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Itga2 Gene Detail
Summary
  • Symbol
    Itga2
  • Name
    integrin alpha 2
  • Synonyms
    CD49B, DX5, VLA-2 receptor, alpha 2 subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:96600
    NCBI Gene: 16398
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:114969617-115068588 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 64.61 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3577 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96600
 protein coding gene Chr13:114969617-115068636 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020958
 protein coding gene Chr13:117572759-117678787 (-)
A/J MGP_AJ_G0020908
 protein coding gene Chr13:112798680-112899226 (-)
AKR/J MGP_AKRJ_G0020883
 protein coding gene Chr13:116199533-116299042 (-)
BALB/cJ MGP_BALBcJ_G0020908
 protein coding gene Chr13:113520935-113622038 (-)
C3H/HeJ MGP_C3HHeJ_G0020697
 protein coding gene Chr13:116026800-116129965 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021344
 protein coding gene Chr13:121004738-121107656 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018913
 protein coding gene Chr13:108076017-108169538 (-)
CAST/EiJ MGP_CASTEiJ_G0020216
 protein coding gene Chr13:115689879-115801582 (-)
CBA/J MGP_CBAJ_G0020659
 protein coding gene Chr13:125625927-125737082 (-)
DBA/2J MGP_DBA2J_G0020782
 protein coding gene Chr13:112511885-112610215 (-)
FVB/NJ MGP_FVBNJ_G0020766
 protein coding gene Chr13:111162712-111257809 (-)
LP/J MGP_LPJ_G0020858
 protein coding gene Chr13:117569062-117670814 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020794
 protein coding gene Chr13:125907292-126011654 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021380
 protein coding gene Chr13:115685549-115788041 (-)
PWK/PhJ MGP_PWKPhJ_G0019969
 protein coding gene Chr13:111297060-111399778 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019791
 protein coding gene Chr13:112025431-112132776 (-)
WSB/EiJ MGP_WSBEiJ_G0020274
 protein coding gene Chr13:116320192-116424437 (-)



Homology
more
  • Human Ortholog
    ITGA2, integrin subunit alpha 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGA2, integrin subunit alpha 2
  • Synonyms
    BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2
  • Links
    NCBI Gene ID: 3673
    neXtProt AC: NX_P17301
    UniProt: P17301

  • Chr Location
    5q11.2; chr5:52989340-53094779 (+)  GRCh38
Human Diseases
more
  • Diseases
    15 with human ITGA2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 5 alleles in 7 genetic backgrounds
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations were viable, fertile, showed no overt anatomical defects, and exhibited no bleeding anomalies. Platelet, primary fibroblast and keratinocytes from homozygous mutant mice show less efficient adhesion to collagens in vitro.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    94
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    916
  • Tissues
    140
  • cDNA Data
    10
  • Literature Summary
    28
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16398 NCBI Gene Model | MGI Sequence Detail 98972 C57BL/6J ±  kb
transcript NM_008396 RefSeq | MGI Sequence Detail 7060 C57BL/6  
polypeptide Q62469 UniProt | EBI | MGI Sequence Detail 1178 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001008 integrin alpha-2
    (term hierarchy)
  • InterPro Domains
    IPR050525 Extracellular Matrix Assembly and Organization
    IPR013517 FG-GAP repeat
    IPR013519 Integrin alpha beta-propellor
    IPR000413 Integrin alpha chain
    IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
    IPR028994 Integrin alpha, N-terminal
    IPR048285 Integrin alpha, second immunoglobulin-like domain
    IPR048286 Integrin alpha, third immunoglobulin-like domain
    IPR032695 Integrin domain superfamily
    IPR036465 von Willebrand factor A-like domain superfamily
    IPR002035 von Willebrand factor, type A
  • GlyGen
    Q62469 9 sites, 6 N-linked glycans (7 sites)
Molecular
Reagents
less
  • All nucleic 18
    cDNA 11
    Primer pair 5
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11479
References
more
  • Summaries
    All 135
    Developmental Gene Expression 28
    Gene Ontology 13
    Phenotypes 44
  • Earliest
    J:34565 Takada Y, et al., The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain. J Cell Biol. 1989 Jul;109(1):397-407
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory