Krt7 MGI Mouse Gene Detail - MGI:96704

Symbol

Krt7
Name

keratin 7
Synonyms

Cytokeratin 7, D15Wsu77e, K7, Krt2-7

Feature Type

protein coding gene
IDs

MGI:96704
NCBI Gene: 110310
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr15:101310284-101325687 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 56.88 cM
Mapping Data

5 experiments

SNPs within 2kb

422 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96704	protein coding gene	Chr15:101308924-101328194 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022371	protein coding gene	Chr15:103473009-103493839 (+)
A/J	MGP_AJ_G0022333	protein coding gene	Chr15:99378869-99398114 (+)
AKR/J	MGP_AKRJ_G0022309	protein coding gene	Chr15:102408051-102427333 (+)
BALB/cJ	MGP_BALBcJ_G0022337	protein coding gene	Chr15:99479084-99501811 (+)
C3H/HeJ	MGP_C3HHeJ_G0022107	protein coding gene	Chr15:102489854-102509987 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022785	protein coding gene	Chr15:107317273-107339006 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020310	protein coding gene	Chr15:95107936-95126700 (+)
CAST/EiJ	MGP_CASTEiJ_G0021632	protein coding gene	Chr15:103345917-103366602 (+)
CBA/J	MGP_CBAJ_G0022076	protein coding gene	Chr15:111045240-111067844 (+)
DBA/2J	MGP_DBA2J_G0022203	protein coding gene	Chr15:98708045-98727515 (+)
FVB/NJ	MGP_FVBNJ_G0022182	protein coding gene	Chr15:97760592-97781031 (+)
LP/J	MGP_LPJ_G0022274	protein coding gene	Chr15:103613764-103633016 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022203	protein coding gene	Chr15:114723134-114745571 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022799	protein coding gene	Chr15:102439229-102459860 (+)
PWK/PhJ	MGP_PWKPhJ_G0021371	protein coding gene	Chr15:98865544-98885117 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021203	protein coding gene	Chr15:102331336-102353838 (+)
WSB/EiJ	MGP_WSBEiJ_G0021682	protein coding gene	Chr15:103069847-103090758 (+)

Human Ortholog

KRT7, keratin 7

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KRT7, keratin 7
Synonyms

CK7, K2C7, K7, SCL
Links

HGNC:6445

NCBI Gene ID: 3855

neXtProt AC: NX_P08729

UniProt: P08729
Chr Location

12q13.13; chr12:52232520-52255853 (+) GRCh38

MGI Vertebrate Homology

Krt7 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: KRT7
Gene Tree

Krt7

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
1 images
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Radiation induced

2
Targeted

6
Genomic Mutations

4 involving Krt7
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele exhibit increased cell proliferation of urothelial cells without histological evidence of hyperplasia.

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1132
Tissues

199
cDNA Data

86
Literature Summary

50

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase krt7

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All Sequences

42
RefSeq

2
UniProt

2
CCDS

CCDS27851.1

Ensembl

ENSMUSG00000023039 (Evidence)
NCBI Gene

110310

			Length	Strain/Species	Flank
genomic	110310	NCBI Gene Model \| MGI Sequence Detail	15404	C57BL/6J	± kb
transcript	NM_033073	RefSeq \| MGI Sequence Detail	1602	ZRU/MplStud
polypeptide	Q9DCV7	UniProt \| EBI \| MGI Sequence Detail	457	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009485 keratin, type II cytoskeletal 7

(term hierarchy)
InterPro Domains

IPR018039 Intermediate filament protein, conserved site

IPR039008 Intermediate filament, rod domain

IPR003054 Keratin, type II

IPR032444 Keratin type II head
GlyGen

Q9DCV7 1 site

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All nucleic 97

Genomic 8

cDNA 86

Primer pair 2

Other 1

Microarray probesets 3

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MGD-MRK-11659, MGD-MRK-34004, MGI:106312

Summaries

All 119

Developmental Gene Expression 50

Diseases 1

Gene Ontology 5

Phenotypes 37
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:348279 Wrynn T, et al., DeltaNp63 regulates Sfrp1 expression to direct salivary gland branching morphogenesis. PLoS One. 2024;19(5):e0301082

TSS for Krt7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133289	Chr15:101308934-101308976 (+)	-1,329 bp
Tssr133290	Chr15:101309001-101309019 (+)	-1,274 bp
Tssr133291	Chr15:101310298-101310314 (+)	22 bp
Tssr133292	Chr15:101312988-101313031 (+)	2,726 bp
Tssr133293	Chr15:101317493-101317505 (+)	7,215 bp
Tssr133294	Chr15:101318386-101318399 (+)	8,109 bp
Tssr133295	Chr15:101325491-101325502 (+)	15,213 bp
Tssr133296	Chr15:101325570-101325589 (+)	15,296 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24