Ipp MGI Mouse Gene Detail - MGI:96581 - IAP promoted placental gene

Symbol

Ipp
Name

IAP promoted placental gene
Synonyms

D4Jhu8, Mipp

Feature Type

protein coding gene
IDs

MGI:96581
NCBI Gene: 16351
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr4:116364746-116395440 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 53.20 cM
Mapping Data

3 experiments

SNPs within 2kb

756 from dbSNP Build 142
Strain Annotations

18
RFLP

8

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96581	protein coding gene	Chr4:116364710-116400607 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028625	protein coding gene	Chr4:117399128-117436734 (+)
A/J	MGP_AJ_G0028586	protein coding gene	Chr4:112910525-112942576 (+)
AKR/J	MGP_AKRJ_G0028536	protein coding gene	Chr4:115339271-115372220 (+)
BALB/cJ	MGP_BALBcJ_G0028607	protein coding gene	Chr4:113536727-113567502 (+)
C3H/HeJ	MGP_C3HHeJ_G0028321	protein coding gene	Chr4:116910004-116941931 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029048	protein coding gene	Chr4:121947178-121986709 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026332	protein coding gene	Chr4:106949302-106981695 (+)
CAST/EiJ	MGP_CASTEiJ_G0027755	protein coding gene	Chr4:114139895-114175675 (+)
CBA/J	MGP_CBAJ_G0028288	protein coding gene	Chr4:125249047-125292347 (+)
DBA/2J	MGP_DBA2J_G0028436	protein coding gene	Chr4:113542839-113574031 (+)
FVB/NJ	MGP_FVBNJ_G0028404	protein coding gene	Chr4:112041908-112075316 (+)
LP/J	MGP_LPJ_G0028538	protein coding gene	Chr4:117616234-117650572 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028431	protein coding gene	Chr4:130246449-130281608 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029085	protein coding gene	Chr4:116493050-116532208 (+)
PWK/PhJ	MGP_PWKPhJ_G0027481	protein coding gene	Chr4:110319811-110353135 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027304	protein coding gene	Chr4:112765260-112802090 (+)
WSB/EiJ	MGP_WSBEiJ_G0027834	protein coding gene	Chr4:116371270-116403814 (+)

Human Ortholog

IPP, intracisternal A particle-promoted polypeptide

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IPP, intracisternal A particle-promoted polypeptide
Synonyms

KLHL27
Links

HGNC:6108

NCBI Gene ID: 3652

neXtProt AC: NX_Q9Y573

UniProt: Q9Y573
Chr Location

1p34.1; chr1:45694324-45750653 (-) GRCh38

MGI Vertebrate Homology

Ipp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IPP
Protein SuperFamily

Kelch-like_protein_gigaxonin
Gene Tree

Ipp

less

Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

14
Radiation induced

1
Targeted

5
Genomic Mutations

4 involving Ipp
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

7
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

760
Tissues

46
cDNA Data

14
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ipp

less

All Sequences

47
RefSeq

14
UniProt

2
CCDS

CCDS38851.1

Ensembl

ENSMUSG00000028696 (Evidence)
NCBI Gene

16351

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028696	Ensembl Gene Model \| MGI Sequence Detail	30695	C57BL/6J	± kb
transcript	ENSMUST00000106479	Ensembl \| MGI Sequence Detail	2118	Not Applicable
polypeptide	ENSMUSP00000102088	Ensembl \| MGI Sequence Detail	584	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000009092 actin-binding protein IPP

(term hierarchy)
InterPro Domains

IPR047067 Actin-binding protein IPP, BACK domain

IPR030104 Actin-binding protein IPP, BTB/POZ domain

IPR011705 BTB/Kelch-associated

IPR017096 BTB-kelch protein

IPR000210 BTB/POZ domain

IPR006652 Kelch repeat type 1

IPR015915 Kelch-type beta propeller

IPR011333 SKP1/BTB/POZ domain superfamily

less

All nucleic 17

Genomic 3

cDNA 14

Microarray probesets 4

less

MGD-MRK-11445, MGD-MRK-12244, MGD-MRK-6591, MGI:92709

Summaries

All 42

Developmental Gene Expression 3

Gene Ontology 3

Phenotypes 16
Earliest

J:11287 Mold DE, et al., Cell lineage-specific expression of the MIPP gene. Biochem Biophys Res Commun. 1991 Jun 28;177(3):1062-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ipp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr38517	Chr4:116364781-116364820 (+)	55 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24