Ldha MGI Mouse Gene Detail - MGI:96759 - lactate dehydrogenase A

Symbol

Ldha
Name

lactate dehydrogenase A
Synonyms

l7R2, lactate dehydrogenase-A, Ldh-1, Ldh1, LDH-A

Feature Type

protein coding gene
IDs

MGI:96759
NCBI Gene: 16828
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr7:46491698-46505051 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 30.60 cM
Mapping Data

19 experiments

SNPs within 2kb

498 from dbSNP Build 142
Strain Annotations

18
PCR

2
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96759	protein coding gene	Chr7:46490899-46505051 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032274	protein coding gene	Chr7:47243887-47259027 (+)
A/J	MGP_AJ_G0032253	protein coding gene	Chr7:46266103-46280557 (+)
AKR/J	MGP_AKRJ_G0032189	protein coding gene	Chr7:47577244-47591394 (+)
BALB/cJ	MGP_BALBcJ_G0032265	protein coding gene	Chr7:46268264-46282359 (+)
C3H/HeJ	MGP_C3HHeJ_G0031978	protein coding gene	Chr7:48050749-48065573 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032755	protein coding gene	Chr7:49511849-49525997 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029771	protein coding gene	Chr7:48804330-48818344 (+)
CAST/EiJ	MGP_CASTEiJ_G0031306	protein coding gene	Chr7:39521211-39536971 (+)
CBA/J	MGP_CBAJ_G0031943	protein coding gene	Chr7:51176594-51191986 (+)
DBA/2J	MGP_DBA2J_G0032100	protein coding gene	Chr7:45943328-45957503 (+)
FVB/NJ	MGP_FVBNJ_G0032054	protein coding gene	Chr7:45751967-45766975 (+)
LP/J	MGP_LPJ_G0032181	protein coding gene	Chr7:47941727-47955869 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032091	protein coding gene	Chr7:49796292-49810721 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032772	protein coding gene	Chr7:46779344-46793490 (+)
PWK/PhJ	MGP_PWKPhJ_G0031029	protein coding gene	Chr7:39324094-39339486 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030869	protein coding gene	Chr7:34802698-34816230 (+)
WSB/EiJ	MGP_WSBEiJ_G0031426	protein coding gene	Chr7:47294920-47315740 (+)

Human Ortholog

LDHA, lactate dehydrogenase A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LDHA, lactate dehydrogenase A
Synonyms

GSD11, HEL-S-133P, LDHM, PIG19
Links

HGNC:6535

NCBI Gene ID: 3939

neXtProt AC: NX_P00338

UniProt: P00338
Chr Location

11p15.1; chr11:18394560-18408425 (+) GRCh38

MGI Vertebrate Homology

Ldha stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LDHA
Protein SuperFamily

Lac_mal_DH
Gene Tree

Ldha

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Phenotype Summary

30 phenotypes from 13 alleles in 13 genetic backgrounds
1 phenotype from multigenic genotypes
63 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

41
Chemically induced (ENU)

7
Chemically induced (other)

2
Endonuclease-mediated

5
Gene trapped

19
Radiation induced

3
Targeted

4
Transgenic

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for one chemically induced mutation exhibit severe hemolytic anemia with pronounced reticulocytosis and hyperbilirubinemia. Another mutation results in prenatal lethality in homozygotes.

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All GO Annotations

31
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

859
Tissues

130
cDNA Data

1177
Literature Summary

43

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA LDHA

Xenbase ldha

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All Sequences

169
RefSeq

7
UniProt

19
CCDS

CCDS21289.1, CCDS52255.1

Ensembl

ENSMUSG00000063229 (Evidence)
NCBI Gene

16828

			Length	Strain/Species	Flank
genomic	16828	NCBI Gene Model \| MGI Sequence Detail	13354	C57BL/6J	± kb
transcript	NM_001136069	RefSeq \| MGI Sequence Detail	1854	ZRU/MplStud
polypeptide	P06151	UniProt \| EBI \| MGI Sequence Detail	332	Not Applicable

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UniProt

19 Sequences
Protein Ontology

PR:000009739 L-lactate dehydrogenase A chain

(term hierarchy)
EC

1.1.1.27
InterPro Domains

IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

IPR022383 Lactate/malate dehydrogenase, C-terminal

IPR001236 Lactate/malate dehydrogenase, N-terminal

IPR011304 L-lactate dehydrogenase

IPR018177 L-lactate dehydrogenase, active site

IPR001557 L-lactate/malate dehydrogenase

IPR036291 NAD(P)-binding domain superfamily
GlyGen

P06151 1 site, 1 O-linked glycan (1 site)

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All nucleic 1198

Genomic 12

cDNA 1178

Primer pair 7

Other 1

Microarray probesets 3

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MGD-MRK-11762, MGD-MRK-11768, MGI:1890511

Summaries

All 171

Developmental Gene Expression 43

Gene Ontology 13

Phenotypes 63
Earliest

J:5105 Ruddle FH, et al., Allelically-determined isozyme polymorphisms in laboratory populations of mice. Ann N Y Acad Sci. 1968 Jun 14;151(1):531-9
Latest

J:355682 Li H, et al., AARS1 and AARS2 sense L-lactate to regulate cGAS as global lysine lactyltransferases. Nature. 2024 Sep 25;

TSS for Ldha:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr66714	Chr7:46490941-46490962 (+)	-746 bp
Tssr66715	Chr7:46495256-46495272 (+)	3,566 bp
Tssr66716	Chr7:46495639-46495661 (+)	3,952 bp
Tssr66717	Chr7:46495708-46495727 (+)	4,020 bp
Tssr66718	Chr7:46496526-46496542 (+)	4,836 bp
Tssr66719	Chr7:46496552-46496574 (+)	4,865 bp
Tssr66720	Chr7:46496579-46496592 (+)	4,888 bp
Tssr66721	Chr7:46496624-46496631 (+)	4,930 bp
Tssr66722	Chr7:46496953-46496957 (+)	5,257 bp
Tssr66723	Chr7:46499625-46499639 (+)	7,934 bp
Tssr66724	Chr7:46499641-46499654 (+)	7,950 bp
Tssr66725	Chr7:46499658-46499677 (+)	7,970 bp
Tssr66726	Chr7:46502591-46502595 (+)	10,895 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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