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Itga3 Gene Detail
Summary
  • Symbol
    Itga3
  • Name
    integrin alpha 3
  • Synonyms
    alpha3-integrin, VLA-3 alpha 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96602
    NCBI Gene: 16400
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:94935300-94967627 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 59.01 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    902 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96602
 protein coding gene Chr11:94935300-94967637 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018976
 protein coding gene Chr11:97230315-97262227 (-)
A/J MGP_AJ_G0018944
 protein coding gene Chr11:93304077-93336418 (-)
AKR/J MGP_AKRJ_G0018914
 protein coding gene Chr11:96192466-96224623 (-)
BALB/cJ MGP_BALBcJ_G0018917
 protein coding gene Chr11:93775591-93807673 (-)
C3H/HeJ MGP_C3HHeJ_G0018731
 protein coding gene Chr11:96317380-96350819 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019369
 protein coding gene Chr11:100292495-100324566 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017000
 protein coding gene Chr11:90790560-90822386 (-)
CAST/EiJ MGP_CASTEiJ_G0018285
 protein coding gene Chr11:97107468-97141311 (-)
CBA/J MGP_CBAJ_G0018702
 protein coding gene Chr11:104386703-104424328 (-)
DBA/2J MGP_DBA2J_G0018810
 protein coding gene Chr11:92878733-92910917 (-)
FVB/NJ MGP_FVBNJ_G0018799
 protein coding gene Chr11:92341118-92373435 (-)
LP/J MGP_LPJ_G0018880
 protein coding gene Chr11:97792940-97827495 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018826
 protein coding gene Chr11:104441476-104475270 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019409
 protein coding gene Chr11:96450858-96485111 (-)
PWK/PhJ MGP_PWKPhJ_G0018056
 protein coding gene Chr11:93792105-93825343 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017845
 protein coding gene Chr11:96136061-96167718 (-)
WSB/EiJ MGP_WSBEiJ_G0018334
 protein coding gene Chr11:96368080-96402109 (-)



Homology
more
  • Human Ortholog
    ITGA3, integrin subunit alpha 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGA3, integrin subunit alpha 3
  • Synonyms
    CD49C, FRP-2, GAP-B3, GAPB3, ILNEB, JEB7, MSK18, VCA-2, VL3A, VLA3a
  • Links
    NCBI Gene ID: 3675
    neXtProt AC: NX_P26006
    UniProt: P26006

  • Chr Location
    17q21.33; chr17:50055968-50090481 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ITGA3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 5 alleles in 8 genetic backgrounds
    35 phenotypes from multigenic genotypes
    4 images
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit defects of the kidney and submandibular gland, decreased bronchial branching of the lungs, skin blisters at the dermal-epidermal junction, abnormal layering of the cerebral cortex and perinatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    106
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1376
  • Tissues
    408
  • cDNA Data
    78
  • Literature Summary
    69
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001507 Ensembl Gene Model | MGI Sequence Detail 32328 C57BL/6J ±  kb
    transcript ENSMUST00000120375 Ensembl | MGI Sequence Detail 4697 Not Applicable  
    polypeptide ENSMUSP00000113556 Ensembl | MGI Sequence Detail 1068 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000009128 integrin alpha-3
      (term hierarchy)
    • InterPro Domains
      IPR013517 FG-GAP repeat
      IPR013519 Integrin alpha beta-propellor
      IPR000413 Integrin alpha chain
      IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
      IPR013649 Integrin alpha, first immunoglubulin-like domain
      IPR028994 Integrin alpha, N-terminal
      IPR048285 Integrin alpha, second immunoglobulin-like domain
      IPR048286 Integrin alpha, third immunoglobulin-like domain
      IPR032695 Integrin domain superfamily
    • GlyGen
      Q62470 13 sites, 16 N-linked glycans (11 sites)
    Molecular
    Reagents
    less
    • All nucleic 88
      Genomic 1
      cDNA 79
      Primer pair 6
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-11481, MGI:2143964
    References
    more
    • Summaries
      All 192
      Developmental Gene Expression 69
      Gene Ontology 19
      Phenotypes 71
    • Earliest
      J:41315 Tamura RN, et al., Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10183-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory