Krt19 MGI Mouse Gene Detail - MGI:96693

Symbol

Krt19
Name

keratin 19
Synonyms

cytokeratin 19, cytokeratin-19, cytokeratin19, EndoC, K19, Krt-1.19, Krt1-19, MGC:25344

Feature Type

protein coding gene
IDs

MGI:96693
NCBI Gene: 16669
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr11:100031636-100036752 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 63.42 cM
Mapping Data

9 experiments

SNPs within 2kb

200 from dbSNP Build 142
Strain Annotations

18
PCR

2
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96693	protein coding gene	Chr11:100031636-100039491 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019143	protein coding gene	Chr11:102889238-102897097 (-)
A/J	MGP_AJ_G0019111	protein coding gene	Chr11:98546453-98554672 (-)
AKR/J	MGP_AKRJ_G0019080	protein coding gene	Chr11:101591190-101599049 (-)
BALB/cJ	MGP_BALBcJ_G0019085	protein coding gene	Chr11:99062960-99070790 (-)
C3H/HeJ	MGP_C3HHeJ_G0018894	protein coding gene	Chr11:101790503-101798358 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019534	protein coding gene	Chr11:106056636-106064493 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017161	protein coding gene	Chr11:96001166-96009090 (-)
CAST/EiJ	MGP_CASTEiJ_G0018448	protein coding gene	Chr11:102771023-102778653 (-)
CBA/J	MGP_CBAJ_G0018863	protein coding gene	Chr11:110492052-110499882 (-)
DBA/2J	MGP_DBA2J_G0018976	protein coding gene	Chr11:98121541-98129400 (-)
FVB/NJ	MGP_FVBNJ_G0018965	protein coding gene	Chr11:97622655-97631685 (-)
LP/J	MGP_LPJ_G0019044	protein coding gene	Chr11:103427705-103436059 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018996	protein coding gene	Chr11:110116327-110124169 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019572	protein coding gene	Chr11:101968696-101976526 (-)
PWK/PhJ	MGP_PWKPhJ_G0018211	protein coding gene	Chr11:99152740-99161063 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018003	protein coding gene	Chr11:101669886-101679171 (-)
WSB/EiJ	MGP_WSBEiJ_G0018497	protein coding gene	Chr11:101936445-101944277 (-)

Human Ortholog

KRT19, keratin 19

Vertebrate Orthologs

16

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KRT19, keratin 19
Synonyms

CK19, K19, K1CS
Links

HGNC:6436

NCBI Gene ID: 3880

neXtProt AC: NX_P08727

UniProt: P08727
Chr Location

17q21.2; chr17:41523617-41528308 (-) GRCh38

MGI Vertebrate Homology

Krt19 stringent orthology
1 human;1 mouse;1 rat;14 zebrafish
HCOP

vertebrate homology predictions: KRT19
Gene Tree

Krt19

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Phenotype Summary

9 phenotypes from 3 alleles in 4 genetic backgrounds
51 phenotypes from multigenic genotypes
2 images
116 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

4
Targeted

8
Genomic Mutations

2 involving Krt19
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-in allele are viable. Mice homozygous for a reporter allele show partial and strain-dependent preweaning lethality but no anatomical or behavioral defects. Mice that are either homozygous or heterozygous for a targeted insertion into intron 6 exhibit sperm tail defects.

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All GO Annotations

22
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1235
Tissues

157
cDNA Data

296
Literature Summary

153

Images

Tissue x Stage Matrix

Other Mouse Links

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA KRT24

Xenbase krt19

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All Sequences

37
RefSeq

4
UniProt

2
CCDS

CCDS25411.1

Ensembl

ENSMUSG00000020911 (Evidence)
NCBI Gene

16669

			Length	Strain/Species	Flank
genomic	16669	NCBI Gene Model \| MGI Sequence Detail	5117	C57BL/6J	± kb
transcript	NM_008471	RefSeq \| MGI Sequence Detail	1396	ZRU/MplStud
polypeptide	P19001	UniProt \| EBI \| MGI Sequence Detail	403	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009459 keratin, type I cytoskeletal 19

(term hierarchy)
InterPro Domains

IPR018039 Intermediate filament protein, conserved site

IPR039008 Intermediate filament, rod domain

IPR002957 Keratin, type I
GlyGen

P19001 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 317

Genomic 10

cDNA 296

Primer pair 11

Microarray probesets 3

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MGD-MRK-11633, MGD-MRK-11648, MGI:2144260

Summaries

All 298

Developmental Gene Expression 153

Gene Ontology 11

Phenotypes 116
Earliest

J:10112 Ichinose Y, et al., Molecular cloning and characterization of cDNA encoding mouse cytokeratin no. 19. Gene. 1989 Aug 15;80(2):315-23
Latest

J:353722 Xu J, et al., Keratin 19 (Krt19) is a novel marker gene for epicardial cells. Front Genet. 2024;15:1385867

TSS for Krt19:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110759	Chr11:100036792-100036804 (-)	-46 bp
Tssr110758	Chr11:100036767-100036772 (-)	-18 bp
Tssr110757	Chr11:100036744-100036761 (-)	-1 bp
Tssr110756	Chr11:100034531-100034568 (-)	2,202 bp
Tssr110755	Chr11:100034389-100034413 (-)	2,351 bp
Tssr110754	Chr11:100033012-100033034 (-)	3,729 bp
Tssr110753	Chr11:100032953-100032977 (-)	3,787 bp
Tssr110752	Chr11:100032653-100032683 (-)	4,084 bp
Tssr110751	Chr11:100032504-100032516 (-)	4,242 bp
Tssr110750	Chr11:100032454-100032472 (-)	4,289 bp
Tssr110749	Chr11:100032373-100032419 (-)	4,356 bp
Tssr110748	Chr11:100031837-100031984 (-)	4,841 bp
Tssr110747	Chr11:100031678-100031701 (-)	5,062 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24