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Inhba Gene Detail
Summary
  • Symbol
    Inhba
  • Name
    inhibin beta-A
  • Synonyms
    activin beta-A
  • Feature Type
    protein coding gene
  • IDs
    MGI:96570
    NCBI Gene: 16323
  • Alliance
    gene page
  • Transcription Start Sites
    56 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:16186436-16206206 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 5.85 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    346 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96570
 protein coding gene Chr13:16178841-16206206 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020248
 protein coding gene Chr13:12992602-13007945 (+)
A/J MGP_AJ_G0020206
 protein coding gene Chr13:12894954-12913791 (+)
AKR/J MGP_AKRJ_G0020180
 protein coding gene Chr13:13093335-13110102 (+)
BALB/cJ MGP_BALBcJ_G0020192
 protein coding gene Chr13:12836177-12851680 (+)
C3H/HeJ MGP_C3HHeJ_G0019996
 protein coding gene Chr13:13157464-13172350 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020636
 protein coding gene Chr13:13705946-13724162 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018242
 protein coding gene Chr13:11509654-11524985 (+)
CAST/EiJ MGP_CASTEiJ_G0019529
 protein coding gene Chr13:12872508-12887595 (+)
CBA/J MGP_CBAJ_G0019960
 protein coding gene Chr13:14092929-14110461 (+)
DBA/2J MGP_DBA2J_G0020079
 protein coding gene Chr13:12505306-12520209 (+)
FVB/NJ MGP_FVBNJ_G0020060
 protein coding gene Chr13:12263352-12279768 (+)
LP/J MGP_LPJ_G0020149
 protein coding gene Chr13:13250523-13267865 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020097
 protein coding gene Chr13:14342809-14360351 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020663
 protein coding gene Chr13:12888974-12907324 (+)
PWK/PhJ MGP_PWKPhJ_G0019293
 protein coding gene Chr13:12598996-12614564 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019100
 protein coding gene Chr13:11990516-12009077 (+)
WSB/EiJ MGP_WSBEiJ_G0019591
 protein coding gene Chr13:12877837-12895069 (+)



Homology
more
  • Human Ortholog
    INHBA, inhibin subunit beta A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INHBA, inhibin subunit beta A
  • Synonyms
    EDF, FRP
  • Links
    NCBI Gene ID: 3624
    neXtProt AC: NX_P08476
    UniProt: P08476

  • Chr Location
    7p14.1; chr7:41667168-41705834 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 5 genetic backgrounds
    41 phenotypes from multigenic genotypes
    1 images
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation lack vibrissae and lower incisors, have defects in their secondary palates, and die shortly after birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    114
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1256
  • Tissues
    229
  • cDNA Data
    19
  • Literature Summary
    93
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041324 Ensembl Gene Model | MGI Sequence Detail 19771 C57BL/6J ±  kb
    transcript ENSMUST00000042603 Ensembl | MGI Sequence Detail 6390 Not Applicable  
    polypeptide ENSMUSP00000047894 Ensembl | MGI Sequence Detail 424 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 30
      Primer pair 12
      Other 10

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11407
    References
    more
    • Summaries
      All 201
      Developmental Gene Expression 93
      Gene Ontology 17
      Phenotypes 37
    • Earliest
      J:8262 Mason AJ, et al., Structure of two human ovarian inhibins. Biochem Biophys Res Commun. 1986 Mar 28;135(3):957-64
    • Latest
      J:357285 Koo HY, et al., Analysis of Meis2 knockout mice reveals Sonic hedgehog-mediated patterning of the cochlear duct. Dev Dyn. 2024 Oct 1;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory