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Ins2 Gene Detail
Summary
  • Symbol
    Ins2
  • Name
    insulin II
  • Synonyms
    Ins-2, InsII, Mody, Mody4
  • Feature Type
    protein coding gene
  • IDs
    MGI:96573
    NCBI Gene: 16334
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:142232393-142233463 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 88.00 cM
  • Mapping Data
    34 experiments
Strain
Comparison
more
  • SNPs within 2kb
    86 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    3
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96573
 protein coding gene Chr7:142232393-142297118 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033262
 protein coding gene Chr7:147947054-147968911 (-)
A/J MGP_AJ_G0033245
 protein coding gene Chr7:143675309-143696169 (-)
AKR/J MGP_AKRJ_G0033177
 protein coding gene Chr7:147714942-147735801 (-)
BALB/cJ MGP_BALBcJ_G0033246
 protein coding gene Chr7:143449078-143469844 (-)
C3H/HeJ MGP_C3HHeJ_G0032961
 protein coding gene Chr7:147468531-147489385 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033756
 protein coding gene Chr7:153297876-153318736 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030729
 protein coding gene Chr7:144882568-144906590 (-)
CAST/EiJ MGP_CASTEiJ_G0032284
 protein coding gene Chr7:139789113-139810332 (-)
CBA/J MGP_CBAJ_G0032932
 protein coding gene Chr7:158545620-158566454 (-)
DBA/2J MGP_DBA2J_G0033086
 protein coding gene Chr7:141626133-141646991 (-)
FVB/NJ MGP_FVBNJ_G0033035
 protein coding gene Chr7:141562748-141583590 (-)
LP/J MGP_LPJ_G0033179
 protein coding gene Chr7:149455414-149478621 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033069
 protein coding gene Chr7:159158786-159179644 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033775
 protein coding gene Chr7:146666411-146687269 (-)
PWK/PhJ MGP_PWKPhJ_G0031992
 protein coding gene Chr7:134955376-134977340 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031838
 protein coding gene Chr7:133457972-133480044 (-)
WSB/EiJ MGP_WSBEiJ_G0032396
 protein coding gene Chr7:147651750-147672630 (-)



Homology
more
  • Human Ortholog
    INS, insulin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INS, insulin
  • Synonyms
    IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10, PNDM4
  • Links
    NCBI Gene ID: 3630
    neXtProt AC: NX_P01308
    UniProt: P01308

  • Chr Location
    11p15.5; chr11:2159779-2161221 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with Ins2 mouse models; 10 with human INS associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 6 models
IDs
 View 1 model
      
IDs
 View 3 models
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    13 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    91 phenotypes from 8 alleles in 12 genetic backgrounds
    90 phenotypes from multigenic genotypes
    4 images
    478 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for spontaneous or knock-out alleles exhibit increased mortality, abnormal growth, abnormal glucose homeostasis, impaired pancreatic function, and phenotypes associated with type 2 diabetes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    91
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1461
  • Tissues
    162
  • cDNA Data
    145
  • Literature Summary
    518
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16334 NCBI Gene Model | MGI Sequence Detail 1071 C57BL/6J ±  kb
    transcript NM_001185084 RefSeq | MGI Sequence Detail 587 ZRU/MplStud  
    polypeptide P01326 UniProt | EBI | MGI Sequence Detail 110 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 208
      Genomic 30
      cDNA 146
      Primer pair 26
      Other 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11411, MGD-MRK-11414, MGD-MRK-39550, MGI:109551, MGI:2141856
    References
    more
    • Summaries
      All 1112
      Developmental Gene Expression 518
      Diseases 13
      Gene Ontology 27
      Phenotypes 478
    • Earliest
      J:6658 Goldfeld AE, et al., Genetic control of insulin receptors. Proc Natl Acad Sci U S A. 1981 Oct;78(10):6359-61
    • Latest
      J:358643 Stickel KC, et al., Mechanisms of spinophilin-dependent pancreas dysregulation in obesity. Am J Physiol Endocrinol Metab. 2024 Aug 1;327(2):E155-E171
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory