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Igha Gene Detail
Summary
  • Symbol
    Igha
  • Name
    immunoglobulin heavy constant alpha
  • Synonyms
    IgA, Igh-2
  • Feature Type
    gene segment
  • IDs
    MGI:96444
    NCBI Gene: 238447
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:113219824-113223856 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 62.09 cM
  • Mapping Data
    19 experiments
Strain
Comparison
more
  • SNPs within 2kb
    207 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96444
 gene segment Chr12:113218450-113223856 (-)
129S1/SvImJ MGP_129S1SvImJ_G0000003
 gene segment Chr12:115782840-115788231 (-)
A/J MGP_AJ_G0000003
 gene segment Chr12:111279872-111285263 (-)
AKR/J MGP_AKRJ_G0000003
 gene segment Chr12:114520743-114526145 (-)
BALB/cJ MGP_BALBcJ_G0000003
 gene segment Chr12:111746044-111751436 (-)
C3H/HeJ MGP_C3HHeJ_G0000003
 gene segment Chr12:115030068-115035461 (-)
C57BL/6NJ MGP_C57BL6NJ_G0000003
 gene segment Chr12:119304270-119309673 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0000003
 gene segment Chr12:107696457-107702027 (-)
CAST/EiJ MGP_CASTEiJ_G0000005
 gene segment Chr12:109895532-109900948 (-)
CBA/J MGP_CBAJ_G0000003
 gene segment Chr12:123884809-123890202 (-)
DBA/2J MGP_DBA2J_G0000003
 gene segment Chr12:110799844-110805269 (-)
FVB/NJ MGP_FVBNJ_G0000003
 gene segment Chr12:109628077-109633500 (-)
LP/J MGP_LPJ_G0000003
 gene segment Chr12:115594721-115600124 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0000003
 gene segment Chr12:126987799-126993202 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0000003
 gene segment Chr12:114033831-114039225 (-)
PWK/PhJ MGP_PWKPhJ_G0000003
 gene segment Chr12:105443000-105448421 (-)
SPRET/EiJ MGP_SPRETEiJ_G0000003
 gene segment Chr12:108225602-108231021 (-)
WSB/EiJ MGP_WSBEiJ_G0000003
 gene segment Chr12:114941158-114946578 (-)



Homology
more
  • Human Ortholog
    IGHA1, immunoglobulin heavy constant alpha 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGHA1, immunoglobulin heavy constant alpha 1
  • Synonyms
    IgA1
  • Links
    NCBI Gene ID: 3493
    UniProt: P01876

  • Chr Location
    14q32.33; chr14:105703995-105708665 (-)  GRCh38
  • Human Ortholog
    IGHA2, immunoglobulin heavy constant alpha 2 (A2m marker)
  • Synonyms
    A2M
  • Links
    NCBI Gene ID: 3494
    UniProt: P01877

  • Chr Location
    14q32.33; chr14:105583731-105588395 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have no detectable levels of IgA, decreased levels of IgG3, and increased levels of most other classes of immunoglobulins.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    5
  • cDNA Data
    2
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      30
    • RefSeq
      1
    • UniProt
      2
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 238447 NCBI Gene Model | MGI Sequence Detail 4033 C57BL/6J ±  kb
    transcript AK136471 GenBank | ENA | DDBJ | MGI Sequence Detail 2959 C57BL/6J  
    polypeptide A0A0A6YXW6 UniProt | EBI | MGI Sequence Detail 389 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 28
      cDNA 9
      Primer pair 1
      Other 1
    Other
    Accession IDs
    less
    MGD-MRK-11241
    References
    more
    • Summaries
      All 125
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 11
      Phenotypes 61
    • Earliest
      J:12170 Herzenberg LA, et al., Genetics of antibodies. Annu Rev Genet. 1968;2:209-44
    • Latest
      J:349515 Pecha B, et al., Identification of Intestinal Lamina Propria Plasma Cells by Surface Transmembrane Activator and CAML Interactor Expression. J Immunol. 2024 Mar 15;212(6):1022-1028
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory