Lcn2 MGI Mouse Gene Detail - MGI:96757

Symbol

Lcn2
Name

lipocalin 2
Synonyms

24p3, neu-related lipocalin, NGAL, NRL

Feature Type

protein coding gene
IDs

MGI:96757
NCBI Gene: 16819
Alliance

gene page
Transcription Start Sites

20 TSS

Sequence Map

Chr2:32274649-32277751 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 22.09 cM, cytoband A3
Mapping Data

5 experiments

SNPs within 2kb

158 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96757	protein coding gene	Chr2:32274645-32278264 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025605	protein coding gene	Chr2:30834645-30838264 (-)
A/J	MGP_AJ_G0025582	protein coding gene	Chr2:29528910-29532536 (-)
AKR/J	MGP_AKRJ_G0025552	protein coding gene	Chr2:30584916-30588535 (-)
BALB/cJ	MGP_BALBcJ_G0025579	protein coding gene	Chr2:29654709-29658328 (-)
C3H/HeJ	MGP_C3HHeJ_G0025339	protein coding gene	Chr2:30476303-30479922 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026023	protein coding gene	Chr2:31776703-31780907 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023432	protein coding gene	Chr2:28255098-28258824 (-)
CAST/EiJ	MGP_CASTEiJ_G0024801	protein coding gene	Chr2:30412247-30415875 (-)
CBA/J	MGP_CBAJ_G0025317	protein coding gene	Chr2:32973173-32976792 (-)
DBA/2J	MGP_DBA2J_G0025450	protein coding gene	Chr2:29297847-29301466 (-)
FVB/NJ	MGP_FVBNJ_G0025412	protein coding gene	Chr2:29174219-29177838 (-)
LP/J	MGP_LPJ_G0025536	protein coding gene	Chr2:30712616-30716235 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025443	protein coding gene	Chr2:32633991-32637617 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026081	protein coding gene	Chr2:30466228-30470913 (-)
PWK/PhJ	MGP_PWKPhJ_G0024549	protein coding gene	Chr2:29201079-29204811 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024349	protein coding gene	Chr2:30623027-30628233 (-)
WSB/EiJ	MGP_WSBEiJ_G0024870	protein coding gene	Chr2:30639062-30642681 (-)

Human Ortholog

LCN2, lipocalin 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LCN2, lipocalin 2
Synonyms

24p3, MSFI, NGAL, p25
Links

HGNC:6526

NCBI Gene ID: 3934

neXtProt AC: NX_P80188

UniProt: P80188
Chr Location

9q34.11; chr9:128149071-128153453 (+) GRCh38

MGI Vertebrate Homology

Lcn2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: LCN2
Gene Tree

Lcn2

Diseases

1 with human LCN2 associations

				Human Disease	Mouse Models
				urinary tract infection IDs urinary tract infection DOID:0080784 ICD10CM:N39.0 MESH:D014552

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

53 phenotypes from 4 alleles in 7 genetic backgrounds
176 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

4
Targeted

14
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutants are more susceptible to infection with bacteria that utilize enterochelin-type siderophores to acquire iron and impaired thermogenesis. Mice homozygous for another knock-out allele exhibit apoptotic defects in hematopoietic cells.

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All GO Annotations

44
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

797
Tissues

32
cDNA Data

545
Literature Summary

20

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

42
RefSeq

2
UniProt

2
CCDS

CCDS15913.1

Ensembl

ENSMUSG00000026822 (Evidence)
NCBI Gene

16819

			Length	Strain/Species	Flank
genomic	16819	NCBI Gene Model \| MGI Sequence Detail	3103	C57BL/6J	± kb
transcript	NM_008491	RefSeq \| MGI Sequence Detail	853	Swiss
polypeptide	P11672	UniProt \| EBI \| MGI Sequence Detail	200	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009725 neutrophil gelatinase-associated lipocalin

(term hierarchy)
PDB

3S26, 3U9P
InterPro Domains

IPR012674 Calycin

IPR002345 Lipocalin

IPR000566 Lipocalin/cytosolic fatty-acid binding domain

IPR022272 Lipocalin family conserved site

IPR003087 Neutrophil gelatinase-associated lipocalin/epididymal-specific lipocalin-12
GlyGen

P11672 2 sites

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All nucleic 550

cDNA 545

Primer pair 3

Other 2

Microarray probesets 3

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MGD-MRK-11759, MGI:2139327

Summaries

All 276

Developmental Gene Expression 20

Gene Ontology 13

Phenotypes 176
Earliest

J:20468 Hraba-Renevey S, et al., SV40-induced expression of mouse gene 24p3 involves a post-transcriptional mechanism. Oncogene. 1989 May;4(5):601-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lcn2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr23515	Chr2:32278234-32278266 (-)	-499 bp
Tssr23514	Chr2:32278103-32278108 (-)	-355 bp
Tssr23513	Chr2:32277772-32277790 (-)	-30 bp
Tssr23512	Chr2:32277145-32277175 (-)	591 bp
Tssr23511	Chr2:32277093-32277117 (-)	646 bp
Tssr23510	Chr2:32277067-32277077 (-)	679 bp
Tssr23509	Chr2:32276096-32276105 (-)	1,650 bp
Tssr462	Chr2:32276083-32276088 (-)	1,665 bp
Tssr23508	Chr2:32276068-32276080 (-)	1,677 bp
Tssr23507	Chr2:32276032-32276054 (-)	1,708 bp
Tssr461	Chr2:32276019-32276026 (-)	1,728 bp
Tssr23506	Chr2:32275993-32276013 (-)	1,748 bp
Tssr23505	Chr2:32275786-32275842 (-)	1,937 bp
Tssr23504	Chr2:32275757-32275771 (-)	1,987 bp
Tssr23503	Chr2:32275528-32275533 (-)	2,220 bp
Tssr23502	Chr2:32275510-32275523 (-)	2,234 bp
Tssr23501	Chr2:32275476-32275505 (-)	2,260 bp
Tssr23500	Chr2:32275453-32275475 (-)	2,287 bp
Tssr23499	Chr2:32274761-32274913 (-)	2,914 bp
Tssr23498	Chr2:32274708-32274723 (-)	3,035 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24