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Kcna4 Gene Detail
Summary
  • Symbol
    Kcna4
  • Name
    potassium voltage-gated channel, shaker-related subfamily, member 4
  • Synonyms
    Kv1.4
  • Feature Type
    protein coding gene
  • IDs
    MGI:96661
    NCBI Gene: 16492
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:107120984-107128847 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 56.12 cM, cytoband E
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    175 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96661
 protein coding gene Chr2:107120934-107157149 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026237
 protein coding gene Chr2:109533732-109541595 (+)
A/J MGP_AJ_G0026198
 protein coding gene Chr2:104954521-104962366 (+)
AKR/J MGP_AKRJ_G0026178
 protein coding gene Chr2:107845701-107853625 (+)
BALB/cJ MGP_BALBcJ_G0026207
 protein coding gene Chr2:105242883-105250744 (+)
C3H/HeJ MGP_C3HHeJ_G0025957
 protein coding gene Chr2:108167142-108174969 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026658
 protein coding gene Chr2:113097834-113105985 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024044
 protein coding gene Chr2:100720250-100728144 (+)
CAST/EiJ MGP_CASTEiJ_G0025422
 protein coding gene Chr2:108675415-108683214 (+)
CBA/J MGP_CBAJ_G0025935
 protein coding gene Chr2:117038655-117049231 (+)
DBA/2J MGP_DBA2J_G0026073
 protein coding gene Chr2:104496953-104504798 (+)
FVB/NJ MGP_FVBNJ_G0026036
 protein coding gene Chr2:103456844-103464709 (+)
LP/J MGP_LPJ_G0026176
 protein coding gene Chr2:109715365-109723295 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026060
 protein coding gene Chr2:120828497-120836348 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026712
 protein coding gene Chr2:108034991-108042854 (+)
PWK/PhJ MGP_PWKPhJ_G0025157
 protein coding gene Chr2:104075168-104083305 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024957
 protein coding gene Chr2:107272634-107280509 (+)
WSB/EiJ MGP_WSBEiJ_G0025489
 protein coding gene Chr2:108764594-108772461 (+)



Homology
more
  • Human Ortholog
    KCNA4, potassium voltage-gated channel subfamily A member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNA4, potassium voltage-gated channel subfamily A member 4
  • Synonyms
    HBK4, HK1, HPCN2, HUKII, KCNA4L, KCNA8, KV1.4, MCIDDS, PCN2
  • Links
    NCBI Gene ID: 3739
    neXtProt AC: NX_P22459
    UniProt: P22459

  • Chr Location
    11p14.1; chr11:30009730-30017030 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, fertile and grossly normal; however, a small subset of mutants exhibit spontaneous seizure activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    28
  • cDNA Data
    5
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042604 Ensembl Gene Model | MGI Sequence Detail 7864 C57BL/6J ±  kb
transcript ENSMUST00000037012 Ensembl | MGI Sequence Detail 4792 Not Applicable  
polypeptide ENSMUSP00000037958 Ensembl | MGI Sequence Detail 654 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000000683 voltage-gated potassium channel alpha subunit KCNA4
    (term hierarchy)
  • InterPro Domains
    IPR000210 BTB/POZ domain
    IPR005821 Ion transport domain
    IPR003131 Potassium channel tetramerisation-type BTB domain
    IPR003968 Potassium channel, voltage dependent, Kv
    IPR003972 Potassium channel, voltage dependent, Kv1
    IPR020467 Potassium channel, voltage dependent, Kv1.4
    IPR012897 Potassium channel, voltage dependent, Kv1.4, tandem inactivation domain
    IPR037065 Potassium channel, voltage dependent, Kv1.4, tandem inactivation domain superfamily
    IPR011333 SKP1/BTB/POZ domain superfamily
    IPR027359 Voltage-dependent channel domain superfamily
    IPR028325 Voltage-gated potassium channel
  • GlyGen
    Q61423 2 sites, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 11
    Genomic 4
    cDNA 6
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11565
References
more
  • Summaries
    All 64
    Developmental Gene Expression 6
    Gene Ontology 13
    Phenotypes 16
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:297966 Gonzalez-Alvarado MN, et al., Functional role of endogenous Kv1.4 in experimental demyelination. J Neuroimmunol. 2020 Jun 15;343:577227
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory