Ir5 Gene Detail

Summary

• Symbol
  Ir5
• Name
  immune response 5
• Synonyms
  Ir-5

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:96587
  NCBI Gene: 109699
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 17, Syntenic

Mutations,
Alleles, and
Phenotypes

This locus controls, in part, immune response to Thy-1.1 antigen of AKR thymocytes. The response also is controlled by loci in the Ir1 region of H2. The dominant a allele (high response) is seen in DBA/2, CBA, C3H and C57BR; the b allele (low response) is seen in C57BL/6 and C57BL/10.

Sequences &
Gene Models

• NCBI Gene
  109699

Other
Accession IDs

MGD-MRK-11451, MGD-MRK-11459

References

• Summaries
  All 5
• Earliest
  J:5487 Zaleski M, et al., Immune response of mice to Thy-1. 1 antigen: genetic control by alleles at the Ir-5 locus loosely linked to the H-2 complex. J Immunol. 1974 Oct;113(4):1170-7
• Latest
  J:8886 Machida K, et al., Genetic control of immune response to staphylococcal exfoliative toxin A in mice. Infect Immun. 1987 Nov;55(11):2768-73