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Kcnc4 Gene Detail
Summary
  • Symbol
    Kcnc4
  • Name
    potassium voltage gated channel, Shaw-related subfamily, member 4
  • Synonyms
    Kcr2-4, Kv3.4
  • Feature Type
    protein coding gene
  • IDs
    MGI:96670
    NCBI Gene: 99738
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:107345619-107366868 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 46.83 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    487 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96670
 protein coding gene Chr3:107345614-107367617 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027748
 protein coding gene Chr3:108932148-108953570 (-)
A/J MGP_AJ_G0027708
 protein coding gene Chr3:105483880-105505077 (-)
AKR/J MGP_AKRJ_G0027673
 protein coding gene Chr3:108056959-108078202 (-)
BALB/cJ MGP_BALBcJ_G0027720
 protein coding gene Chr3:105174129-105195372 (-)
C3H/HeJ MGP_C3HHeJ_G0027450
 protein coding gene Chr3:108398005-108419271 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028164
 protein coding gene Chr3:113019232-113040593 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025502
 protein coding gene Chr3:101636581-101657478 (-)
CAST/EiJ MGP_CASTEiJ_G0026906
 protein coding gene Chr3:107776315-107797531 (-)
CBA/J MGP_CBAJ_G0027425
 protein coding gene Chr3:116844912-116866127 (-)
DBA/2J MGP_DBA2J_G0027567
 protein coding gene Chr3:104677709-104698987 (-)
FVB/NJ MGP_FVBNJ_G0027535
 protein coding gene Chr3:102555367-102576886 (-)
LP/J MGP_LPJ_G0027674
 protein coding gene Chr3:110356825-110378187 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027565
 protein coding gene Chr3:122954801-122976045 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028219
 protein coding gene Chr3:107654517-107675778 (-)
PWK/PhJ MGP_PWKPhJ_G0026632
 protein coding gene Chr3:104411631-104433078 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026452
 protein coding gene Chr3:105775962-105797096 (-)
WSB/EiJ MGP_WSBEiJ_G0026986
 protein coding gene Chr3:108178561-108199805 (-)



Homology
more
  • Human Ortholog
    KCNC4, potassium voltage-gated channel subfamily C member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNC4, potassium voltage-gated channel subfamily C member 4
  • Synonyms
    C1orf30, HKSHIIIC, KSHIIIC, KV3.4
  • Links
    NCBI Gene ID: 3749
    neXtProt AC: NX_Q03721
    UniProt: Q03721

  • Chr Location
    1p13.3; chr1:110210314-110284080 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    876
  • Tissues
    27
  • cDNA Data
    10
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027895 Ensembl Gene Model | MGI Sequence Detail 21250 C57BL/6J ±  kb
transcript ENSMUST00000238670 Ensembl | MGI Sequence Detail 2664 Not Applicable  
polypeptide ENSMUSP00000158751 Ensembl | MGI Sequence Detail 666 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000000783 voltage-gated potassium channel KCNC4
    (term hierarchy)
  • InterPro Domains
    IPR000210 BTB/POZ domain
    IPR005821 Ion transport domain
    IPR003131 Potassium channel tetramerisation-type BTB domain
    IPR003968 Potassium channel, voltage dependent, Kv
    IPR003974 Potassium channel, voltage dependent, Kv3
    IPR005405 Potassium channel, voltage dependent, Kv3.4
    IPR021645 Shal-type voltage-gated potassium channels, N-terminal
    IPR011333 SKP1/BTB/POZ domain superfamily
    IPR027359 Voltage-dependent channel domain superfamily
    IPR028325 Voltage-gated potassium channel
  • GlyGen
    Q8R1C0 2 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 14
    Genomic 2
    cDNA 11
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11574, MGD-MRK-11582, MGI:2139819
References
more
  • Summaries
    All 47
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:2312 Ghanshani S, et al., Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. Genomics. 1992 Feb;12(2):190-6
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory