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Kcna7 Gene Detail
Summary
  • Symbol
    Kcna7
  • Name
    potassium voltage-gated channel, shaker-related subfamily, member 7
  • Synonyms
    Kv1.7
  • Feature Type
    protein coding gene
  • IDs
    MGI:96664
    NCBI Gene: 16495
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45055077-45059187 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    192 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96664
 protein coding gene Chr7:45055077-45060806 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032218
 protein coding gene Chr7:45660926-45666355 (+)
A/J MGP_AJ_G0032197
 protein coding gene Chr7:44792684-44798103 (+)
AKR/J MGP_AKRJ_G0032133
 protein coding gene Chr7:46024821-46030246 (+)
BALB/cJ MGP_BALBcJ_G0032209
 protein coding gene Chr7:44781661-44787084 (+)
C3H/HeJ MGP_C3HHeJ_G0031925
 protein coding gene Chr7:46512543-46517972 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032701
 protein coding gene Chr7:47928858-47934284 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029715
 protein coding gene Chr7:47343643-47349021 (+)
CAST/EiJ MGP_CASTEiJ_G0031253
 protein coding gene Chr7:37925131-37930510 (+)
CBA/J MGP_CBAJ_G0031889
 protein coding gene Chr7:49513135-49518559 (+)
DBA/2J MGP_DBA2J_G0032047
 protein coding gene Chr7:44455253-44460677 (+)
FVB/NJ MGP_FVBNJ_G0031998
 protein coding gene Chr7:44240734-44246158 (+)
LP/J MGP_LPJ_G0032125
 protein coding gene Chr7:46361407-46366819 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032035
 protein coding gene Chr7:48213361-48218780 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032717
 protein coding gene Chr7:45245945-45251360 (+)
PWK/PhJ MGP_PWKPhJ_G0030976
 protein coding gene Chr7:37829535-37835006 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030813
 protein coding gene Chr7:33257269-33262651 (+)
WSB/EiJ MGP_WSBEiJ_G0031370
 protein coding gene Chr7:45739700-45745114 (+)



Homology
more
  • Human Ortholog
    KCNA7, potassium voltage-gated channel subfamily A member 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNA7, potassium voltage-gated channel subfamily A member 7
  • Synonyms
    HAK6, KV1.7
  • Links
    NCBI Gene ID: 3743
    neXtProt AC: NX_Q96RP8
    UniProt: Q96RP8

  • Chr Location
    19q13.33; chr19:49067397-49072699 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    5
  • cDNA Data
    5
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038201 Ensembl Gene Model | MGI Sequence Detail 4111 C57BL/6J ±  kb
    transcript ENSMUST00000107774 Ensembl | MGI Sequence Detail 2182 Not Applicable  
    polypeptide ENSMUSP00000103403 Ensembl | MGI Sequence Detail 489 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000000814 voltage-gated potassium channel subunit KCNA7
      (term hierarchy)
    • InterPro Domains
      IPR000210 BTB/POZ domain
      IPR005821 Ion transport domain
      IPR003131 Potassium channel tetramerisation-type BTB domain
      IPR003968 Potassium channel, voltage dependent, Kv
      IPR003972 Potassium channel, voltage dependent, Kv1
      IPR048219 Potassium voltage-gated channel subfamily A member 7, BTB/POZ domain
      IPR011333 SKP1/BTB/POZ domain superfamily
      IPR027359 Voltage-dependent channel domain superfamily
    • GlyGen
      Q17ST2 1 site
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 1
      cDNA 6
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11568
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:17629 Lock LF, et al., Voltage-gated potassium channel genes are clustered in paralogous regions of the mouse genome. Genomics. 1994 Apr;20(3):354-62
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory