Il9 MGI Mouse Gene Detail - MGI:96563

Symbol

Il9
Name

interleukin 9
Synonyms

Il-9, P40

Feature Type

protein coding gene
IDs

MGI:96563
NCBI Gene: 16198
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr13:56627090-56630059 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 30.06 cM
Mapping Data

48 experiments

SNPs within 2kb

205 from dbSNP Build 142
Strain Annotations

18
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96563	protein coding gene	Chr13:56627090-56630070 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020619	protein coding gene	Chr13:56030840-56033803 (-)
A/J	MGP_AJ_G0020573	protein coding gene	Chr13:53950472-53953445 (-)
AKR/J	MGP_AKRJ_G0020551	protein coding gene	Chr13:55546722-55549691 (-)
BALB/cJ	MGP_BALBcJ_G0020569	protein coding gene	Chr13:54182012-54184985 (-)
C3H/HeJ	MGP_C3HHeJ_G0020368	protein coding gene	Chr13:55354321-55357294 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021003	protein coding gene	Chr13:57724358-57727327 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018585	protein coding gene	Chr13:51886447-51889410 (-)
CAST/EiJ	MGP_CASTEiJ_G0019882	protein coding gene	Chr13:55477419-55480378 (-)
CBA/J	MGP_CBAJ_G0020328	protein coding gene	Chr13:59940436-59943409 (-)
DBA/2J	MGP_DBA2J_G0020451	protein coding gene	Chr13:53495064-53498027 (-)
FVB/NJ	MGP_FVBNJ_G0020430	protein coding gene	Chr13:52967750-52970719 (-)
LP/J	MGP_LPJ_G0020527	protein coding gene	Chr13:56288773-56291746 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020459	protein coding gene	Chr13:59342728-59345691 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021046	protein coding gene	Chr13:55133702-55136671 (-)
PWK/PhJ	MGP_PWKPhJ_G0019638	protein coding gene	Chr13:53530289-53533260 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019465	protein coding gene	Chr13:54082123-54085077 (-)
WSB/EiJ	MGP_WSBEiJ_G0019944	protein coding gene	Chr13:55500618-55503581 (-)

Human Ortholog

IL9, interleukin 9

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL9, interleukin 9
Synonyms

HP40, IL-9, P40
Links

HGNC:6029

NCBI Gene ID: 3578

neXtProt AC: NX_P15248

UniProt: P15248
Chr Location

5q31.1; chr5:135892246-135895841 (-) GRCh38

MGI Vertebrate Homology

Il9 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: IL9
Gene Tree

Il9

Diseases

2 with human IL9 associations

				Human Disease	Mouse Models
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				respiratory syncytial virus infectious disease IDs respiratory syncytial virus infectious disease DOID:1273 MESH:D018357 NCI:C3354 UMLS_CUI:C0035235

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

23 phenotypes from 5 alleles in 7 genetic backgrounds
12 phenotypes from multigenic genotypes
64 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

1
Endonuclease-mediated

8
Targeted

5
Transgenic

4
Genomic Mutations

1 involving Il9
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are viable and show no overt phenotype, however when challenged, aspects of the inflammatory response are shown to be impaired.

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All GO Annotations

22
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

733
Tissues

21
cDNA Data

1
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

27
RefSeq

2
UniProt

1
CCDS

CCDS26562.1

Ensembl

ENSMUSG00000021538 (Evidence)
NCBI Gene

16198

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021538	Ensembl Gene Model \| MGI Sequence Detail	2970	C57BL/6J	± kb
transcript	ENSMUST00000022019	Ensembl \| MGI Sequence Detail	536	Not Applicable
polypeptide	ENSMUSP00000022019	Ensembl \| MGI Sequence Detail	144	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001396 interleukin-9

(term hierarchy)
PDB

7OX4, 7XCB
InterPro Domains

IPR018049 Interleukin-7/Interleukin-9, conserved site

IPR020447 Interleukin-9
GlyGen

P15247 4 sites

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All nucleic 3

Genomic 1

cDNA 1

Primer pair 1

Microarray probesets 3

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MGD-MRK-11359, MGD-MRK-11397

Summaries

All 174

Developmental Gene Expression 3

Gene Ontology 10

Phenotypes 64
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:358507 Schmitt P, et al., TL1A is an epithelial alarmin that cooperates with IL-33 for initiation of allergic airway inflammation. J Exp Med. 2024 Jun 3;221(6)

TSS for Il9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122784	Chr13:56630068-56630071 (-)	-11 bp
Tssr122783	Chr13:56629966-56630010 (-)	71 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24