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Rbpj Gene Detail
Summary
  • Symbol
    Rbpj
  • Name
    recombination signal binding protein for immunoglobulin kappa J region
  • Synonyms
    CBF1, Igkjrb, Igkrsbp, RBPjk, RBP-J kappa, Rbpsuh
  • Feature Type
    protein coding gene
  • IDs
    MGI:96522
    NCBI Gene: 19664
  • Alliance
    gene page
  • Transcription Start Sites
    39 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:53713121-53814787 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 29.37 cM, cytoband C1-C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2309 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96522
 protein coding gene Chr5:53623494-53814787 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029554
 protein coding gene Chr5:52519949-52725471 (+)
A/J MGP_AJ_G0029522
 protein coding gene Chr5:50658065-50864071 (+)
AKR/J MGP_AKRJ_G0029470
 protein coding gene Chr5:52415639-52613335 (+)
BALB/cJ MGP_BALBcJ_G0029531
 protein coding gene Chr5:51152490-51347197 (+)
C3H/HeJ MGP_C3HHeJ_G0029254
 protein coding gene Chr5:52547458-52754426 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029985
 protein coding gene Chr5:54683029-54885003 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027225
 protein coding gene Chr5:47409715-47595291 (+)
CAST/EiJ MGP_CASTEiJ_G0028662
 protein coding gene Chr5:51560651-51766187 (+)
CBA/J MGP_CBAJ_G0029223
 protein coding gene Chr5:56381168-56619132 (+)
DBA/2J MGP_DBA2J_G0029369
 protein coding gene Chr5:50730321-50923131 (+)
FVB/NJ MGP_FVBNJ_G0029329
 protein coding gene Chr5:50060840-50251660 (+)
LP/J MGP_LPJ_G0029454
 protein coding gene Chr5:52983907-53174735 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029357
 protein coding gene Chr5:57425476-57630477 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030018
 protein coding gene Chr5:51896207-52106449 (+)
PWK/PhJ MGP_PWKPhJ_G0028386
 protein coding gene Chr5:49787019-49977851 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028220
 protein coding gene Chr5:51338220-51540891 (+)
WSB/EiJ MGP_WSBEiJ_G0028743
 protein coding gene Chr5:51961973-52160904 (+)



Homology
more
  • Human Ortholog
    RBPJ, recombination signal binding protein for immunoglobulin kappa J region
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RBPJ, recombination signal binding protein for immunoglobulin kappa J region
  • Synonyms
    AOS3, CBF-1, CBF1, csl, IGKJRB, IGKJRB1, KBF2, RBP-J, RBP-JK, RBPJK, RBP-J kappa, RBPSUH, SUH
  • Links
    NCBI Gene ID: 3516
    neXtProt AC: NX_Q06330
    UniProt: Q06330

  • Chr Location
    4p15.2; chr4:26105449-26435131 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rbpj mouse models; 2 with human RBPJ associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    122 phenotypes from 6 alleles in 18 genetic backgrounds
    23 phenotypes from multigenic genotypes
    2 images
    429 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit complete prenatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    139
  • GO References
    49
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    889
  • Tissues
    80
  • cDNA Data
    25
  • Literature Summary
    87
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19664 NCBI Gene Model | MGI Sequence Detail 101667 C57BL/6J ±  kb
    transcript NM_001277116 RefSeq | MGI Sequence Detail 5590 ZRU/MplStud  
    polypeptide P31266 UniProt | EBI | MGI Sequence Detail 526 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 2
      cDNA 26
      Primer pair 9
      Other 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-11327, MGI:2140979
    References
    more
    • Summaries
      All 570
      Developmental Gene Expression 87
      Diseases 1
      Gene Ontology 49
      Phenotypes 429
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:358439 Sisl D, et al., Modulation of Notch signaling pathway in activated hepatic stellate cells does not ameliorate the outcome of liver fibrosis in carbon tetrachloride and DDC-feeding models. Front Pharmacol. 2024;15:1440236
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory