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Il10ra Gene Detail
Summary
  • Symbol
    Il10ra
  • Name
    interleukin 10 receptor, alpha
  • Synonyms
    CDw210, Il10r, mIL-10R
  • Feature Type
    protein coding gene
  • IDs
    MGI:96538
    NCBI Gene: 16154
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:45165135-45180447 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    552 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96538
 protein coding gene Chr9:45165135-45180447 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034735
 protein coding gene Chr9:43802289-43820826 (-)
A/J MGP_AJ_G0034716
 protein coding gene Chr9:42582212-42597510 (-)
AKR/J MGP_AKRJ_G0034643
 protein coding gene Chr9:43456112-43471145 (-)
BALB/cJ MGP_BALBcJ_G0034707
 protein coding gene Chr9:42312977-42328005 (-)
C3H/HeJ MGP_C3HHeJ_G0034418
 protein coding gene Chr9:43917089-43932791 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035228
 protein coding gene Chr9:45083483-45101240 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032142
 protein coding gene Chr9:42133627-42148632 (-)
CAST/EiJ MGP_CASTEiJ_G0033740
 protein coding gene Chr9:43774948-43791179 (-)
CBA/J MGP_CBAJ_G0034390
 protein coding gene Chr9:46734397-46752062 (-)
DBA/2J MGP_DBA2J_G0034549
 protein coding gene Chr9:42468021-42483200 (-)
FVB/NJ MGP_FVBNJ_G0034490
 protein coding gene Chr9:41727547-41743495 (-)
LP/J MGP_LPJ_G0034630
 protein coding gene Chr9:44110923-44129474 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034534
 protein coding gene Chr9:48553047-48568075 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035249
 protein coding gene Chr9:43376845-43393145 (-)
PWK/PhJ MGP_PWKPhJ_G0033445
 protein coding gene Chr9:42356313-42373096 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033281
 protein coding gene Chr9:43678632-43695810 (-)
WSB/EiJ MGP_WSBEiJ_G0033853
 protein coding gene Chr9:43408263-43424825 (-)



Homology
more
  • Human Ortholog
    IL10RA, interleukin 10 receptor subunit alpha
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL10RA, interleukin 10 receptor subunit alpha
  • Synonyms
    CD210, CD210a, CDW210A, HIL-10R, IL10R, IL-10R1
  • Links
    NCBI Gene ID: 3587
    neXtProt AC: NX_Q13651
    UniProt: Q13651

  • Chr Location
    11q23.3; chr11:117986370-118003037 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IL10RA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 6 alleles in 7 genetic backgrounds
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-generated null allele suffer from a severe inflammatory bowel syndrome. Mice heterozygote for an NZW variant allele have high sera levels of anti-chromatin antibodies. Mice homozygous for a knock-out allele exhibit increased susceptibility to induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16154 NCBI Gene Model | MGI Sequence Detail 15313 C57BL/6J ±  kb
    transcript NM_008348 RefSeq | MGI Sequence Detail 3509 ZRU/MplStud  
    polypeptide Q61727 UniProt | EBI | MGI Sequence Detail 575 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 21
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11362, MGI:2143329
    References
    more
    • Summaries
      All 105
      Gene Ontology 4
      Phenotypes 52
    • Earliest
      J:16339 Ho AS, et al., A receptor for interleukin 10 is related to interferon receptors. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11267-71
    • Latest
      J:348270 Horn KJ, et al., Neutrophil responsiveness to IL-10 impairs clearance of Streptococcus pneumoniae from the lungs. J Leukoc Biol. 2024 Jan 5;115(1):4-15
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory