Igkc MGI Mouse Gene Detail - MGI:96495 - immunoglobulin kappa constant

Symbol

Igkc
Name

immunoglobulin kappa constant

Feature Type

gene segment
IDs

MGI:96495
NCBI Gene: 16071
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr6:70703419-70703738 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 32.04 cM, cytoband C
Mapping Data

17 experiments

SNPs within 2kb

80 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96495	gene segment	Chr6:70703419-70703950 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0000015	gene segment	Chr6:71140578-71141109 (+)
A/J	MGP_AJ_G0000015	gene segment	Chr6:68431659-68432190 (+)
AKR/J	MGP_AKRJ_G0000014	gene segment	Chr6:70402353-70402884 (+)
BALB/cJ	MGP_BALBcJ_G0000015	gene segment	Chr6:68457108-68457639 (+)
C3H/HeJ	MGP_C3HHeJ_G0000015	gene segment	Chr6:113864013-113864544 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0000015	gene segment	Chr6:73027106-73027637 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0000012	gene segment	Chr6:67619625-67620171 (+)
CAST/EiJ	MGP_CASTEiJ_G0000013	gene segment	Chr6:70238330-70238861 (+)
CBA/J	MGP_CBAJ_G0000015	gene segment	Chr6:75894752-75895283 (+)
DBA/2J	MGP_DBA2J_G0000015	gene segment	Chr6:67807249-67807780 (+)
FVB/NJ	MGP_FVBNJ_G0000015	gene segment	Chr6:67174243-67174774 (+)
LP/J	MGP_LPJ_G0000015	gene segment	Chr6:71080242-71080773 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0000014	gene segment	Chr6:79453644-79454175 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0000015	gene segment	Chr6:70225927-70226458 (+)
PWK/PhJ	MGP_PWKPhJ_G0000014	gene segment	Chr6:66663704-66664235 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0000012	gene segment	Chr6:68954243-68954771 (+)
WSB/EiJ	MGP_WSBEiJ_G0000015	gene segment	Chr6:70564411-70564942 (+)

Human Ortholog

IGKC, immunoglobulin kappa constant

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IGKC, immunoglobulin kappa constant
Synonyms

HCAK1, IGKCD, Km
Links

HGNC:5716

NCBI Gene ID: 3514

UniProt: P01834
Chr Location

2p11.2; chr2:88857161-88857683 (-) GRCh38

MGI Vertebrate Homology

Igkc stringent orthology
1 human;1 mouse;2 rat;3 zebrafish
HCOP

vertebrate homology predictions: IGKC
Gene Tree

Igkc

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Phenotype Summary

13 phenotypes from 3 alleles in 3 genetic backgrounds
25 phenotypes from multigenic genotypes
49 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Targeted

6
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene prevents the expression of rearranged kappa genes, leading to exclusive production of lambda chain-expressing B cells and alterations in immunization titers, germinal center development, and somatic hypermutation.

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All GO Annotations

4
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

764
Tissues

48
cDNA Data

3
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

34
RefSeq

1
UniProt

4

Ensembl

ENSMUSG00000076609 (Evidence)
NCBI Gene

16071

			Length	Strain/Species	Flank
genomic	16071	NCBI Gene Model \| MGI Sequence Detail	320	C57BL/6J	± kb
transcript	BC110685	GenBank \| ENA \| DDBJ \| MGI Sequence Detail	1017	CZECHII
polypeptide	P01837	UniProt \| EBI \| MGI Sequence Detail	107	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008966 immunoglobulin kappa constant

(term hierarchy)
PDB

1CBV, 1CGS, 1F3D, 1LO0, 1M71, 1M7D, 1M7I, 1MNU, 1MPA, 1NBV, 1PLG, 1PZ5, 1QFU, 1T2Q, 1YNK, 1YNL, 1ZEA, 2A1W, 2CGR, 2DQT, 2DQU, 2DTM, 2IPT, 2IPU, 2IQ9, 2IQA, 2MPA, 2OJZ, 2OK0, 2R0W, 2R0Z, 3BAE, 3BKC, 3BKJ, 3BKM, 3BQU, 3EYS, 3EYU, 3UO1, 3UYR, 3V4U, 3V52, 3WE6, 4F37, 4HDI, 4OCX, 4OCY, 4P3D, 4Q0X, 4TPR, 4TQE, 4ZXB, 6PXR, 7A6C
InterPro Domains

IPR003597 Immunoglobulin C1-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003006 Immunoglobulin/major histocompatibility complex, conserved site

IPR003599 Immunoglobulin subtype

IPR050150 Immunoglobulin Variable Light Chain

IPR013106 Immunoglobulin V-set domain

IPR050160 Major Histocompatibility Complex/Immunoglobulin
GlyGen

P01837 1 site, 1 O-linked glycan (1 site)

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All nucleic 99

Genomic 61

cDNA 32

Primer pair 3

Other 3

Microarray probesets 1

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MGD-MRK-11293

Summaries

All 123

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 49
Earliest

J:6069 Seidman JG, et al., The arrangement and rearrangement of antibody genes. Nature. 1978 Dec 21-28;276(5690):790-5
Latest

J:261505 Clark AG, et al., A murine Ig light chain transgene reveals IGKV3 gene contributions to anti-collagen types IV and II specificities. Mol Immunol. 2017 Nov;91:49-56

TSS for Igkc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56956	Chr6:70702792-70702817 (+)	-614 bp
Tssr56957	Chr6:70703414-70703456 (+)	16 bp
Tssr56958	Chr6:70703461-70703472 (+)	48 bp
Tssr56959	Chr6:70703479-70703490 (+)	66 bp
Tssr56960	Chr6:70703502-70703505 (+)	85 bp
Tssr56961	Chr6:70703516-70703521 (+)	100 bp
Tssr56962	Chr6:70703524-70703533 (+)	110 bp
Tssr56963	Chr6:70703573-70703580 (+)	158 bp
Tssr56964	Chr6:70703588-70703591 (+)	171 bp
Tssr56965	Chr6:70703594-70703603 (+)	180 bp
Tssr56966	Chr6:70703605-70703611 (+)	189 bp
Tssr56967	Chr6:70703620-70703631 (+)	207 bp
Tssr56968	Chr6:70703644-70703661 (+)	234 bp
Tssr56969	Chr6:70703680-70703685 (+)	264 bp
Tssr56970	Chr6:70703693-70703704 (+)	280 bp
Tssr56971	Chr6:70703713-70703716 (+)	296 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24