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Kcnc3 Gene Detail
Summary
  • Symbol
    Kcnc3
  • Name
    potassium voltage gated channel, Shaw-related subfamily, member 3
  • Synonyms
    Kcr2-3, KShIIID, Kv3.3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96669
    NCBI Gene: 16504
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44240088-44254178 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.85 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    282 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96669
 protein coding gene Chr7:44236405-44254178 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032171
 protein coding gene Chr7:44771103-44785612 (+)
A/J MGP_AJ_G0032150
 protein coding gene Chr7:43950749-43964608 (+)
AKR/J MGP_AKRJ_G0032086
 protein coding gene Chr7:45157503-45171504 (+)
BALB/cJ MGP_BALBcJ_G0032162
 protein coding gene Chr7:43948019-43961879 (+)
C3H/HeJ MGP_C3HHeJ_G0031878
 protein coding gene Chr7:45648072-45663038 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032654
 protein coding gene Chr7:47029710-47043578 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029668
 protein coding gene Chr7:46532120-46546090 (+)
CAST/EiJ MGP_CASTEiJ_G0031206
 protein coding gene Chr7:37026864-37040748 (+)
CBA/J MGP_CBAJ_G0031842
 protein coding gene Chr7:48580832-48594743 (+)
DBA/2J MGP_DBA2J_G0032000
 protein coding gene Chr7:43622394-43636269 (+)
FVB/NJ MGP_FVBNJ_G0031951
 protein coding gene Chr7:43368912-43384308 (+)
LP/J MGP_LPJ_G0032078
 protein coding gene Chr7:45455158-45469083 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031988
 protein coding gene Chr7:47312488-47338083 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032670
 protein coding gene Chr7:44376843-44391453 (+)
PWK/PhJ MGP_PWKPhJ_G0030929
 protein coding gene Chr7:36972752-36989328 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030766
 protein coding gene Chr7:32383136-32396919 (+)
WSB/EiJ MGP_WSBEiJ_G0031323
 protein coding gene Chr7:44843210-44857005 (+)



Homology
more
  • Human Ortholog
    KCNC3, potassium voltage-gated channel subfamily C member 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNC3, potassium voltage-gated channel subfamily C member 3
  • Synonyms
    KSHIIID, KV3.3, SCA13
  • Links
    NCBI Gene ID: 3748
    neXtProt AC: NX_Q14003
    UniProt: Q14003

  • Chr Location
    19q13.33; chr19:50311937-50333536 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KCNC3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozgous null mice show no overt phenotype, though mutation of this locus in conjunction with mutations in another potassium channel results in alcohol hypersensitivty, increased locomotion, and spontaneous myoclonus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    771
  • Tissues
    19
  • cDNA Data
    18
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062785 Ensembl Gene Model | MGI Sequence Detail 14091 C57BL/6J ±  kb
    transcript ENSMUST00000107906 Ensembl | MGI Sequence Detail 5062 Not Applicable  
    polypeptide ENSMUSP00000103539 Ensembl | MGI Sequence Detail 770 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000009254 voltage-gated potassium channel KCNC3
      (term hierarchy)
    • InterPro Domains
      IPR000210 BTB/POZ domain
      IPR005821 Ion transport domain
      IPR003131 Potassium channel tetramerisation-type BTB domain
      IPR003968 Potassium channel, voltage dependent, Kv
      IPR003974 Potassium channel, voltage dependent, Kv3
      IPR005404 Potassium channel, voltage dependent, Kv3.3
      IPR011333 SKP1/BTB/POZ domain superfamily
      IPR027359 Voltage-dependent channel domain superfamily
      IPR028325 Voltage-gated potassium channel
    • GlyGen
      Q63959 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 2
      cDNA 20
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11573, MGD-MRK-11581
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 4
      Gene Ontology 14
      Phenotypes 23
    • Earliest
      J:2312 Ghanshani S, et al., Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. Genomics. 1992 Feb;12(2):190-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory