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Kcna3 Gene Detail
Summary
  • Symbol
    Kcna3
  • Name
    potassium voltage-gated channel, shaker-related subfamily, member 3
  • Synonyms
    Kca1-3, Kv1.3, Mk-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96660
    NCBI Gene: 16491
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:106943485-106945386 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 46.59 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    59 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96660
 protein coding gene Chr3:106943485-106947223 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027739
 protein coding gene Chr3:108501442-108503343 (+)
A/J MGP_AJ_G0027699
 protein coding gene Chr3:105065051-105066952 (+)
AKR/J MGP_AKRJ_G0027664
 protein coding gene Chr3:107637080-107638981 (+)
BALB/cJ MGP_BALBcJ_G0027711
 protein coding gene Chr3:104762981-104764882 (+)
C3H/HeJ MGP_C3HHeJ_G0027441
 protein coding gene Chr3:107969963-107974314 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028155
 protein coding gene Chr3:112575453-112579095 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025493
 protein coding gene Chr3:101222414-101224312 (+)
CAST/EiJ MGP_CASTEiJ_G0026897
 protein coding gene Chr3:107335363-107337265 (+)
CBA/J MGP_CBAJ_G0027416
 protein coding gene Chr3:116358784-116360685 (+)
DBA/2J MGP_DBA2J_G0027558
 protein coding gene Chr3:104269087-104270988 (+)
FVB/NJ MGP_FVBNJ_G0027526
 protein coding gene Chr3:102146967-102148868 (+)
LP/J MGP_LPJ_G0027665
 protein coding gene Chr3:109922063-109923964 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027556
 protein coding gene Chr3:122488396-122490297 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028210
 protein coding gene Chr3:107217793-107219695 (+)
PWK/PhJ MGP_PWKPhJ_G0026623
 protein coding gene Chr3:103988480-103990407 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026443
 protein coding gene Chr3:105360165-105362067 (+)
WSB/EiJ MGP_WSBEiJ_G0026977
 protein coding gene Chr3:107748177-107750078 (+)



Homology
more
  • Human Ortholog
    KCNA3, potassium voltage-gated channel subfamily A member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNA3, potassium voltage-gated channel subfamily A member 3
  • Synonyms
    HGK5, HLK3, HPCN3, HUKIII, KV1.3, MK3, PCN3
  • Links
    NCBI Gene ID: 3738
    neXtProt AC: NX_P22001
    UniProt: P22001

  • Chr Location
    1p13.3; chr1:110653560-110674940 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display no apparent immune system defects. Mice homozygous for a different knock-out allele show reduced body weight, increased basal metabolic rate, resistance to diet-induced obesity, increased insulin sensitivity, and altered peripheral glucose metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    16
  • cDNA Data
    8
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000047959 Ensembl Gene Model | MGI Sequence Detail 1902 C57BL/6J ±  kb
    transcript ENSMUST00000052718 Ensembl | MGI Sequence Detail 1902 Not Applicable  
    polypeptide ENSMUSP00000050680 Ensembl | MGI Sequence Detail 528 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000000811 voltage-gated potassium channel subunit KCNA3
      (term hierarchy)
    • InterPro Domains
      IPR000210 BTB/POZ domain
      IPR005821 Ion transport domain
      IPR003131 Potassium channel tetramerisation-type BTB domain
      IPR003968 Potassium channel, voltage dependent, Kv
      IPR003972 Potassium channel, voltage dependent, Kv1
      IPR004050 Potassium channel, voltage dependent, Kv1.3
      IPR011333 SKP1/BTB/POZ domain superfamily
      IPR027359 Voltage-dependent channel domain superfamily
    • GlyGen
      P16390 2 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 5
      cDNA 8
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11556, MGD-MRK-11564, MGD-MRK-12250
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 7
      Phenotypes 30
    • Earliest
      J:10326 Chandy KG, et al., A family of three mouse potassium channel genes with intronless coding regions. Science. 1990 Feb 23;247(4945):973-5
    • Latest
      J:333990 Huffstetler CM, et al., Single cannabidiol administration affects anxiety-, obsessive compulsive-, object memory-, and attention-like behaviors in mice in a sex and concentration dependent manner. Pharmacol Biochem Behav. 2023 Jan;222:173498
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory