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Lamp2 Gene Detail
Summary
  • Symbol
    Lamp2
  • Name
    lysosomal-associated membrane protein 2
  • Synonyms
    CD107b, Lamp-2, Lamp-2a, Lamp-2b, Lamp-2c, Mac3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96748
    NCBI Gene: 16784
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:37490234-37545331 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 22.67 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1085 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96748
 protein coding gene ChrX:37488524-37545337 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035665
 protein coding gene ChrX:33360575-33418534 (-)
A/J MGP_AJ_G0035650
 protein coding gene ChrX:33421160-33484773 (-)
AKR/J MGP_AKRJ_G0035567
 protein coding gene ChrX:34183610-34236605 (-)
BALB/cJ MGP_BALBcJ_G0035634
 protein coding gene ChrX:33129769-33184120 (-)
C3H/HeJ MGP_C3HHeJ_G0035338
 protein coding gene ChrX:33734230-33788477 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036165
 protein coding gene ChrX:34106685-34165085 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033017
 protein coding gene ChrX:31841499-31890925 (-)
CAST/EiJ MGP_CASTEiJ_G0034629
 protein coding gene ChrX:21743818-21796847 (-)
CBA/J MGP_CBAJ_G0035312
 protein coding gene ChrX:34984450-35041137 (-)
DBA/2J MGP_DBA2J_G0035466
 protein coding gene ChrX:33262330-33318533 (-)
FVB/NJ MGP_FVBNJ_G0035415
 protein coding gene ChrX:33004479-33061728 (-)
LP/J MGP_LPJ_G0035554
 protein coding gene ChrX:33771177-33827254 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035453
 protein coding gene ChrX:35323231-35379515 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036181
 protein coding gene ChrX:33410790-33462665 (-)
PWK/PhJ MGP_PWKPhJ_G0034330
 protein coding gene ChrX:21311905-21365439 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034175
 protein coding gene ChrX:22260487-22321589 (-)
WSB/EiJ MGP_WSBEiJ_G0034775
 protein coding gene ChrX:33102160-33157062 (-)



Homology
more
  • Human Ortholog
    LAMP2, lysosomal associated membrane protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LAMP2, lysosomal associated membrane protein 2
  • Synonyms
    CD107b, DND, LAMP-2, LAMPB, LGP110, LGP-96
  • Links
    NCBI Gene ID: 3920
    neXtProt AC: NX_P13473
    UniProt: P13473

  • Chr Location
    Xq24; chrX:120426148-120469365 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Lamp2 mouse models; 2 with human LAMP2 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    63 phenotypes from 3 alleles in 4 genetic backgrounds
    14 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The majority of hemizygous or homozygous mutant mice die prematurely displaying cardiomyopathy and accumulation of autophagic vacuoles in several tissues including liver, pancreas, spleen, kidney and skeletal and cardiac muscle.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    65
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    789
  • Tissues
    45
  • cDNA Data
    24
  • Literature Summary
    53
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000016534 Ensembl Gene Model | MGI Sequence Detail 55098 C57BL/6J ±  kb
    transcript ENSMUST00000074913 Ensembl | MGI Sequence Detail 2184 Not Applicable  
    polypeptide ENSMUSP00000074448 Ensembl | MGI Sequence Detail 416 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000002061 lysosome-associated membrane glycoprotein 2
      (term hierarchy)
    • PDB
      5GV3
    • InterPro Domains
      IPR002000 Lysosome-associated membrane glycoprotein
      IPR048528 Lysosome-associated membrane glycoprotein 2-like, luminal domains
      IPR048524 Lysosome-associated membrane glycoprotein 2-like, transmembrane domain
      IPR018134 Lysosome-associated membrane glycoprotein, conserved site
    • GlyGen
      P17047 18 sites, 20 N-linked glycans (11 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 2
      cDNA 26
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-11741, MGD-MRK-11745
    References
    more
    • Summaries
      All 174
      Developmental Gene Expression 53
      Diseases 3
      Gene Ontology 31
      Phenotypes 44
    • Earliest
      J:10386 Cha Y, et al., The cDNA sequence of mouse LAMP-2. Evidence for two classes of lysosomal membrane glycoproteins. J Biol Chem. 1990 Mar 25;265(9):5008-13
    • Latest
      J:344234 Zou W, et al., Lysosomal dynamics regulate mammalian cortical neurogenesis. Dev Cell. 2024 Jan 8;59(1):64-78.e5
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory