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Itga2b Gene Detail
Summary
  • Symbol
    Itga2b
  • Name
    integrin alpha 2b
  • Synonyms
    alphaIIb, CD41, GpIIb, GP IIb, platelet glycoprotein IIb
  • Feature Type
    protein coding gene
  • IDs
    MGI:96601
    NCBI Gene: 16399
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:102344134-102360570 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 66.29 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    471 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96601
 protein coding gene Chr11:102344123-102360948 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019237
 protein coding gene Chr11:105430625-105448426 (-)
A/J MGP_AJ_G0019205
 protein coding gene Chr11:100981206-100998145 (-)
AKR/J MGP_AKRJ_G0019174
 protein coding gene Chr11:104100185-104117014 (-)
BALB/cJ MGP_BALBcJ_G0019179
 protein coding gene Chr11:101467364-101484646 (-)
C3H/HeJ MGP_C3HHeJ_G0018988
 protein coding gene Chr11:104309524-104327742 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019628
 protein coding gene Chr11:108718137-108735003 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017254
 protein coding gene Chr11:98407052-98424463 (-)
CAST/EiJ MGP_CASTEiJ_G0018542
 protein coding gene Chr11:105300572-105318577 (-)
CBA/J MGP_CBAJ_G0018957
 protein coding gene Chr11:113208482-113225383 (-)
DBA/2J MGP_DBA2J_G0019069
 protein coding gene Chr11:100496994-100516613 (-)
FVB/NJ MGP_FVBNJ_G0019059
 protein coding gene Chr11:100029157-100046054 (-)
LP/J MGP_LPJ_G0019138
 protein coding gene Chr11:105956061-105972820 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019090
 protein coding gene Chr11:112707842-112724659 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019666
 protein coding gene Chr11:104472166-104490049 (-)
PWK/PhJ MGP_PWKPhJ_G0018305
 protein coding gene Chr11:101566133-101583002 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018097
 protein coding gene Chr11:104226288-104243167 (-)
WSB/EiJ MGP_WSBEiJ_G0018591
 protein coding gene Chr11:104468614-104485952 (-)



Homology
more
  • Human Ortholog
    ITGA2B, integrin subunit alpha 2b
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGA2B, integrin subunit alpha 2b
  • Synonyms
    BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GT1, GTA, HPA3, PPP1R93
  • Links
    NCBI Gene ID: 3674
    neXtProt AC: NX_P08514
    UniProt: P08514

  • Chr Location
    17q21.31; chr17:44372180-44389649 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Itga2b mouse models; 4 with human ITGA2B associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    9 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit a bleeding disorder, lack platelet binding to fibrinogen, absence of fibrinogen in platelet alpha granules, and increased numbers of hematopoietic progenitors in yolk sac, fetal liver, and bone marrow.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    848
  • Tissues
    49
  • cDNA Data
    15
  • Literature Summary
    77
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16399 NCBI Gene Model | MGI Sequence Detail 16437 C57BL/6J ±  kb
    transcript NM_010575 RefSeq | MGI Sequence Detail 3287 C57BL/6  
    polypeptide Q9QUM0 UniProt | EBI | MGI Sequence Detail 1033 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000009127 integrin alpha-IIb
      (term hierarchy)
    • InterPro Domains
      IPR013517 FG-GAP repeat
      IPR013519 Integrin alpha beta-propellor
      IPR000413 Integrin alpha chain
      IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
      IPR013649 Integrin alpha, first immunoglubulin-like domain
      IPR028994 Integrin alpha, N-terminal
      IPR048285 Integrin alpha, second immunoglobulin-like domain
      IPR048286 Integrin alpha, third immunoglobulin-like domain
      IPR032695 Integrin domain superfamily
    • GlyGen
      Q9QUM0 5 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 2
      cDNA 17
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11480, MGI:2144076
    References
    more
    • Summaries
      All 193
      Developmental Gene Expression 77
      Diseases 1
      Gene Ontology 13
      Phenotypes 42
    • Earliest
      J:35481 Phillips DR, et al., GPIIb-IIIa: the responsive integrin. Cell. 1991 May 3;65(3):359-62
    • Latest
      J:352032 Wang L, et al., ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells. iScience. 2024 Jul 19;27(7):110273
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory