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Ifi204 Gene Detail
Summary
  • Symbol
    Ifi204
  • Name
    interferon activated gene 204
  • Synonyms
    p204
  • Feature Type
    protein coding gene
  • IDs
    MGI:96429
    NCBI Gene: 15951
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:173574859-173594509 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 80.63 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    246 from dbSNP Build 142
  • Strain Annotations
    13
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96429
 protein coding gene Chr1:173574859-173594606 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016814
 protein coding gene Chr1:179710652-179731156 (-)
A/J MGP_AJ_G0016793
 protein coding gene Chr1:172455321-172477004 (-)
AKR/J MGP_AKRJ_G0016759
 protein coding gene Chr1:177635294-177651367 (-)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0016577
 protein coding gene Chr1:178261947-178285109 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017214
 protein coding gene Chr1:185730024-185759522 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014922
 protein coding gene Chr1:164112345-164143944 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0016551
 protein coding gene Chr1:192489695-192518250 (-)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0016652
 protein coding gene Chr1:169499774-169517595 (-)
LP/J MGP_LPJ_G0016730
 protein coding gene Chr1:180790252-180966501 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016682
 protein coding gene Chr1:199594135-199850769 (-)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0015943
 protein coding gene Chr1:170565421-170789731 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0016218
 protein coding gene Chr1:177578986-177600273 (-)



Homology
more
  • Human Ortholog
    IFI16, interferon gamma inducible protein 16
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFI16, interferon gamma inducible protein 16
  • Synonyms
    IFNGIP1, PYHIN2
  • Links
    NCBI Gene ID: 3428
    neXtProt AC: NX_Q16666
    UniProt: Q16666

  • Chr Location
    1q23.1; chr1:158999968-159055155 (+)  GRCh38
  • Human Ortholog
    MNDA, myeloid cell nuclear differentiation antigen
  • Synonyms
    PYHIN3
  • Links
    NCBI Gene ID: 4332
    neXtProt AC: NX_P41218
    UniProt: P41218

  • Chr Location
    1q23.1; chr1:158831351-158849506 (+)  GRCh38
  • Human Ortholog
    PYHIN1, pyrin and HIN domain family member 1
  • Synonyms
    IFIX
  • Links
    NCBI Gene ID: 149628
    neXtProt AC: NX_Q6K0P9
    UniProt: Q6K0P9

  • Chr Location
    1q23.1; chr1:158930796-158990870 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show decreased susceptibility to LPS-induced shock, showing decreased secretion and serum levels of pro-inflammatory cytokines.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    7
  • cDNA Data
    22
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000073489 Ensembl Gene Model | MGI Sequence Detail 19651 C57BL/6J ±  kb
    transcript ENSMUST00000111214 Ensembl | MGI Sequence Detail 2296 Not Applicable  
    polypeptide ENSMUSP00000106845 Ensembl | MGI Sequence Detail 619 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 11
      cDNA 25
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11222
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 21
    • Earliest
      J:9942 Opdenakker G, et al., Interferons as gene activators: a cluster of six interferon-activatable genes is linked to the erythroid alpha-spectrin locus on murine chromosome 1. Virology. 1989 Aug;171(2):568-78
    • Latest
      J:354143 Moran EA, et al., IFI207, a young and fast-evolving protein, controls retroviral replication via the STING pathway. mBio. 2024 Jul 17;15(7):e0120924
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory