1, syntenic	Chr1:175468817-175468938	J:152405	Potential candidated genes mapping near Lmr20, Lmr20a, Lmr20b and Lmr20c which mapped to D1Mit403 at 100.0 cM of CcS11/Dem in this study are: Fcer1a, Fc receptor, IgE, high affinity I, alpha polypeptide at 94.2 cM; Fcer1g, Fc receptor, IgE, high affinity I, gamma polypeptide at 93.3 cM; Fcgr2b, Fc receptor, IgG, low affinity IIb at 92.3 cM; Cluster of IFN activated genes: Ifi201,Ifi202a; Ifi203, and Ifi204 between 95.2-95.3 cM; and Tgfb2, transforming growth factor, beta 2 at 101.5 cM. [Table 9.] Possibly related QTL controlling other infections and co-localizing with the Lmr20 QTL are: Tir3c, trypanosome infection response 3c at 93.0 cM; Ssta2, susceptibility to Salmonella typhimurium antigens 2 at 95.8 cM; Bbaa12, B.burgdorferi-associated arthritis 12 at 96.0 cM; and, Berr1, berghei resistance locus 1 at 102.0 cM; [Table 10].
Lmr20b	Chr1, syntenic	Chr1:175468817-175468938	J:152405	Potential candidated genes mapping near Lmr20, Lmr20a, Lmr20b and Lmr20c which mapped to D1Mit403 at 100.0 cM of CcS11/Dem in this study are: Fcer1a, Fc receptor, IgE, high affinity I, alpha polypeptide at 94.2 cM; Fcer1g, Fc receptor, IgE, high affinity I, gamma polypeptide at 93.3 cM; Fcgr2b, Fc receptor, IgG, low affinity IIb at 92.3 cM; Cluster of IFN activated genes: Ifi201,Ifi202a; Ifi203, and Ifi204 between 95.2-95.3 cM; and Tgfb2, transforming growth factor, beta 2 at 101.5 cM. [Table 9.] Possibly related QTL controlling other infections and co-localizing with the Lmr20 QTL are: Tir3c, trypanosome infection response 3c at 93.0 cM; Ssta2, susceptibility to Salmonella typhimurium antigens 2 at 95.8 cM; Bbaa12, B.burgdorferi-associated arthritis 12 at 96.0 cM; and, Berr1, berghei resistance locus 1 at 102.0 cM; [Table 10].
Lmr20c	Chr1, syntenic	Chr1:175468817-175468938	J:152405	Potential candidated genes mapping near Lmr20, Lmr20a, Lmr20b and Lmr20c which mapped to D1Mit403 at 100.0 cM of CcS11/Dem in this study are: Fcer1a, Fc receptor, IgE, high affinity I, alpha polypeptide at 94.2 cM; Fcer1g, Fc receptor, IgE, high affinity I, gamma polypeptide at 93.3 cM; Fcgr2b, Fc receptor, IgG, low affinity IIb at 92.3 cM; Cluster of IFN activated genes: Ifi201,Ifi202a; Ifi203, and Ifi204 between 95.2-95.3 cM; and Tgfb2, transforming growth factor, beta 2 at 101.5 cM. [Table 9.] Possibly related QTL controlling other infections and co-localizing with the Lmr20 QTL are: Tir3c, trypanosome infection response 3c at 93.0 cM; Ssta2, susceptibility to Salmonella typhimurium antigens 2 at 95.8 cM; Bbaa12, B.burgdorferi-associated arthritis 12 at 96.0 cM; and, Berr1, berghei resistance locus 1 at 102.0 cM; [Table 10].

*cM position of peak correlated region/marker

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