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Itih3 Gene Detail
Summary
  • Symbol
    Itih3
  • Name
    inter-alpha trypsin inhibitor, heavy chain 3
  • Synonyms
    Intin3, Itih-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96620
    NCBI Gene: 16426
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:30630529-30645717 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 19.09 cM, cytoband A2-C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    530 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96620
 protein coding gene Chr14:30630529-30645748 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021111
 protein coding gene Chr14:24060789-24077736 (-)
A/J MGP_AJ_G0021059
 protein coding gene Chr14:23161704-23176834 (-)
AKR/J MGP_AKRJ_G0021036
 protein coding gene Chr14:24276784-24294264 (-)
BALB/cJ MGP_BALBcJ_G0021063
 protein coding gene Chr14:23262699-23278213 (-)
C3H/HeJ MGP_C3HHeJ_G0020846
 protein coding gene Chr14:24132555-24147668 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021495
 protein coding gene Chr14:25026303-25042082 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019058
 protein coding gene Chr14:23221781-23237169 (-)
CAST/EiJ MGP_CASTEiJ_G0020371
 protein coding gene Chr14:23894078-23911890 (-)
CBA/J MGP_CBAJ_G0020813
 protein coding gene Chr14:25976108-25996868 (-)
DBA/2J MGP_DBA2J_G0020935
 protein coding gene Chr14:23187227-23203286 (-)
FVB/NJ MGP_FVBNJ_G0020919
 protein coding gene Chr14:23144008-23159631 (-)
LP/J MGP_LPJ_G0021004
 protein coding gene Chr14:24390950-24408845 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020945
 protein coding gene Chr14:25249550-25266558 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021528
 protein coding gene Chr14:24029013-24046323 (-)
PWK/PhJ MGP_PWKPhJ_G0020119
 protein coding gene Chr14:22635916-22651815 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019943
 protein coding gene Chr14:23611239-23626416 (-)
WSB/EiJ MGP_WSBEiJ_G0020426
 protein coding gene Chr14:24090184-24105287 (-)



Homology
more
  • Human Ortholog
    ITIH3, inter-alpha-trypsin inhibitor heavy chain 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITIH3, inter-alpha-trypsin inhibitor heavy chain 3
  • Synonyms
    H3P, ITI-HC3, SHAP
  • Links
    NCBI Gene ID: 3699
    neXtProt AC: NX_Q06033
    UniProt: Q06033

  • Chr Location
    3p21.1; chr3:52794768-52808799 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    751
  • Tissues
    19
  • cDNA Data
    46
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000006522 Ensembl Gene Model | MGI Sequence Detail 15189 C57BL/6J ±  kb
transcript ENSMUST00000006697 Ensembl | MGI Sequence Detail 2992 Not Applicable  
polypeptide ENSMUSP00000006697 Ensembl | MGI Sequence Detail 889 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000009148 inter-alpha-trypsin inhibitor heavy chain H3
    (term hierarchy)
  • InterPro Domains
    IPR050934 Inter-alpha-trypsin inhibitor heavy chain
    IPR010600 Inter-alpha-trypsin inhibitor heavy chain, C-terminal
    IPR013694 VIT domain
    IPR036465 von Willebrand factor A-like domain superfamily
    IPR002035 von Willebrand factor, type A
  • GlyGen
    Q61704 5 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 51
    cDNA 49
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11436, MGD-MRK-11499, MGD-MRK-11502, MGI:2145798
References
more
  • Summaries
    All 37
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:2174 Salier JP, et al., Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily. Genomics. 1992 Sep;14(1):83-8
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory