Igh Complex/Cluster/Region Detail

Summary

• Symbol
  Igh
• Name
  immunoglobulin heavy chain complex

• Feature Type
  complex/cluster/region
  BioType Conflict
  
• IDs
  MGI:96442
  NCBI Gene: 111507

Location &
Maps

• Sequence Map
  Chr12:113222388-115973574 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 12, Syntenic
• Mapping Data
  26 experiments

Strain
Comparison

• SNPs within 2kb
  91840 from dbSNP Build 142
• PCR
  10
• RFLP
  4

Human Diseases

• Mutations/Alleles
  5 with disease annotations

• References
  5 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  77 phenotypes from 42 alleles in 32 genetic backgrounds
  118 phenotypes from multigenic genotypes
  511 phenotype references
  

• All Mutations and Alleles
  131
• Endonuclease-mediated
  7
• Targeted
  102
• Transgenic
  20
• Genomic Mutations
  11 involving Igh
• Find Mice (IMSR)
  44 strains or lines available

Mice homozygous for a knock-out allele exhibit abnormal B cell morphology and physiology.

Sequences &
Gene Models

• All Sequences
  2
• RefSeq
  1

• NCBI Gene
  111507

Representative Sequences			Length	Strain/Species
genomic	111507	NCBI Gene Model | MGI Sequence Detail	2751187	C57BL/6J

Molecular
Reagents

• All nucleic 11

  Genomic 2

  cDNA 2

  Primer pair 6

  Other 1

Other
Accession IDs

MGD-MRK-11239

References

• Summaries
  All 671

  Diseases 5

  Phenotypes 511
• Earliest
  J:284952 Bosma MJ, et al., Congenic mouse strains: the expression of a hidden immunoglobulin allotype in a congenic partner strain of BALB-c mice. J Exp Med. 1974;139(3):512-27
• Latest
  J:358428 Wang Y, et al., Progressive polyadenylation and m6A modification of Ighg1 mRNA maintain IgG1 antibody homeostasis in antibody-secreting cells. Immunity. 2024 Nov 12;57(11):2547-2564.e12