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Igf2 Gene Detail
Summary
  • Symbol
    Igf2
  • Name
    insulin-like growth factor 2
  • Synonyms
    Igf-2, Igf-II, M6pr, Mpr, Peg2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96434
    NCBI Gene: 16002
  • Alliance
    gene page
  • Transcription Start Sites
    58 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:142204503-142220553 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 87.99 cM
  • Mapping Data
    29 experiments
Strain
Comparison
more
  • SNPs within 2kb
    252 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    4
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96434
 protein coding gene Chr7:142204503-142220566 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033261
 protein coding gene Chr7:147915804-147934137 (-)
A/J MGP_AJ_G0033244
 protein coding gene Chr7:143645892-143662035 (-)
AKR/J MGP_AKRJ_G0033176
 protein coding gene Chr7:147675547-147691596 (-)
BALB/cJ MGP_BALBcJ_G0033245
 protein coding gene Chr7:143417465-143433412 (-)
C3H/HeJ MGP_C3HHeJ_G0032960
 protein coding gene Chr7:147436085-147454355 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033755
 protein coding gene Chr7:153262361-153282637 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030728
 protein coding gene Chr7:144854325-144870428 (-)
CAST/EiJ MGP_CASTEiJ_G0032283
 protein coding gene Chr7:139752723-139775983 (-)
CBA/J MGP_CBAJ_G0032931
 protein coding gene Chr7:158511697-158533256 (-)
DBA/2J MGP_DBA2J_G0033085
 protein coding gene Chr7:141596956-141614026 (-)
FVB/NJ MGP_FVBNJ_G0033034
 protein coding gene Chr7:141534396-141550882 (-)
LP/J MGP_LPJ_G0033178
 protein coding gene Chr7:149426487-149442449 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033068
 protein coding gene Chr7:159124753-159144024 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033774
 protein coding gene Chr7:146627176-146649889 (-)
PWK/PhJ MGP_PWKPhJ_G0031991
 protein coding gene Chr7:134926171-134943011 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031837
 protein coding gene Chr7:133425497-133441537 (-)
WSB/EiJ MGP_WSBEiJ_G0032395
 protein coding gene Chr7:147621277-147639202 (-)



Homology
more
  • Human Ortholog
    IGF2, insulin like growth factor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGF2, insulin like growth factor 2
  • Synonyms
    C11orf43, GRDF, IGF-II, PP9974, SRS3
  • Links
    NCBI Gene ID: 3481
    neXtProt AC: NX_P01344
    UniProt: P01344

  • Chr Location
    11p15.5; chr11:2129112-2158391 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Igf2 mouse models; 4 with human IGF2 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    66 phenotypes from 8 alleles in 15 genetic backgrounds
    68 phenotypes from multigenic genotypes
    119 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations that are paternally transmitted result in growth deficiency. Heterozygous mice inheriting a mutant allele from their mother appear to be phenotypically normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    72
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2177
  • Tissues
    430
  • cDNA Data
    381
  • Literature Summary
    255
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048583 Ensembl Gene Model | MGI Sequence Detail 16051 C57BL/6J ±  kb
    transcript ENSMUST00000121128 Ensembl | MGI Sequence Detail 4722 Not Applicable  
    polypeptide ENSMUSP00000114076 Ensembl | MGI Sequence Detail 191 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 512
      Genomic 42
      cDNA 395
      Primer pair 52
      Other 23

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11227, MGD-MRK-11230, MGI:2142106
    References
    more
    • Summaries
      All 579
      Developmental Gene Expression 255
      Diseases 2
      Gene Ontology 22
      Phenotypes 119
    • Earliest
      J:8474 Stempien MM, et al., Sequence of a placental cDNA encoding the mouse insulin-like growth factor II precursor. DNA. 1986 Oct;5(5):357-61
    • Latest
      J:357463 Flaherty SE 3rd, et al., SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic dysfunction. Elife. 2024 Jul 26;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory