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Ighg1 Gene Detail
Summary
  • Symbol
    Ighg1
  • Name
    immunoglobulin heavy constant gamma 1 (G1m marker)
  • Synonyms
    IgG1, Igh-4
  • Feature Type
    gene segment
  • IDs
    MGI:96446
    NCBI Gene: 16017
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:113290161-113294143 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 62.10 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96446
 gene segment Chr12:113288860-113294143 (-)
129S1/SvImJ MGP_129S1SvImJ_G0000007
 gene segment Chr12:115880566-115885851 (-)
A/J MGP_AJ_G0000007
 gene segment Chr12:111369341-111374626 (-)
AKR/J MGP_AKRJ_G0000006
 gene segment Chr12:114624615-114629901 (-)
BALB/cJ MGP_BALBcJ_G0000007
 gene segment Chr12:111825037-111830322 (-)
C3H/HeJ MGP_C3HHeJ_G0000007
 gene segment Chr12:115103379-115108666 (-)
C57BL/6NJ MGP_C57BL6NJ_G0000007
 gene segment Chr12:119381025-119386308 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0000006
 gene segment Chr12:107773590-107778924 (-)
CAST/EiJ MGP_CASTEiJ_G0000008
 gene segment Chr12:109996734-110002048 (-)
CBA/J MGP_CBAJ_G0000007
 gene segment Chr12:123982041-123987328 (-)
DBA/2J MGP_DBA2J_G0000007
 gene segment Chr12:110866638-110871925 (-)
FVB/NJ MGP_FVBNJ_G0000007
 gene segment Chr12:109700343-109705636 (-)
LP/J MGP_LPJ_G0000007
 gene segment Chr12:115681896-115687179 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0000006
 gene segment Chr12:127082402-127087685 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0000007
 gene segment Chr12:114114049-114119335 (-)
PWK/PhJ MGP_PWKPhJ_G0000007
 gene segment Chr12:105547812-105553097 (-)
SPRET/EiJ MGP_SPRETEiJ_G0000006
 gene segment Chr12:108303418-108308722 (-)
WSB/EiJ MGP_WSBEiJ_G0000007
 gene segment Chr12:115052065-115057345 (-)



Homology
more
  • Human Ortholog
    IGHG1, immunoglobulin heavy constant gamma 1 (G1m marker)
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGHG1, immunoglobulin heavy constant gamma 1 (G1m marker)
  • Links
    NCBI Gene ID: 3500
    UniProt: P01857

  • Chr Location
    14q32.33; chr14:105736343-105743071 (-)  GRCh38
  • Human Ortholog
    IGHG2, immunoglobulin heavy constant gamma 2 (G2m marker)
  • Links
    NCBI Gene ID: 3501
    UniProt: P01859

  • Chr Location
    14q32.33; chr14:105639559-105644790 (-)  GRCh38
  • Human Ortholog
    IGHG3, immunoglobulin heavy constant gamma 3 (G3m marker)
  • Synonyms
    IgG3
  • Links
    NCBI Gene ID: 3502
    UniProt: P01860

  • Chr Location
    14q32.33; chr14:105764503-105771405 (-)  GRCh38
  • Human Ortholog
    IGHG4, immunoglobulin heavy constant gamma 4 (G4m marker)
  • Links
    NCBI Gene ID: 3503
    UniProt: P01861

  • Chr Location
    14q32.33; chr14:105620506-105626066 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 7 alleles in 5 genetic backgrounds
    62 phenotypes from multigenic genotypes
    1 images
    129 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant mice are viable and fertile but show impaired primary and secondary Igh-4 immune responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    33
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      37
    • RefSeq
      1
    • UniProt
      3
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16017 NCBI Gene Model | MGI Sequence Detail 3983 C57BL/6J ±  kb
    transcript AK156019 GenBank | ENA | DDBJ | MGI Sequence Detail 1565 NOD  
    polypeptide P01869 UniProt | EBI | MGI Sequence Detail 393 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR050380 Immune Recognition and Response Modulators
      IPR003597 Immunoglobulin C1-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
    • GlyGen
      P01869 2 sites, 8 N-linked glycans (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 20
      cDNA 12
      Other 2

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-11243
    References
    more
    • Summaries
      All 217
      Developmental Gene Expression 1
      Diseases 3
      Gene Ontology 33
      Phenotypes 129
    • Earliest
      J:5041 Minna JD, et al., Identification of a gene locus for gamma-G-1 immunoglobulin H chains and its linkage to the H chain chromosome region in the mouse. Proc Natl Acad Sci U S A. 1967 Jul;58(1):188-94
    • Latest
      J:350805 Zhang L, et al., Regulation of BCR-mediated Ca(2+) mobilization by MIZ1-TMBIM4 safeguards IgG1(+) GC B cell-positive selection. Sci Immunol. 2024 Apr 5;9(94):eadk0092
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory