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Il2 Gene Detail
Summary
  • Symbol
    Il2
  • Name
    interleukin 2
  • Synonyms
    IL-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96548
    NCBI Gene: 16183
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr3:37174862-37180103 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 18.30 cM, cytoband B-C
  • Mapping Data
    35 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    17
  • PCR
    7
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96548
 protein coding gene Chr3:37174672-37180108 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027166
 protein coding gene Chr3:34965375-34970738 (-)
A/J MGP_AJ_G0027126
 protein coding gene Chr3:34270359-34275797 (-)
AKR/J MGP_AKRJ_G0027095
 protein coding gene Chr3:34906358-34913994 (-)
BALB/cJ MGP_BALBcJ_G0027138
 protein coding gene Chr3:34020817-34026126 (-)
C3H/HeJ MGP_C3HHeJ_G0026881
 protein coding gene Chr3:34964408-34971450 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027584
 protein coding gene Chr3:36596469-36603033 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024945
 protein coding gene Chr3:31949970-31955112 (-)
CAST/EiJ MGP_CASTEiJ_G0026334
 protein coding gene Chr3:34829960-34835250 (-)
CBA/J MGP_CBAJ_G0026858
 protein coding gene Chr3:37582016-37587469 (-)
DBA/2J MGP_DBA2J_G0026992
 protein coding gene Chr3:33708216-33713659 (-)
FVB/NJ MGP_FVBNJ_G0026960
 protein coding gene Chr3:33151123-33156559 (-)
LP/J MGP_LPJ_G0027104
 protein coding gene Chr3:35739981-35746725 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0027643
 protein coding gene Chr3:34759382-34766695 (-)
PWK/PhJ MGP_PWKPhJ_G0026067
 protein coding gene Chr3:33394689-33400140 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025879
 protein coding gene Chr3:34125007-34131586 (-)
WSB/EiJ MGP_WSBEiJ_G0026408
 protein coding gene Chr3:34783833-34790884 (-)



Homology
more
  • Human Ortholog
    IL2, interleukin 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL2, interleukin 2
  • Synonyms
    IL-2, lymphokine, TCGF
  • Links
    NCBI Gene ID: 3558
    neXtProt AC: NX_P60568
    UniProt: P60568

  • Chr Location
    4q27; chr4:122451470-122456725 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Il2 mouse models; 32 with human IL2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 1 model
      
IDs
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    98 phenotypes from 4 alleles in 11 genetic backgrounds
    34 phenotypes from multigenic genotypes
    228 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants develop adult onset autoimmune disease, with 50% mortality by 9 weeks due to hemolytic anemia. Survivors develop inflammatory bowl disease/colitis. Immune system dysregulation and CD4+ T-cell overproduction may be responsible.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    19
  • cDNA Data
    15
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16183 NCBI Gene Model | MGI Sequence Detail 5242 C57BL/6J ±  kb
    transcript NM_008366 RefSeq | MGI Sequence Detail 955 ZRU/MplStud  
    polypeptide P04351 UniProt | EBI | MGI Sequence Detail 169 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 12
      cDNA 15
      Primer pair 10
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11353, MGD-MRK-11374
    References
    more
    • Summaries
      All 598
      Developmental Gene Expression 11
      Diseases 4
      Gene Ontology 31
      Phenotypes 228
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:355474 Mitchell JS, et al., CD4(+) T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes. Immunity. 2024 Oct 8;57(10):2399-2415.e8
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory