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Itga5 Gene Detail
Summary
  • Symbol
    Itga5
  • Name
    integrin alpha 5 (fibronectin receptor alpha)
  • Synonyms
    Cd49e, Fnra
  • Feature Type
    protein coding gene
  • IDs
    MGI:96604
    NCBI Gene: 16402
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:103252713-103275190 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 58.90 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    397 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96604
 protein coding gene Chr15:103252713-103275218 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022440
 protein coding gene Chr15:105613979-105637523 (-)
A/J MGP_AJ_G0022402
 protein coding gene Chr15:101429212-101451401 (-)
AKR/J MGP_AKRJ_G0022377
 protein coding gene Chr15:104510453-104532780 (-)
BALB/cJ MGP_BALBcJ_G0022406
 protein coding gene Chr15:101472788-101500846 (-)
C3H/HeJ MGP_C3HHeJ_G0022173
 protein coding gene Chr15:104603520-104630448 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022855
 protein coding gene Chr15:109498241-109522881 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020378
 protein coding gene Chr15:97190359-97215181 (-)
CAST/EiJ MGP_CASTEiJ_G0021699
 protein coding gene Chr15:105474090-105496337 (-)
CBA/J MGP_CBAJ_G0022142
 protein coding gene Chr15:113357800-113379990 (-)
DBA/2J MGP_DBA2J_G0022273
 protein coding gene Chr15:100704116-100726664 (-)
FVB/NJ MGP_FVBNJ_G0022249
 protein coding gene Chr15:99763221-99785525 (-)
LP/J MGP_LPJ_G0022342
 protein coding gene Chr15:105745209-105785768 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022271
 protein coding gene Chr15:116847288-116869415 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022867
 protein coding gene Chr15:104543227-104566664 (-)
PWK/PhJ MGP_PWKPhJ_G0021439
 protein coding gene Chr15:100884084-100906788 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021271
 protein coding gene Chr15:104381615-104404892 (-)
WSB/EiJ MGP_WSBEiJ_G0021749
 protein coding gene Chr15:105169872-105192294 (-)



Homology
more
  • Human Ortholog
    ITGA5, integrin subunit alpha 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGA5, integrin subunit alpha 5
  • Synonyms
    CD49e, FNRA, VLA-5, VLA5A
  • Links
    NCBI Gene ID: 3678
    neXtProt AC: NX_P08648
    UniProt: P08648

  • Chr Location
    12q13.13; chr12:54395261-54419266 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 5 genetic backgrounds
    13 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit severe defects in posterior trunk and yolk sac mesodermal structures, lack of epithelialization of somites, reduced numbers of Schwann cells, and lethality around embryonic day 10-11.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    84
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    908
  • Tissues
    124
  • cDNA Data
    69
  • Literature Summary
    69
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000555 Ensembl Gene Model | MGI Sequence Detail 22478 C57BL/6J ±  kb
    transcript ENSMUST00000023128 Ensembl | MGI Sequence Detail 4382 Not Applicable  
    polypeptide ENSMUSP00000023128 Ensembl | MGI Sequence Detail 1053 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000009130 integrin alpha-5
      (term hierarchy)
    • InterPro Domains
      IPR013517 FG-GAP repeat
      IPR013519 Integrin alpha beta-propellor
      IPR000413 Integrin alpha chain
      IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
      IPR013649 Integrin alpha, first immunoglubulin-like domain
      IPR028994 Integrin alpha, N-terminal
      IPR048285 Integrin alpha, second immunoglobulin-like domain
      IPR048286 Integrin alpha, third immunoglobulin-like domain
      IPR032695 Integrin domain superfamily
    • GlyGen
      P11688 15 sites, 5 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 82
      Genomic 2
      cDNA 72
      Primer pair 6
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11483, MGD-MRK-9851
    References
    more
    • Summaries
      All 217
      Developmental Gene Expression 69
      Gene Ontology 19
      Phenotypes 46
    • Earliest
      J:31505 Holers VM, et al., Molecular cloning of a murine fibronectin receptor and its expression during inflammation. Expression of VLA-5 is increased in activated peritoneal macrophages in a manner discordant from major histocompatibility complex class II. J Exp Med. 1989 May 1;169(5):1589-605
    • Latest
      J:354189 Miao L, et al., beta1 integrins regulate cellular behaviour and cardiomyocyte organization during ventricular wall formation. Cardiovasc Res. 2024 Sep 21;120(11):1279-1294
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory