About   Help   FAQ
Itgax Gene Detail
Summary
  • Symbol
    Itgax
  • Name
    integrin alpha X
  • Synonyms
    Cd11c, CD11C (p150) alpha polypeptide, CR4
  • Feature Type
    protein coding gene
  • IDs
    MGI:96609
    NCBI Gene: 16411
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127728719-127749829 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    766 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96609
 protein coding gene Chr7:127728697-127749829 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033072
 protein coding gene Chr7:132534286-132556840 (+)
A/J MGP_AJ_G0033055
 protein coding gene Chr7:128971104-128992074 (+)
AKR/J MGP_AKRJ_G0032987
 protein coding gene Chr7:132331839-132354128 (+)
BALB/cJ MGP_BALBcJ_G0033056
 protein coding gene Chr7:128634892-128655981 (+)
C3H/HeJ MGP_C3HHeJ_G0032770
 protein coding gene Chr7:132224092-132252015 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033566
 protein coding gene Chr7:137695220-137723576 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030538
 protein coding gene Chr7:130154871-130180812 (+)
CAST/EiJ MGP_CASTEiJ_G0032099
 protein coding gene Chr7:124012700-124040361 (+)
CBA/J MGP_CBAJ_G0032743
 protein coding gene Chr7:142390585-142416227 (+)
DBA/2J MGP_DBA2J_G0032895
 protein coding gene Chr7:126954708-126977304 (+)
FVB/NJ MGP_FVBNJ_G0032848
 protein coding gene Chr7:126821412-126842562 (+)
LP/J MGP_LPJ_G0032989
 protein coding gene Chr7:134006805-134030896 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032880
 protein coding gene Chr7:143442129-143465452 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033585
 protein coding gene Chr7:131306805-131330050 (+)
PWK/PhJ MGP_PWKPhJ_G0031806
 protein coding gene Chr7:119960797-119983253 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031652
 protein coding gene Chr7:118106312-118127928 (+)
WSB/EiJ MGP_WSBEiJ_G0032211
 protein coding gene Chr7:132279083-132300580 (+)



Homology
more
  • Human Ortholog
    ITGAX, integrin subunit alpha X
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGAX, integrin subunit alpha X
  • Synonyms
    CD11C, SLEB6
  • Links
    NCBI Gene ID: 3687
    neXtProt AC: NX_P20702
    UniProt: P20702

  • Chr Location
    16p11.2; chr16:31355134-31382999 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection, decreased susceptibility to experimental autoimmune encephalomyelitis (EAE), increased T cell proliferation, and an abnormal pattern of cytokine production during EAE.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    739
  • Tissues
    19
  • cDNA Data
    25
  • Literature Summary
    30
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030789 Ensembl Gene Model | MGI Sequence Detail 21111 C57BL/6J ±  kb
transcript ENSMUST00000033053 Ensembl | MGI Sequence Detail 4046 Not Applicable  
polypeptide ENSMUSP00000033053 Ensembl | MGI Sequence Detail 1169 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000001013 integrin alpha-X
    (term hierarchy)
  • InterPro Domains
    IPR050525 Extracellular Matrix Assembly and Organization
    IPR013517 FG-GAP repeat
    IPR013519 Integrin alpha beta-propellor
    IPR000413 Integrin alpha chain
    IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
    IPR013649 Integrin alpha, first immunoglubulin-like domain
    IPR028994 Integrin alpha, N-terminal
    IPR048285 Integrin alpha, second immunoglobulin-like domain
    IPR048633 Integrin alpha-X-like, third Ig-like domain
    IPR032695 Integrin domain superfamily
    IPR036465 von Willebrand factor A-like domain superfamily
    IPR002035 von Willebrand factor, type A
  • GlyGen
    Q9QXH4 7 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 27
    Genomic 1
    cDNA 25
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11488, MGI:2141963
References
more
  • Summaries
    All 158
    Developmental Gene Expression 30
    Gene Ontology 17
    Phenotypes 28
  • Earliest
    J:10461 Metlay JP, et al., The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J Exp Med. 1990 May 1;171(5):1753-71
  • Latest
    J:354496 Stark K, et al., Antibodies and complement are key drivers of thrombosis. Immunity. 2024 Sep 10;57(9):2140-2156.e10
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory