Itgb7 MGI Mouse Gene Detail - MGI:96616

Symbol

Itgb7
Name

integrin beta 7

Feature Type

protein coding gene
IDs

MGI:96616
NCBI Gene: 16421
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:102124430-102140379 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 57.39 cM
Mapping Data

8 experiments

SNPs within 2kb

516 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96616	protein coding gene	Chr15:102124429-102141840 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022404	protein coding gene	Chr15:104372124-104388008 (-)
A/J	MGP_AJ_G0022366	protein coding gene	Chr15:100275409-100291340 (-)
AKR/J	MGP_AKRJ_G0022341	protein coding gene	Chr15:103307409-103323364 (-)
BALB/cJ	MGP_BALBcJ_G0022370	protein coding gene	Chr15:100319821-100335637 (-)
C3H/HeJ	MGP_C3HHeJ_G0022137	protein coding gene	Chr15:103384982-103400628 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022819	protein coding gene	Chr15:108252041-108268021 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020342	protein coding gene	Chr15:96051771-96068307 (-)
CAST/EiJ	MGP_CASTEiJ_G0021663	protein coding gene	Chr15:104246029-104265887 (-)
CBA/J	MGP_CBAJ_G0022106	protein coding gene	Chr15:112047487-112063439 (-)
DBA/2J	MGP_DBA2J_G0022237	protein coding gene	Chr15:99563519-99579579 (-)
FVB/NJ	MGP_FVBNJ_G0022213	protein coding gene	Chr15:98624471-98640481 (-)
LP/J	MGP_LPJ_G0022306	protein coding gene	Chr15:104534259-104550230 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022235	protein coding gene	Chr15:115626819-115642752 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022831	protein coding gene	Chr15:103333379-103350522 (-)
PWK/PhJ	MGP_PWKPhJ_G0021403	protein coding gene	Chr15:99713722-99730023 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021235	protein coding gene	Chr15:103183972-103199835 (-)
WSB/EiJ	MGP_WSBEiJ_G0021713	protein coding gene	Chr15:103966466-103982352 (-)

Human Ortholog

ITGB7, integrin subunit beta 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ITGB7, integrin subunit beta 7
Links

HGNC:6162

NCBI Gene ID: 3695

neXtProt AC: NX_P26010

UniProt: P26010
Chr Location

12q13.13; chr12:53191323-53207282 (-) GRCh38

MGI Vertebrate Homology

Itgb7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ITGB7
Protein SuperFamily

Integrin_B
Gene Tree

Itgb7

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References

1 with disease annotations

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Phenotype Summary

21 phenotypes from 2 alleles in 2 genetic backgrounds
5 phenotypes from multigenic genotypes
91 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

43
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

28
Radiation induced

2
Targeted

7
Genomic Mutations

3 involving Itgb7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

72 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display hypoplasia of gut-associated lymph tissue due to defects in lymphocyte migration

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All GO Annotations

32
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

17
cDNA Data

32
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase itgb7

ZFIN itgb7

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All Sequences

52
RefSeq

6
UniProt

4
CCDS

CCDS49740.1

Ensembl

ENSMUSG00000001281 (Evidence)
NCBI Gene

16421

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001281	Ensembl Gene Model \| MGI Sequence Detail	15950	C57BL/6J	± kb
transcript	ENSMUST00000001327	Ensembl \| MGI Sequence Detail	2683	Not Applicable
polypeptide	ENSMUSP00000001327	Ensembl \| MGI Sequence Detail	806	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009143 integrin beta-7

(term hierarchy)
InterPro Domains

IPR013111 EGF-like domain, extracellular

IPR040622 Integrin beta, epidermal growth factor-like domain 1

IPR033760 Integrin beta N-terminal

IPR015812 Integrin beta subunit

IPR014836 Integrin beta subunit, cytoplasmic domain

IPR012896 Integrin beta subunit, tail

IPR002369 Integrin beta subunit, VWA domain

IPR036349 Integrin beta tail domain superfamily

IPR032695 Integrin domain superfamily

IPR016201 PSI domain

IPR036465 von Willebrand factor A-like domain superfamily
GlyGen

P26011 8 sites

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All nucleic 35

Genomic 3

cDNA 32

Microarray probesets 4

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MGD-MRK-11495

Summaries

All 151

Developmental Gene Expression 6

Diseases 1

Gene Ontology 7

Phenotypes 91
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:338516 Kamioka Y, et al., Distinct bidirectional regulation of LFA1 and alpha4beta7 by Rap1 and integrin adaptors in T cells under shear flow. Cell Rep. 2023 Jun 1;42(6):112580

TSS for Itgb7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136667	Chr15:102140355-102140376 (-)	13 bp
Tssr136666	Chr15:102140330-102140352 (-)	38 bp
Tssr136665	Chr15:102132928-102132938 (-)	7,446 bp
Tssr136664	Chr15:102132895-102132900 (-)	7,481 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24