Ldhb MGI Mouse Gene Detail - MGI:96763 - lactate dehydrogenase B

Symbol

Ldhb
Name

lactate dehydrogenase B
Synonyms

H-Ldh, lactate dehydrogenase-B, Ldh-2

Feature Type

protein coding gene
IDs

MGI:96763
NCBI Gene: 16832
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr6:142435975-142453683 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 74.17 cM
Mapping Data

4 experiments

SNPs within 2kb

728 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96763	protein coding gene	Chr6:142435975-142453683 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031466	protein coding gene	Chr6:147281757-147299438 (-)
A/J	MGP_AJ_G0031441	protein coding gene	Chr6:141495527-141513292 (-)
AKR/J	MGP_AKRJ_G0031369	protein coding gene	Chr6:145711053-145728869 (-)
BALB/cJ	MGP_BALBcJ_G0031448	protein coding gene	Chr6:141268775-141287400 (-)
C3H/HeJ	MGP_C3HHeJ_G0031170	protein coding gene	Chr6:145747553-145768246 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031910	protein coding gene	Chr6:151328683-151347760 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029034	protein coding gene	Chr6:140327479-140345514 (-)
CAST/EiJ	MGP_CASTEiJ_G0030538	protein coding gene	Chr6:145313856-145331560 (-)
CBA/J	MGP_CBAJ_G0031130	protein coding gene	Chr6:157072992-157093846 (-)
DBA/2J	MGP_DBA2J_G0031287	protein coding gene	Chr6:140310546-140328692 (-)
FVB/NJ	MGP_FVBNJ_G0031238	protein coding gene	Chr6:139074696-139093603 (-)
LP/J	MGP_LPJ_G0031371	protein coding gene	Chr6:147418191-147441161 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031278	protein coding gene	Chr6:160955242-160975491 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031942	protein coding gene	Chr6:145537325-145555081 (-)
PWK/PhJ	MGP_PWKPhJ_G0030265	protein coding gene	Chr6:138807659-138825844 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030089	protein coding gene	Chr6:143726860-143744632 (-)
WSB/EiJ	MGP_WSBEiJ_G0030631	protein coding gene	Chr6:146153646-146173622 (-)

Human Ortholog

LDHB, lactate dehydrogenase B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LDHB, lactate dehydrogenase B
Synonyms

HEL-S-281, LDH-B, LDHBD, LDH-H, TRG-5
Links

HGNC:6541

NCBI Gene ID: 3945

neXtProt AC: NX_P07195

UniProt: P07195
Chr Location

12p12.1; chr12:21635342-21757857 (-) GRCh38

MGI Vertebrate Homology

Ldhb stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: LDHB
Protein SuperFamily

Lac_mal_DH
Gene Tree

Ldhb

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

5
Gene trapped

1
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available

Electrophoretic variants of LDHB are determined by: the a allele with fast anodal mobility in all inbred strains tested; and the b allele with slower mobility in Peru-Coppock stock. Three additional variants are known in wild M. spretus from southern France and Spain. Alleles are codominant.

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All GO Annotations

25
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1052
Tissues

118
cDNA Data

17
Literature Summary

18

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ldhb

ZFIN ldhba, ldhbb

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All Sequences

57
RefSeq

6
UniProt

6
CCDS

CCDS20684.1

Ensembl

ENSMUSG00000030246 (Evidence)
NCBI Gene

16832

			Length	Strain/Species	Flank
genomic	16832	NCBI Gene Model \| MGI Sequence Detail	17709	C57BL/6J	± kb
transcript	NM_001316322	RefSeq \| MGI Sequence Detail	1338	ZRU/MplStud
polypeptide	P16125	UniProt \| EBI \| MGI Sequence Detail	334	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000009742 L-lactate dehydrogenase B chain

(term hierarchy)
EC

1.1.1.27
InterPro Domains

IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

IPR022383 Lactate/malate dehydrogenase, C-terminal

IPR001236 Lactate/malate dehydrogenase, N-terminal

IPR011304 L-lactate dehydrogenase

IPR018177 L-lactate dehydrogenase, active site

IPR001557 L-lactate/malate dehydrogenase

IPR036291 NAD(P)-binding domain superfamily
GlyGen

P16125 1 site, 1 O-linked glycan (1 site)

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All nucleic 22

cDNA 17

Primer pair 4

Other 1

Microarray probesets 6

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MGD-MRK-11766, MGD-MRK-11772, MGI:2141472

Summaries

All 77

Developmental Gene Expression 18

Gene Ontology 10

Phenotypes 16
Earliest

J:5101 Epstein CJ, Mammalian oocytes: X chromosome activity. Science. 1969 Mar 7;163(871):1078-9
Latest

J:350558 Spate E, et al., Downregulated expression of lactate dehydrogenase in adult oligodendrocytes and its implication for the transfer of glycolysis products to axons. Glia. 2024 Aug;72(8):1374-1391

TSS for Ldhb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr63957	Chr6:142453636-142453688 (-)	21 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24